[1]许瀚元 朱惠娟 龚凤英.恒定自然杀伤细胞与肥胖[J].国际内分泌代谢杂志,2019,39(01):40-44.[doi:10.3760/cma.j.issn.1673-4157.2019.01.010]
　Xu Hanyuan,Zhu Huijuan,Gong Fengying.Invariant natural killer T cells and obesity[J].International Journal of Endocrinology and Metabolism,2019,39(01):40-44.[doi:10.3760/cma.j.issn.1673-4157.2019.01.010]
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恒定自然杀伤细胞与肥胖()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年01期
页码:
40-44
栏目:
综述
出版日期:
2019-01-20

文章信息/Info

Title:
Invariant natural killer T cells and obesity
作者:
许瀚元 朱惠娟 龚凤英
中国医学科学院,北京协和医学院,北京协和医院内分泌科,卫生健康委内分泌重点实验室,协和转化医学中心 100730
Author(s):
Xu Hanyuan;  Zhu Huijuan;  Gong Fengying
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China
关键词:
恒定自然杀伤细胞;  肥胖;  脂肪组织;  炎症;  巨噬细胞
Keywords:
Invariant natural killer T cells;  Obesity;  Adipose tissue;  Inflammation;  Macrophages
DOI:
10.3760/cma.j.issn.1673-4157.2019.01.010
摘要:
恒定自然杀伤细胞(iNKT细胞)是广泛分布于肝脏、脾脏、骨髓等组织中的一类特殊的T淋巴细胞亚群。2009年,Lynch等首次报道在人网膜脂肪组织中存在iNKT细胞,并发现其表达的表面标志与其他外周组织内iNKT细胞不相同。当脂肪组织中的iNKT细胞被激活后,能发挥调节脂肪组织免疫微环境的作用。研究表明,在肥胖患者及高脂饮食诱导肥胖小鼠中,脂肪组织内iNKT细胞的数量明显下降,体重减轻后,细胞数量回升。缺乏iNKT细胞的小鼠体重呈增加的趋势,同时其脂肪组织内促炎型巨噬细胞及炎性细胞因子的水平升高,并出现糖耐量受损等代谢异常; 而激活iNKT细胞,则能够通过促进白色脂肪棕色化,增加产热,使小鼠体重减轻。因此,由于iNKT细胞与肥胖及脂肪组织炎性反应的密切关系,其有望在未来成为改善肥胖及相关代谢异常的新靶点。
Abstract:
Invariant natural killer T cells(iNKT cells)are special kinds of T lymphocyte subset which widely distributed in liver, spleen, bone marrow and other tissues. In 2009, Lynch et al first reported the presence of iNKT cells in human omental adipose tissue, and its surface markers were quite different from that of the iNKT cells dwelled in other peripheral tissues. Once activated, iNKT cells are capable of regulating the immunological microenvironment within adipose tissue. It is reported that numbers of iNKT cells in adipose tissue were significantly decreased in obese patients and high fat diet-induced obese mice.However, the amount of iNKT cells can be restored after weight loss. Studies showed that the mice models lacking iNKT cells were more likely to gain weight. The levels of pro-inflammatory macrophages and cytokines in adipose tissue were increased and metabolic abnormalities such as impaired glucose tolerance were observed. The activation of iNKT cells in mice was found to be able to promote browning of white adipose tissue, which then increased heat production and subsequently led to weight loss. Therefore, due to the close relationship among iNKT cells, adipose tissue inflammation and obesity, it is expected that iNKT cells can be utilized as a promising target in the treatment of obesity and related metabolic abnormalities in the future.

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备注/Memo

备注/Memo:
通信作者:龚凤英,Email:fygong@sina.com
基金项目:国家自然科学基金(30540036,30771026,81370898); 北京市自然科学基金(7082079,7182130); 人社部留学人员科技活动项目择优资助经费(启动类); 国家临床重点专科建设项目单位(WBYZ2011-873); 协和中青年基金项目(2013-020)
Corresponding author: Gong Fengying,Email:fygong@sina.com
Fund program:National Natural Science Foundation of China(30540036,30771026,81370898); Natural Science Foundation of Beijing(7082079,7182130); Scientific Research Foundation for the Selected Returned Overseas Chinese Scholars, The Ministry of Human Resources and Social Security of China; The Program of National Key Clinical Specialty Construction(WBYZ2011-873); PUMCH Foundation(2013-020)
更新日期/Last Update: 2019-01-20