[1]李津凯,阚世廉,张秀军,等.前列地尔联合胰激肽原酶治疗早期 糖尿病足的疗效观察[J].国际内分泌代谢杂志,2016,36(02):121-123.[doi:10.3760/cma.j.issn.1673-4157.2016.02.011]
　Li Jinkai*,Kan Shilian,Zhang Xiujun,et al.Curative effect of alprostadil combined with kallidinogenase on early diabetic foot[J].International Journal of Endocrinology and Metabolism,2016,36(02):121-123.[doi:10.3760/cma.j.issn.1673-4157.2016.02.011]
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前列地尔联合胰激肽原酶治疗早期 糖尿病足的疗效观察()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年02期
页码:
121-123
栏目:
短篇论著
出版日期:
2016-03-20

文章信息/Info

Title:
Curative effect of alprostadil combined with kallidinogenase on early diabetic foot
作者:
李津凯; 阚世廉; 张秀军; 李俊海; 黄梅
300070 天津医科大学研究生院(李津凯,阚世廉); 300211 天津医院血管外科(李津凯,张秀军,李俊海,黄梅)
Author(s):
Li Jinkai*; Kan Shilian; Zhang Xiujun; Li Junhai; Huang Mei.
*Graduated School,Tianjin Medical University,Tianjin 300070,China
关键词:
前列地尔;  胰激肽原酶;  糖尿病足
Keywords:
Alprostadil;  Kallidinogenase;  Diabetic foot
DOI:
10.3760/cma.j.issn.1673-4157.2016.02.011
摘要:
目的 探究前列地尔联合注射用胰激肽原酶治疗早期糖尿病足的临床疗效。方法 120例早期糖尿病足患者按照随机数字表法分成3组,每组40例。A组给予前列地尔10 μg+生理盐水20 ml静脉推注,B组给予注射用水1.5 ml+注射用胰激肽原酶40 IU肌肉注射,C组予前列地尔10 μg和胰激肽原酶40 IU联合应用,3组治疗均为1 次/d,连续给药4周后比较3组的临床疗效并记录3组患者治疗前、后踝肱指数及足背动脉流速数据。结果 治疗后C组总有效率(95%)显著高于A组(77.5%)和B组(75%)(χ2=6.580,P<0.05),且踝肱指数和足背动脉流速亦高于A组和B组(χ2=24.59,95.99,P均<0.05)。结论 前列地尔联合胰激肽原酶是治疗早期糖尿病足较为理想的配伍方案。
Abstract:
Objective To observe the curative effect of alprostadil combined with kallidinogenase on early diabetic foot. Methods A total of 120 patients with diabetic foot were divided into three groups according to the random number table method,with 40 patients in each group.Patients in group A were intravenous injected with 10 μg alprostadil and 20 ml sodium chloride,patients in group B were intramuscular injected with 1.5 ml water and 40 IU kallidinogenase,10 μg alprostadil combined with 40 IU kallidinogenase were applied in group C. Drug administration in 3 groups were all performed once per day and continued for 4 weeks. Clinical efficacy among the three groups were compared. Ankle brachial pressure index and the dorsalis pedis artery flow velocity before and after medication were recorded among the three groups. Results Total effective rate in group C(95%)was significantly higher than those in group A(77.5%)and group B(75%,χ2=6.580,P<0.05),ankle brachial index and the dorsalis pedis artery blood flow velocity in group C were higher than those in group A and group B(χ2=24.59, 95.99, all P<0.05)after treatment. Conclusion Alprostadil combined with kallidinogenase is one of the ideal compatibility solutions for the treatment of early diabetic foot.

参考文献/References:

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更新日期/Last Update: 2016-03-20