[1]王姝洁,张翼飞,张志国.雷公藤红素在治疗代谢综合征中的作用及相关机制[J].国际内分泌代谢杂志,2017,37(04):258-261.
 Wang Shujie,Zhang Yifei,Zhang Zhiguo..Effects and related mechanisms of celastrol in the treatment of metabolic syndrome[J].International Journal of Endocrinology and Metabolism,2017,37(04):258-261.
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雷公藤红素在治疗代谢综合征中的作用及相关机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年04期
页码:
258-261
栏目:
综述
出版日期:
2017-07-20

文章信息/Info

Title:
Effects and related mechanisms of celastrol in the treatment of metabolic syndrome
作者:
王姝洁张翼飞张志国
200025 上海交通大学医学院附属瑞金医院内分泌代谢病科,上海市内分泌代谢病临床医学中心
Author(s):
Wang Shujie Zhang Yifei Zhang Zhiguo.
Department of Endocrinology and Metabolism, Shanghai Ruijin Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Clinical Center for Endocrine and Metabolism Diseases, Shanghai 200025, China
关键词:
雷公藤红素 代谢综合征 胰岛素抵抗 瘦素
Keywords:
Celastrol Metabolic syndrome Insulin resistance Leptin
文献标志码:
A
摘要:
雷公藤红素是从中药雷公藤的根皮中分离得到的有效成分之一,具有抗肿瘤、抗病毒、免疫抑制等活性。最近研究发现,其可通过改善胰岛素抵抗,增加瘦素受体敏感性和能量消耗,抑制脂肪细胞分化,抗炎和抗氧化等机制减轻体重和改善糖、脂代谢,表明雷公藤红素在治疗代谢综合征及相关异常中具有潜在作用。
Abstract:
Celastrol, one of the most promising medicinal ingredient extracted from the root of Tripterygiumwilfordii Hook, possesses anti-tumor, anti-virus and immunosuppressive effect. Recent researches showed its effects on reducing body weight, alleviating glucose and lipid, the possible mechanisms included reversing insulin resistance, increasing leptin sensitivity and energy expenditure, inhibiting adipocyte differentiation, anti-inflammatory, anti-oxidant and so on. It indicates celastrol plays potential roles in the treatment of metabolic syndrome and related dysfunction.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81471074); 上海市人才发展基金项目(201554)
通信作者:张翼飞,Email:feifei-a@163.com
更新日期/Last Update: 2017-07-30