[1]李静,李曙光,乐岭.二甲双胍抑制分化型甲状腺癌的作用及机制[J].国际内分泌代谢杂志,2021,41(01):28-32.[doi:10.3760/cma.j.cn121383-20200514-05032]
　Li Jing,Li Shuguang,Yue Ling..Effects and mechanisms of metformin on differentiated thyroid cancer[J].International Journal of Endocrinology and Metabolism,2021,41(01):28-32.[doi:10.3760/cma.j.cn121383-20200514-05032]
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二甲双胍抑制分化型甲状腺癌的作用及机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年01期
页码:
28-32
栏目:
甲状腺疾病专题
出版日期:
2021-01-20

文章信息/Info

Title:
Effects and mechanisms of metformin on differentiated thyroid cancer
作者:
李静1; 2; 李曙光1; 乐岭1; 2
1中国人民解放军中部战区总医院内分泌科,武汉 430070; 2南方医科大学第一临床医学院,广州 510515
Author(s):
Li Jing1; 2;  Li Shuguang1;  Yue Ling1; 2.
1Department of Endocrinology, Central Theater Command General Hospital of the Chinese People's Liberation Army, Wuhan 430070, China; 2the First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China
关键词:
二甲双胍;  分化型甲状腺癌;  腺苷酸活化蛋白激酶
Keywords:
Metformin;  Differentiated thyroid cancer;  AMP-activated protein kinase
DOI:
10.3760/cma.j.cn121383-20200514-05032
摘要:
二甲双胍是治疗糖尿病的一线药物,晚近其抗肿瘤效应受到广泛关注。研究发现,服用二甲双胍的2型糖尿病患者分化型甲状腺癌(differentiated thyroid cancer,DTC)的风险降低,其机制可能与一方面通过改善胰岛素抵抗、下调促甲状腺激素(thyroid-stimulating hormone,TSH)和激活腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)通路抑制DTC细胞增殖,一方面通过促进自噬与内质网应激诱导DTC细胞凋亡以及通过信号转导和转录活化因子3(signal transducer and activator of transcription 3,STAT3)/细胞外信号调节激酶(extracellular signal-regulated kinase,ERK)通路、抑制炎性反应、抑制肿瘤细胞能量代谢、抑制DTC细胞侵袭等有关。二甲双胍有望成为DTC治疗新的辅助治疗方法。
Abstract:
Metformin is a first-line drug in the treatment of diabetes. Recently, its anti-tumor effect has attracted wide attention. Some studies have found that the risk of differentiated thyroid cancer(DTC)is reduced in patients with type 2 diabetes taking metformin. The mechanisms may be associating with improving insulin resistance, regulating thyroid-stimulating hormone(TSH)and activating the AMP-activated protein kinase(AMPK)pathway to inhibit the proliferation of DTC cells; promoting autophagy and endoplasmic reticulum stress to induce apoptosis of DTC cells; inhibiting signal transduction and activator of transcription 3(STAT3)/extracellular signal-regulated kinase(ERK)pathway and inflammation, inhibiting energy metabolism of tumor cells to suppress DTC cell invasion. Metformin is expected to be a neoadjuvant therapy for DTC.

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备注/Memo

备注/Memo:
通信作者:乐岭,Email: yuelingwh@163.com
更新日期/Last Update: 2021-01-20