[1]魏薇,王卫庆.库欣病的分子发病机制[J].国际内分泌代谢杂志,2014,(03):203-206.[doi:10.3760/cma.j.issn.1673-4157.2014.03.017]
 Wei Wei,Wang Weiqing..The molecular pathogenesis of Cushing's disease[J].International Journal of Endocrinology and Metabolism,2014,(03):203-206.[doi:10.3760/cma.j.issn.1673-4157.2014.03.017]
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库欣病的分子发病机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年03期
页码:
203-206
栏目:
综述(基础研究)
出版日期:
2014-06-30

文章信息/Info

Title:
The molecular pathogenesis of Cushing's disease
作者:
魏薇王卫庆
200025 上海交通大学医学院附属瑞金医院内分泌代谢病科,上海市内分泌代谢病临床医学中心   
Author(s):
Wei WeiWang Weiqing.
Department of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University,Shanghai 200025, China Corresponding author: Wang Weiqing, Email: wqingw@hotmail.c
关键词:
库欣病基因突变基因表达异常受体-配体异常表达
Keywords:
Cushing's diseaseGene mutationAbnormal gene expressionAbnormal expression of receptors and ligands
DOI:
10.3760/cma.j.issn.1673-4157.2014.03.017
摘要:
库欣病是垂体促肾上腺皮质激素(ACTH)腺瘤分泌过多ACTH,刺激肾上腺过度合成和分泌糖皮质激素所致。家族性内分泌综合征伴垂体ACTH腺瘤与多发性内分泌腺瘤病(MEN)-1及GNAS1基因突变相关。散发性库欣病的发病机制涉及PTTG、p27基因和激素相关受体、配体的异常表达,造成垂体ACTH细胞的过度增殖和激素分泌。进一步了解库欣病的分子发病机制对早期诊断和靶向治疗有重要意义。
Abstract:
Cushing's disease is a condition of an excess of the steroid hormone cortisol in the blood caused by a pituitary corticotropic adenoma secreting adrenocorticotropic hormone. Cushing's disease in familial endocrine syndromes with pituitary adenomas is related to the gene mutation of MEN-1 and GNAS1. And the abnormal expression of the PTTG and p27 genes,hormone related receptors and ligands are involved in the pathogenesis of sporadic Cushing's disease,which cause the proliferation of the corticotroph cells and excessive ACTH secretion. Further understanding of the molecular pathogenesis of Cushing's disease is helpful in early diagnosis and targeted therapy.

参考文献/References:

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备注/Memo

备注/Memo:
通信作者:王卫庆,Email:wqingw@hotmail.com
更新日期/Last Update: 2014-05-20