[1]郝圆圆,张婷婷,袁红网,等.增食欲素干预单纯性肥胖的作用及机制[J].国际内分泌代谢杂志,2014,(05):324-326.[doi:10.3760/cma.j.issn.1673-4157.2014.05.010]
 Hao Yuanyuan,Zhang Tingting,Yuan Hongwang,et al.Effects of orexin on obesity and its mechanism[J].International Journal of Endocrinology and Metabolism,2014,(05):324-326.[doi:10.3760/cma.j.issn.1673-4157.2014.05.010]
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增食欲素干预单纯性肥胖的作用及机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年05期
页码:
324-326
栏目:
综述
出版日期:
2014-10-31

文章信息/Info

Title:
Effects of orexin on obesity and its mechanism
作者:
郝圆圆张婷婷袁红网唐丽娟胡弘毅陈曦秦阳卜平
225001 扬州大学医学院
Author(s):
Hao Yuanyuan Zhang Tingting Yuan Hongwang Tang Lijuan Hu Hongyi Chen Xi Qin YangBo Ping.
Yangzhou University College of Medicine, Yangzhou 225001, China Corresponding author: Bu Ping,Email: Boping1955@hotmail.com
关键词:
增食欲素 肥胖 运动
Keywords:
Orexin Obesity Physical activity
DOI:
10.3760/cma.j.issn.1673-4157.2014.05.010
摘要:
增食欲素作为一种调节进食与能量代谢等生理功能的重要中枢神经肽,与多种神经递质构成中枢调控网络,促进进食,抑制胃肠蠕动,增强胃酸分泌。增食欲素对机体自发运动有向上调节作用,且比促食作用更明显,从而增加机体非运动活动产热,影响休息/非休息能量消耗比。此外增食欲素还能提高褐色脂肪组织的生热作用,共同增强机体能量消耗,干预肥胖发展。
Abstract:
Orexin, a significant central neuropeptide, homeostatically coordinates multiple physiological functions, including feeding behavior and energy metabolism. In the context of a brain regulation network, orexin plays a key role in increasing food intake, inhibiting gastrointestinal motility and promoting the secretion of gastric acid, working with several kinds of neurotransmitters. The elevated orexin may result in the increase of spontaneous physical activity,which is greater than orexigenic effects. The greater activation of orexin-induced spontaneous physical activity may raise nonexercise activity thermogenesis and affect the resting/non-resting energy expenditure ratio. Orexin may enhance brown adipose tissue thermogenesis energy expenditure,therefore intervene the development of obesity.

参考文献/References:

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备注/Memo

备注/Memo:
通信作者:卜平,Email:Boping1955@hotmail.com
更新日期/Last Update: 2014-09-20