[1]林楚曼 林伟浩 周蕊 杨力.GLP-1缓解非酒精性脂肪性肝病相关信号通路的研究进展[J].国际内分泌代谢杂志,2018,38(03):179-182.[doi:10.3760/cma.j.issn.1673-4157.2018.03.009]
 Lin Chuman*,Lin Weihao,Zhou Rui,et al.The research progresses on GLP-1 related signal pathways in alleviating non-alcoholic fatty liver disease[J].International Journal of Endocrinology and Metabolism,2018,38(03):179-182.[doi:10.3760/cma.j.issn.1673-4157.2018.03.009]
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GLP-1缓解非酒精性脂肪性肝病相关信号通路的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年03期
页码:
179-182
栏目:
综述
出版日期:
2018-05-20

文章信息/Info

Title:
The research progresses on GLP-1 related signal pathways in alleviating non-alcoholic fatty liver disease
作者:
林楚曼 林伟浩 周蕊 杨力
510515 广州,南方医科大学第二临床医学院(林楚曼、林伟浩),基础医学院病理学系(周蕊); 510282 广州,南方医科大学珠江医院内分泌代谢科(杨力)
Author(s):
Lin Chuman* Lin Weihao Zhou Rui Yang Li.*
Second College of Clinical Medicine, Southern Medical University, Guangzhou 510515, China
关键词:
胰高血糖素样肽-1 非酒精性脂肪性肝病 信号通路
Keywords:
Glucagon-like peptide 1 Non-alcoholic fatty liver disease Signaling pathway
DOI:
10.3760/cma.j.issn.1673-4157.2018.03.009
摘要:
既往研究表明,胰高血糖素样肽-1(GLP-1)可改善肝脏脂肪变性,特别是在2型糖尿病患者中。研究GLP-1是否作用于肝细胞并影响非酒精性脂肪性肝病(NAFLD)的进展已成为防治NAFLD的研究热点。近年的研究发现,人肝细胞上有GLP-1受体(GLP-1R)的表达,提示GLP-1可直接作用于GLP-1R,并通过cAMP-蛋白激酶A-AMP活化蛋白激酶/沉默信息调节因子1、胰岛素受体底物1-磷酸肌醇依赖性酶1-蛋白激酶C/蛋白激酶B、Janus激酶-信号转导与转录激活因子、内质网转膜蛋白激酶1α-c-Jun氨基末端激酶等信号通路调节脂代谢相关基因的表达,改善肝脏脂肪代谢。
Abstract:
Previous studies have shown that glucagon-like peptide-1(GLP-1)can improve hepatic steatosis, especially in patients with type 2 diabetes. Therefore, the study of whether GLP-1 acts on hepatocytes and affects the progress of non-alcoholic fatty liver disease(NAFLD)has become a hotspot in the prevention and treatment of NAFLD. Recent studies have shown that GLP-1 receptor(GLP-1R)was expressed on human hepatocytes, suggesting that GLP-1 could act directly on GLP-1R. Besides, GLP-1 could regulate lipid metabolism-related genes via cAMP-protein kinase A-adenosine 5'-monophosphate -activated protein kinase/Sirtuin 1, insulin receptor substrate 1-phosphoinositide-dependent protein kinase-1-protein kinase C/protein kinase B, Janus kinase-signal transduction and activator of transcription, inositol-requiring enzyme 1-c-Jun N-terminal kinase signal pathway to improve lipid metabolism of the liver.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81270966); 广东省自然科学基金(2014A030310472); 南方医科大学2017年校级大学生创新训练计划项目(201712121342)
通信作者:杨力,Email: yangli19762009@163.com
更新日期/Last Update: 2018-03-30