[1]周芳鸣,鲁一兵.工程菌在代谢性疾病治疗中应用的研究进展[J].国际内分泌代谢杂志,2023,43(01):6-9.[doi:10.3760/cma.j.cn121383-20210322-03057]
 Zhou Fangming,Lu Yibing..Research progress of engineering bacteria in the treatment of metabolic diseases[J].International Journal of Endocrinology and Metabolism,2023,43(01):6-9.[doi:10.3760/cma.j.cn121383-20210322-03057]
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工程菌在代谢性疾病治疗中应用的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年01期
页码:
6-9
栏目:
肠道菌群与代谢性疾病专题
出版日期:
2023-01-20

文章信息/Info

Title:
Research progress of engineering bacteria in the treatment of metabolic diseases
作者:
周芳鸣鲁一兵
南京医科大学第二附属医院内分泌科,南京 210011
Author(s):
Zhou Fangming Lu Yibing.
Department of Endocrinology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China
关键词:
工程菌 代谢性疾病 糖尿病 肥胖
Keywords:
Engineering bacteria Metabolic diseases Diabetes mellitus Obesity
DOI:
10.3760/cma.j.cn121383-20210322-03057
摘要:
工程菌,即改造的肠道微生物,合成生物学利用各类编辑工具和回路设计控制其行为,对机体产生特定的影响,从而在代谢性疾病的治疗中精准发挥作用。对于代谢性疾病,包括糖尿病、肥胖、高脂血症、高尿酸血症、高氨血症及苯丙酮尿症,已有研究成功构建相关工程菌,通过分泌特定的治疗因子,能够针对疾病的发病机制对机体产生有益影响,有少量研究已进入临床试验。
Abstract:
Engineering bacteria, that is, modified intestinal microorganisms, use various editing tools and circuit design to control their behavior, and have a specific impact on the body, so as to play a precise role in the treatment of metabolic diseases. For metabolic diseases, including diabetes, obesity, hyperlipidemia, hyperuricemia, hyperammonemia and phenylketonuria, related engineering bacteria have been successfully constructed. By secreting specific therapeutic factors, engineering bacteria can have beneficial effects on the body according to the pathogenesis of diseases. A small number of studies have entered clinical trials.

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备注/Memo

备注/Memo:
通信作者:鲁一兵,Email: luyibing2004@126.com
基金项目:江苏省卫生健康委科研项目(ZDB2020034)
更新日期/Last Update: 2023-01-30