[1]林金丹 闫爽.长链非编码RNA调控脂肪形成的研究进展[J].国际内分泌代谢杂志,2020,40(04):237-240.[doi:10.3760/cma.j.issn.1673-4157.2020.04.005]
　Lin Jindan,Yan Shuang.Advances in the regulation of long non-coding RNA on adipogenesis[J].International Journal of Endocrinology and Metabolism,2020,40(04):237-240.[doi:10.3760/cma.j.issn.1673-4157.2020.04.005]
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长链非编码RNA调控脂肪形成的研究进展
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
40
期数:
2020年04期
页码:
237-240
栏目:
综述
出版日期:
2020-07-20

文章信息/Info

Title:
Advances in the regulation of long non-coding RNA on adipogenesis
作者:
林金丹 闫爽
哈尔滨医科大学附属第四医院内分泌代谢科 150001
Author(s):
Lin Jindan;  Yan Shuang
Department of Endocrinology and Metabolism, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China
关键词:
长链非编码RNA;  脂肪细胞;  脂肪形成
Keywords:
Long non-coding RNA;  Adipocyte;  Adipogenesis
DOI:
10.3760/cma.j.issn.1673-4157.2020.04.005
摘要:
长链非编码RNA(lncRNA)是一种长度超过200个核苷酸的非编码RNA,在多种生物学过程中起着传递信号、发挥向导、诱饵和支架等功能。大量研究证明,lncRNA可调控参与脂肪形成的一些关键因子,从而正向或负向调控白色和棕色脂肪的形成。它与腰围、腰臀比、空腹胰岛素和体重指数等相关,还参与炎性反应、肝脂肪变性及纤维化等过程。LncRNA可作为一种肥胖及相关代谢性疾病相关的新型生物标志物或治疗靶点,具有潜在且巨大的临床价值。
Abstract:
Long non-coding RNA(lncRNA)is a kind of non-coding RNA, with a length of more than 200 bp, which plays roles in signal transmission, guide, decoy and scaffold in a variety of biological processes. A large number of studies have proved that lncRNA can regulate some key factors involved in adipogenesis to positively or negatively regulate the formation of white and brown fat. It is closely related to waist circumference, waist-to-hip ratio, fasting insulin and body mass index, and is also involved in the process of inflammation, liver steatosis and fibrosis. LncRNA can be used as a new biomarker or therapeutic target related to obesity and related metabolic diseases, which has potential and great clinical value.

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备注/Memo

备注/Memo:
通信作者:闫爽,Email:qingmei0724@163.com
基金项目:中国健康促进基金会资助研究项目(CHPF-2017-LXSCD); 2016年度哈尔滨医科大学附属第四医院第二届重点基金(HYDSYYZ201601)
Corresponding author: Yan Shuang, Email:qingmei0724@163.com
Fund program:The China Health Promotion Foundation Fund Research Project(CHPF-2017-LXSCD); The Second Key Fund of The Fourth Affiliated Hospital of Harbin Medical University in 2016(HYDSYYZ201601)
更新日期/Last Update: 2020-07-20