[1]何沙沙,张洁,管璐璐,等.食源性晚期糖基化终末产物对肠道菌群及代谢相关疾病的影响研究进展[J].国际内分泌代谢杂志,2023,43(01):10-13.[doi:10.3760/cma.j.cn121383-20220131-01060]
　He Shasha,Zhang Jie,Guan Lulu,et al.Research progress on the effects of dietary advanced glycation end products on intestinal flora and metabolic disease[J].International Journal of Endocrinology and Metabolism,2023,43(01):10-13.[doi:10.3760/cma.j.cn121383-20220131-01060]
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食源性晚期糖基化终末产物对肠道菌群及代谢相关疾病的影响研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年01期
页码:
10-13
栏目:
肠道菌群与代谢性疾病专题
出版日期:
2023-01-20

文章信息/Info

Title:
Research progress on the effects of dietary advanced glycation end products on intestinal flora and metabolic disease
作者:
何沙沙; 张洁; 管璐璐; 徐积兄
南昌大学第一附属医院内分泌代谢科,江西省内分泌代谢病临床医学研究中心,国家代谢性疾病临床医学研究中心江西分中心,南昌 330006
Author(s):
He Shasha;  Zhang Jie;  Guan Lulu;  Xu Jixiong.
Department of Endocrine and Metabolism, First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang 330006, China
关键词:
晚期糖基化终末产物;  美拉德反应;  肠道菌群;  代谢性疾病
Keywords:
Advanced glycation end products;  Maillard reaction;  Gut microbiota;  Metabolic disease
DOI:
10.3760/cma.j.cn121383-20220131-01060
摘要:
食源性晚期糖基化终末产物(AGEs)是在食品加工过程中生成的,长时间、干热及高温会加速AGEs的形成。食源性AGEs的过量摄入被认为与许多疾病有关。由于食源性AGEs大都为高分子物质,在肠内不能被完全吸收或排泄,而在结肠内被细菌代谢。目前食源性AGEs对肠道菌群的影响结果并不一致,这可能是由于食物在加热过程中形成了其他化合物。本综述总结了关于AGEs的来源、吸收及其与代谢相关疾病的联系,并汇总了目前开展的人体及动物研究对肠道微生物组成及其代谢产物的影响。
Abstract:
Dietary advanced glycation end products(AGEs)are produced during food processing, and long time, dry heat and high temperature will accelerate the formation of AGEs. Excessive intake of dietary AGEs is thought to be associated with many diseases. As most of the dietary AGEs are high molecular substances, they can not be completely absorbed or excreted in the intestine, but are metabolized by bacteria in the colon. At present, the effects of dietary AGEs on intestinal flora are inconsistent, which may be due to the formation of other compounds in food during heating. This review summarizes the sources and absorption of AGEs and its relationship with metabolic related diseases, as well as the effects of human and animal studies on the gut microorganisms and and their metabolite composition.

参考文献/References:

[1] Rungratanawanich W,Qu Y,Wang X,et al.Advanced glycation end products(AGEs)and other adducts in aging-related diseases and alcohol-mediated tissue injury[J].Exp Mol Med,2021,53(2):168-188.DOI:10.1038/s12276-021-00561-7.
[2] van der Lugt T,Opperhuizen A,Bast A,et al.Dietary Advanced Glycation Endproducts and the Gastrointestinal Tract[J].Nutrients,2020,12(9):2814.DOI:10.3390/nu12092814.
[3] Mastrocola R,Collotta D,Gaudioso G,et al.Effects of exogenous dietary advanced glycation end products on the Cross-Talk mechanisms linking microbiota to metabolic inflammation[J].Nutrients,2020,12(9):2497.DOI:10.3390/nu12092497.
[4] Sri Harsha PSC,Lavelli V.Use of Grape Pomace Phenolics to Counteract Endogenous and Exogenous Formation of Advanced Glycation End-Products[J].Nutrients,2019,11(8):1917.DOI:10.3390/nu11081917.
[5] Gill V,Kumar V,Singh K,et al.Advanced glycation end products(AGEs)may be a striking link between modern diet and health[J].Biomolecules,2019,9(12):888.DOI:10.3390/biom9120888.
[6] Hellwig M,Geissler S,Matthes R,et al.Transport of free and peptide-bound glycated amino acids:synthesis,transepithelial flux at Caco-2 cell monolayers,and interaction with apical membrane transport proteins[J].Chembiochem,2011,12(8):1270-1279.DOI:10.1002/cbic.201000759.
[7] Hellwig M,Auerbach C,Müller N,et al.Metabolization of the Advanced Glycation End Product N-ε-Carboxymethyllysine(CML)by Different Probiotic E.coli Strains[J].J Agric Food Chem,2019,67(7):1963-1972.DOI:10.1021/acs.jafc.8b06748.
[8] Garay-Sevilla ME,Rojas A,Portero-Otin M,et al.Dietary AGEs as ExogenousBoosters of Inflammation[J].Nutrients,2021,13(8):2802.DOI:10.3390/nu13082802.
[9] Yubero-Serrano EM,Gutiérrez-Mariscal FM,Gómez-Luna P,et al.Dietary modulation of advanced glycation end products metabolism on carotid intima-media thickness in type 2 diabetes patients:From the CORDIOPREV study[J].Clin Investig Arterioscler,2022,S0214-9168(22)00113-9.DOI:10.1016/j.arteri.2022.08.004.
[10] Lotan R,Ganmore I,Livny A,et al.Design and feasibility of a randomized controlled pilot trial to reduce exposure and cognitive risk associated with advanced glycation end products in older adults with type 2 diabetes[J].Front Nutr,2021,8:614149.DOI:10.3389/fnut.2021.614149.
[11] Oliveira JS,de Almeida C,de Souza ÂMN,et al.Effect of dietary advanced glycation end-products restriction on type 2 diabetes mellitus control:a systematic review[J].Nutr Rev,2022,80(2):294-305.DOI:10.1093/nutrit/nuab020.
[12] Ghorbaninejad P,Djafarian K,Babaee N,et al.A negative association of dietary advanced glycation end products with obesity and body composition in Iranian adults[J].Br J Nutr,2021,125(4):471-480.DOI:10.1017/S0007114520002871.
[13] Baye E,Kiriakova V,Uribarri J,et al.Consumption of diets with low advanced glycation end products improves cardiometabolic parameters:meta-analysis of randomised controlled trials[J].Sci Rep,2017,7(1):2266.DOI:10.1038/s41598-017-02268-0.
[14] Mills DJ,Tuohy KM,Booth J,et al.Dietary glycated protein modulates the colonic microbiota towards a more detrimental composition in ulcerative colitis patients and non-ulcerative colitis subjects[J].J Appl Microbiol,2008,105(3):706-714.DOI:10.1111/j.1365-2672.2008.03783.x.
[15] S'witecka D,Narbad A,Ridgway KP,et al.The study on the impact of glycated pea proteins on human intestinal bacteria[J].Int J Food Microbiol,2011,145(1):267-272.DOI:10.1016/j.ijfoodmicro.2011.01.002.
[16] Dell'Aquila C,Ames J,Gibson G,et al.Fermentation of heated gluten systems by gut microflora[J].European Food Research & Technology,2003,217(5):382-386.DOI:10.1007/s00217-003-0773-5.
[17] Borrelli RC,Fogliano V.Bread crust melanoidins as potential prebiotic ingredients[J].Mol Nutr Food Res,2005,49(7):673-678.DOI:10.1002/mnfr.200500011.
[18] Helou C,Denis S,Spatz M,et al.Insights into bread melanoidins:fate in the upper digestive tract and impact on the gut microbiota using in vitro systems[J].Food Funct,2015,6(12):3737-3745.DOI:10.1039/c5fo00836k.
[19] Seiquer I,Rubio LA,Peinado MJ,et al.Maillard reaction products modulate gut microbiota composition in adolescents[J].Mol Nutr Food Res,2014,58(7):1552-1560.DOI:10.1002/mnfr.201300847.
[20] Yacoub R,Nugent M,Cai W,et al.Advanced glycation end products dietary restriction effects on bacterial gut microbiota in peritoneal dialysis patients; a randomized open label controlled trial[J].PLoS One,2017,12(9):e0184789.DOI:10.1371/journal.pone.0184789.
[21] Delgado-Andrade C,Pastoriza de la Cueva S,Peinado MJ,et al.Modifications in bacterial groups and short chain fatty acid production in the gut of healthy adult rats after long-term consumption of dietary Maillard reaction products[J].Food Res Int,2017,100(Pt 1):134-142.DOI:10.1016/j.foodres.2017.06.067.
[22] Qu W,Yuan X,Zhao J,et al.Dietary advanced glycation end products modify gut microbial composition and partially increase colon permeability in rats[J].Mol Nutr Food Res,2017,61(10).DOI:10.1002/mnfr.201700118.
[23] Helou C,Anton PM,Niquet-Léridon C,et al.Fecal excretion of Maillard reaction products and the gut microbiota composition of rats fed with bread crust or bread crumb[J].Food Funct,2017,8(8):2722-2730.DOI:10.1039/c7fo00430c.
[24] Sharma JK,Sihmar M,Santal AR,et al.Barley Melanoidins:key dietary compounds with potential health benefits[J].Front Nutr,2021,8:708194.DOI:10.3389/fnut.2021.708194.
[25] Yang Y,Wu H,Dong S,et al.Glycation of fish protein impacts its fermentation metabolites and gut microbiota during in vitro human colonic fermentation[J].Food Res Int,2018,113:189-196.DOI:10.1016/j.foodres.2018.07.015.

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备注/Memo

备注/Memo:
通信作者:徐积兄,Email:Jixiong.Xu@ncu.edu.cn
基金项目:江西省研究生创新基金支持(YC2021-B055)
更新日期/Last Update: 2023-01-30