[1]唐榕 木良善.Akkermansia.muciniphila与代谢性疾病[J].国际内分泌代谢杂志,2018,38(01):36-29.[doi:10.3760/cma.j.issn.1673-4157.2018.01.010]
 Tang Rong*,Mu Liangshan.Akkermansia.muciniphila and metabolic diseases[J].International Journal of Endocrinology and Metabolism,2018,38(01):36-29.[doi:10.3760/cma.j.issn.1673-4157.2018.01.010]
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Akkermansia.muciniphila与代谢性疾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年01期
页码:
36-29
栏目:
综述
出版日期:
2018-01-20

文章信息/Info

Title:
Akkermansia.muciniphila and metabolic diseases
作者:
唐榕 木良善
325000 温州医科大学第二临床医学院(唐榕); 325000 温州医科大学附属第一医院生殖医学中心(木良善)
Author(s):
Tang Rong*Mu Liangshan
*The Second School of Medicine,Wenzhou Medical University,Wenzhou 325000,China
关键词:
肠道菌群 Akkermansia.muciniphila 糖尿病 肥胖
Keywords:
Gut microbiota Akkermansia.muciniphila Diabetes mellitus Obesity
DOI:
10.3760/cma.j.issn.1673-4157.2018.01.010
摘要:
代谢性疾病的发生与肠道菌群失调密切相关。许多研究表明,Akkermansia.muciniphila(A.muciniphila)的定植可降低肠道屏障的通透性,有效地防止慢性低度炎性反应的发生,并且与机体糖代谢、脂代谢以及氨基酸代谢密切相关。糖尿病、肥胖等代谢性疾病患者体内的A.muciniphila丰度下降,补充后代谢状态改善。正确地认识A.muciniphila与代谢疾病的相关性及其发挥作用的机制,有利于为肥胖、糖尿病等代谢性疾病的治疗提供新的靶点和思路。
Abstract:
Gut microbiota is found to be associated with metabolic diseases. Many studies have shown that the colonization of Akkermansia.muciniphila(A.muciniphila)can reduce the permeability of intestinal barrier,which effectively prevent the occurrence of chronic low-grade inflammation, and is closely related to glucose metabolism, lipid metabolism and amino acid metabolism. The abundance of A.muciniphila in patients with diabetes, obesity and other metabolic diseases is decreased, and the metabolic state is improved after supplementation.A correct understanding of the relationship between A.muciniphila and metabolic diseases as well as mechanism will help to provide new targets and ideas for the treatment of metabolic diseases such as obesity and diabetes.

参考文献/References:


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备注/Memo

备注/Memo:

通信作者:木良善,Email:liangshanmu@hotmail.com
更新日期/Last Update: 2018-01-30