[1]祝凌妃,杨震,秦利.肌肉因子与代谢性疾病[J].国际内分泌代谢杂志,2016,36(05):355-358.[doi:10.3760/cma.j.issn.1673-4157.2016.05.19]
 Zhu Lingfei,Yang Zhen,Qin li.Myokines and metabolic disease[J].International Journal of Endocrinology and Metabolism,2016,36(05):355-358.[doi:10.3760/cma.j.issn.1673-4157.2016.05.19]
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肌肉因子与代谢性疾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年05期
页码:
355-358
栏目:
综述
出版日期:
2016-09-20

文章信息/Info

Title:
Myokines and metabolic disease
作者:
祝凌妃杨震秦利
200092 上海交通大学医学院附属新华医院内分泌科
Author(s):
Zhu Lingfei Yang Zhen Qin li
Department of Endocrinology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, to Shanghai 200092, China
关键词:
肌肉因子 骨骼肌 代谢性疾病
Keywords:
Myokine Skeletal muscle Metabolic disease
DOI:
10.3760/cma.j.issn.1673-4157.2016.05.19
摘要:
近来的研究发现,骨骼肌不仅是人体重要的运动器官,也是活跃的内分泌器官。肌肉因子(myokine) 是指由骨骼肌合成、分泌的细胞因子和活性多肽。肌肉因子不仅可以作用于骨骼肌本身,还可通过血液循环到 达外周,作用于肝脏、脂肪、心脏等器官,调节机体的代谢。研究表明,肌肉因子与肥胖、2型糖尿病、代谢综合 征等代谢相关性疾病的发生、发展密切相关,可能是治疗代谢性疾病的潜在靶点。
Abstract:
Skeletal muscle represents the largest organ of the body in non-obese individuals and is now considered to be an active endocrine organ. Those cytokines and peptides expressed by and released from skeletal muscle have been termed myokines. Myokines have been shown to affect muscle physiology and additionally exert systemic effects on the liver, adipose tissue, brain and other organs. Recent data suggest that myokines may play a key role in the initiation and progression of obesity, type 2 diabetes, metabolic syndrome and other metabolic diseases.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81370953); 上海市卫生系统培养计划(XYQ2013098); 上海市科学技术 委员会科研计划项目(14ZR1427400) 通信作者:秦利,Email:qinli@medmail.com.cn
更新日期/Last Update: 2016-11-20