[1]陈茉 徐书杭 刘超.良性甲状腺结节的热消融治疗进展[J].国际内分泌代谢杂志,2019,39(04):248-252.[doi:10.3760/cma.j.issn.1673-4157.2019.04.008]
 Chen Mo,Xu Shuhang,Liu Chao.Advancement of thermal ablation on benign thyroid nodules[J].International Journal of Endocrinology and Metabolism,2019,39(04):248-252.[doi:10.3760/cma.j.issn.1673-4157.2019.04.008]
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良性甲状腺结节的热消融治疗进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年04期
页码:
248-252
栏目:
综述
出版日期:
2019-07-20

文章信息/Info

Title:
Advancement of thermal ablation on benign thyroid nodules
作者:
陈茉 徐书杭 刘超
南京中医药大学附属中西医结合医院(江苏省中医药研究院)内分泌科 210028
Author(s):
Chen Mo Xu Shuhang Liu Chao
Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China
关键词:
甲状腺结节 热消融 射频消融 微波消融
Keywords:
Thyroid nodule Thermal ablation Radiofrequency ablation Microwave ablation
DOI:
10.3760/cma.j.issn.1673-4157.2019.04.008
摘要:
热消融是近年来发展起来的一项新技术,主要包括激光消融、射频消融、微波消融和高强度聚焦超声。目前,仍缺乏国际公认的良性甲状腺结节热消融指征。但综合国内、外相关指南及专家共识,在结合患者意愿的基础上,热消融可用于有临床症状、有自主功能或术后复发的良性甲状腺结节。现有研究表明,热消融对于良性甲状腺结节具有良好的效果和安全性,术后1年结节体积可缩小50%~80%,不良反应发生率较低,且不同消融方法之间差别有限。总之,热消融可能为良性甲状腺结节治疗提供新的选择。
Abstract:
Thermal ablation is a new technology developed in recent years, including laser ablation, radiofrequency ablation, microwave ablation and high intensity focused ultrasound. At present, there is a lack of internationally recognized indications for thermal ablation of benign thyroid nodules. However, based on the relevant guidelines and consensus statement, thermal ablation can be used for benign thyroid nodules with clinical symptoms, autonomic functional nodules or recurrent nodules after operation, considering the patients's will. Many clinical studies have shown that thermal ablation has a favorable effect and safety for benign thyroid nodules. The nodule volume can be reduced by 50% to 80% at 1 year follow-up with low incidence of side effects. Besides, the differences between various types of ablation methods are limited. Therefore, thermal ablation may become a new choice for treatment of benign thyroid nodules.

参考文献/References:

[1] Nixon IJ,Angelos P,Shaha AR,et al. Image-guided chemical and thermal ablations for thyroid disease: review of efficacy and complications[J].Head Neck,2018,40(9):2103-2115. DOI:10.1002/hed.25181.
[2] Gharib H,Hegedüs L,Pacella CM,et al.Clinical review: nonsurgical, image-guided, minimally invasive therapy for thyroid nodules[J].J Clin Endocrinol Metab,2013,98(10):3949-3957.DOI:10.1210/jc.2013-1806.
[3] Yang YL,Chen CZ,Zhang XH.Microwave ablation of benign thyroid nodules[J].Future Oncol,2014,10(6):1007-1014.DOI:10.2217/fon.13.260.
[4] Cheng Z,Che Y,Yu S,et al.US-guided percutaneous radiofrequency versus microwave ablation for benign thyroid nodules: a prospective multicenter study[J].Sci Rep,2017,7(1):9554.DOI:10.1038/s41598-017-09930-7.
[5] Lang BH,Wu ALH.The efficacy and safety of high-intensity focused ultrasound ablation of benign thyroid nodules[J].Ultrasonography,2018,37(2):89-97. DOI:10.14366/usg.17057.
[6] Na DG,Lee JH,Jung SL,et al.Radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers: consensus statement and recommendations[J].Korean J Radiol,2012,13(2):117-125. DOI:10.3348/kjr.2012.13.2.117.
[7] Garberoglio R,Aliberti C,Appetecchia M,et al.Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement[J].J Ultrasound,2015,18(4):423-430.DOI:10.1007/s40477-015-0169-y.
[8] Kim JH,Baek JH,Lim HK,et al.2017 Thyroid radiofrequency ablation guideline: Korean Society of Thyroid Radiology[J].Korean J Radiol,2018,19(4):632-655.DOI:10.3348/kjr.2018.19.4.632.
[9] Pacella CM,Bizzarri G,Guglielmi R,et al.Thyroid tissue: US-guided percutaneous interstitial laser ablation-a feasibility study[J].Radiology,2000,217(3):673-677.DOI:10.1148/radiology.217.3.r00dc09673.
[10] Døssing H,Bennedbaek FN,Karstrup S,et al.Benign solitary solid cold thyroid nodules: US-guided interstitial laser photocoagulation--initial experience[J].Radiology,2002,225(1):53-57.DOI:10.1148/ radiol.2251011042.
[11] Spiezia S,Vitale G,Di Somma C,et al.Ultrasound-guided laser thermal ablation in the treatment of autonomous hyperfunctioning thyroid nodules and compressive nontoxic nodular goiter[J].Thyroid,2003,13(10):941-947.DOI: 10.1089/105072503322511346.
[12] Gambelunghe G,Stefanetti E,Colella R,et al.A single session of laser ablation for toxic thyroid nodules: three-year follow-upresults[J].Int J Hyperthermia,2018,34(5):631-635.DOI:10.1080/02656736.2018.1437931.
[13] Lim HK,Lee JH,Ha EJ,et al.Radiofrequency ablation of benign non-functioning thyroid nodules: 4-year follow-up results for 111 patients[J].Eur Radiol,2013,23(4):1044-1049.DOI:10.1007/s00330-012-2671-3.
[14] Dobnig H,Amrein K.Monopolar radiofrequency ablation of thyroid nodules: a prospective Austrian single-center study[J].Thyroid,2018,28(4):472-480.DOI:10.1089/thy.2017.0547.
[15] Hamidi O,Callstrom MR, Lee RA,et al.Outcomes of radiofrequency ablation therapy for large benign thyroid nodules: a Mayo clinic case series[J].Mayo Clin Proc,2018,93(8):1018-1025.DOI:10.1016/j.mayocp.2017.12.011.
[16] Pacella CM,Mauri G,Cesareo R,et al.A comparison of laser with radiofrequency ablation for the treatment of benign thyroid nodules: a propensity score matching analysis[J].Int J Hyperthermia,2017,33(8):911-919. DOI:10.1080/02656736.2017.1332395.
[17] Sung JY,Baek JH,Jung SL,et al.Radiofrequency ablation for autonomously functioning thyroid nodules: a multicenter study[J].Thyroid,2015,25(1):112-117. DOI:10.1089/thy.2014.0100.
[18] Wei Y,Qian L,Liu JB,et al.Sonographic measurement of thyroid nodule changes after microwave ablation: relationship between multiple parameters[J].Int J Hyperthermia,2018,34(5):660-668.DOI:10.1080/02656736.2017.1418537.
[19] Wu W,Gong X,Zhou Q,et al.US-guided percutaneous microwave ablation for the treatment of benign thyroid nodules[J].Endocr J,2017,64(11):1079-1085.DOI:10.1507/endocrj.EJ17-0152.
[20] Liu YJ,Qian LX,Liu D,et al.Ultrasound-guided microwave ablation in the treatment of benign thyroid nodules in 435 patients[J].Exp Biol Med(Maywood),2017,242(15):1515-1523.DOI:10.1177/1535370217727477.
[21] Yue WW,Wang SR,Lu F,et al.Radiofrequency ablation vs. microwave ablation for patients with benign thyroid nodules: a propensity score matching study[J].Endocrine,2017,55(2):485-495.DOI:10.1007/s12020-016-1173-5.
[22] Trimboli P,Bini F,Marinozzi F,et al.High-intensity focused ultrasound(HIFU)therapy for benign thyroid nodules without anesthesia or sedation[J].Endocrine,2018,61(2):210-215.DOI:10.1007/s12020-018-1560-1.
[23] Korkusuz Y,Gröner D,Raczynski N,et al.Thermal ablation of thyroid nodules: are radiofrequency ablation, microwave ablation and high intensity focused ultrasound equally safe and effective methods?[J].Eur Radiol,2018,28(3):929-935.DOI:10.1007/s00330-017-5039-x.
[24] Giovanella L,Piccardo A,Pezzoli C,et al.Comparison of high intensity focused ultrasound and radioiodine for treating toxicthyroid nodules[J].Clin Endocrinol(Oxf),2018,[Epub ahead of print].DOI:10.1111/cen.13738.
[25] Baek JH,Lee JH,Sung JY,et al.Complications encountered in the treatment of benign thyroid nodules with US-guided radiofrequency ablation: a multicenter study[J].Radiology,2012,262(1):335-342.DOI:10.1148/radiol.11110416.
[26] Cesareo R,Pasqualini V,Simeoni C,et al.Prospective study of effectiveness of ultrasound-guided radiofrequency ablation versus control group in patients affected by benign thyroid nodules[J].J Clin Endocrinol Metab,2015,100(2):460-466.DOI:10.1210/jc.2014-2186.
[27] Bernardi S,Lanzilotti V,Papa G,et al.Full-thickness skin burn caused by radiofrequency ablation of a benign thyroid nodule[J].Thyroid,2016,26(1):183-184.DOI:10.1089/thy.2015.0453.

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备注/Memo

备注/Memo:
通信作者:徐书杭,Email:shuhangxu@163.com; 刘超,Email:liuchao@nfmcn.com
Corresponding author: Xu Shuhang, Email:shuhangxu@163.com; Liu Chao, Email: liuchao@nfmcn.com
基金项目:第二批江苏省中医药领军人才项目(SLJ0209); 江苏省医院协会医院管理创新研究课题(JSYGY-1-2018-301); 2018年江苏省研究生科研与实践创新计划面上项目(SJCX18_0470)
Fund program:The Second Batch of Leading Talent of Traditional Chinese Medicine in Jiangsu Province(SLJ0209); Innovation Project on Hospital Management of Jiangsu Provice Hospital Association(JSYGY-1-2018-301); Surface Project on Research and Practice Innovation for Graduate Students in Jiangsu Province(SJCX18_0470)
更新日期/Last Update: 2019-11-29