[1]韩颖,李素芬,刘艳.血清胱抑素C与糖尿病肾病[J].国际内分泌代谢杂志,2014,(03):207-210.[doi:10.3760/cma.j.issn.1673-4157.2014.03.018]
　Han Ying,Li Sufen,Liu Yan..Relationship between serum cystatin C and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2014,(03):207-210.[doi:10.3760/cma.j.issn.1673-4157.2014.03.018]
点击复制

血清胱抑素C与糖尿病肾病()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年03期
页码:
207-210
栏目:
小论坛
出版日期:
2014-06-30

文章信息/Info

Title:
Relationship between serum cystatin C and diabetic nephropathy
作者:
韩颖; 李素芬; 刘艳
300280　天津,大港油田总医院内分泌科
Author(s):
Han Ying; Li Sufen; Liu Yan.
Department of Endocrinology,Dagang Oil Field General Hospital,Tianjin 300280,China
关键词:
胱抑素C; 糖尿病肾病; 肾小球滤过率
Keywords:
Cystatin C; Diabetic nephropathy; Glomerular filtration rate
DOI:
10.3760/cma.j.issn.1673-4157.2014.03.018
摘要:
血清胱抑素C是一种半胱氨酸蛋白酶抑制剂,由机体所有有核细胞以恒定的速率产生,其相对分子质量小,可被肾小球自由滤过,在近端肾小管被代谢。血清胱抑素C作为一种内源性标志物,可以较早的反映肾小球滤过率的变化,故其在糖尿病肾病早期诊断中有重要的价值。
Abstract:
Cystatin C,a cysteine proteinase inhibitor, is produced at a constant rate by nucleated cells,and is freely filtered by the renal glomeruli,metabolized by the proximal tubule.As an endogenous serum markers,cystatin C can reflect the early changes of glomerular filtration rate,so it has important value in early diagnosis of diabetic nephropathy.

参考文献/References:

　[1]　Yang W,Lu J,Weng J,et al.Prevalence of diabetes among men and women in China[J].N Engl J Med,2010,362（12）：1090-1010. 　
[2]　赵龙,关广聚.糖尿病肾病发病机制研究进展[J].中华肾脏病杂志,2013,29（7）：554-558. 　
[3]　何煜.胱抑素C与2型糖尿病慢性并发症关系的研究进展[J].医学综述,2013,19（11）：2032-2035. 　
[4]　黄秀丽,张惠莉,高继东.血清胱抑素C在早期糖尿病肾病诊断中的价值[J].中国医学前沿杂志（电子版）,2010,2（3）：76-79. 　
[5]　向礼贤.血清胱抑素C检测与疾病[J].四川医学,2004,25（11）：1258-1259. 　
[6]　Aksun SA,Ozmen D,Ozmen B,et al.β2-microglobulin and cystatin C in type 2 diabetes：assessmet of diabetic nephropathy[J].Exp Clin Endocrinol Diabetes,2004,112（4）：195-200. 　
[7]　Wei L,Ye X,Pei X,et al.Reference intervals for serum cystatin C and factors influencing cystatin C levels other than renal function in the elderly[J].PLoS One,2014,9（1）：e86066. 　
[8]　傅美华,陈军,陈秋.胱抑素C与糖尿病肾病的相关研究进展[J].中国全科医学,2013,16（2）：229-231. 　
[9]　柯浩珍. β2-微球蛋白检测的临床意义[J].青海医药杂志,2013, 43（1）：78-79.
[10]　涂良水,詹爱霞. 糖尿病肾病患者血清胱抑素C及同型半胱氨酸的变化及相关性研究[J].实用医学杂志,2009,25（8）：1262-1263.
[11]　朱建锋,瞿亚红,陈佳英. 尿微量白蛋白和血清胱抑素C 检测对糖尿病肾病早期诊断的意义[J].中国基层医药,2010；17（4）：491-492.
[12]　俸家富,张林.基于血清胱抑素C水平评估肾小球滤过率的研究进展[J].国际检验医学杂志,2010,31（4）：354-356.
[13]　Lee BW,Ihm SH,Choi MG,et al.The comparison of cystatin C and creatinine as an accurate serum marker in the prediction of type 2 diabetic nephropathy[J].Diabetes Res Clin Pract,2007, 78（3）：428-434.
[14]　Shlipak MG,Sarnak MJ,Katz R,et al.Cystatin C and the risk of death and cardiovascular events among elderly persons[J].N Engl J Med,2005,352（20）：2049-2060.
[15]　何俊英,赵升,应漂漂,等.血清半胱氨酸蛋白酶抑制剂C评价肾病早期肾损害的研究[J].检验医学,2009,24（6）：476-477.
[16]　Yoo JS,Lee YM,Lee EH,et al.Serum cystatin C reflects the progress of albuminuria[J].Diabetes Metab J,2011,35（6）：602-609.
[17]　田静,刘娟,田刚.血清胱抑素C与糖尿病肾病的相关性研究[J]. 陕西医学杂志,2013,12：1643-1645.
[18]　Jeon YK,Kim MR,Huh JE,et al.Cystatin C as an early biomarker of nephropathy in patients with type 2 diabetes[J].J Korean Med Sci,2011,26（2）：258-263.
[19]　徐静,贾爱华,张春虹,等. 血清胱抑素C与糖尿病肾病的关系[J]. 中国糖尿病杂志,2009,17（8）：613-615.
[20]　Willems D,Wolff F,Mekahli F,et al.Cystatin C for early detection of renal impairment in diabetes[J].Clin Biochem,2009,42 （1-2）：108-110.
[21]　Pavkov ME,Knowler WC,Hanson RL,et al.Comparison of serum cystatin C,serum creatinine,measured GFR,and estimated GFR to assess the risk of kidney failure in American Indians with diabetic nephropathy[J].Am J Kidney Dis,2013,62（1）：33-41.
[22]　Rigalleau V,Beauvieux MC,Le Moigne F,et al.Cystatin C improves the diagnosis and stratification of chronic kidney dis-ease,and the estimation of glomerular filtration rate in diabetes[J].Diabetes Metab,2008,34 （5）：482-489.
[23]　彭建明,陈艳玲,官燕飞,等.甲状腺功能失调对血清胱抑素C及肌酐水平的影响[J].国际检验医学杂志,2013,34（1）：42-43.
[24]　曾玉琴,朱建勇,胡伟林,等.甲状腺功能对血清胱抑素C水平的影响[J].中华实用诊断与治疗杂志,2012,26（2）：147-148.
[25]　Schmid C,Ghirlanda-Keller C,Zwimpfer C,et al.Triiodothyronine stimulates cystatin C production in bone cells[J].Biochem Biophys Res Commun,2012,419（2）：425-430.
[26]　Mendiluce A,Bustamante J,Martin D,et al.Cystatin C as a marker of renal function in kidney transplant patients[J].Transplant Proc,2005,37（9）：3844-3847.
[27]　Krolewski AS,Warram JH,Forsblom C,et al.Serum concentration of cystatin C and risk of end-stage renal disease in diabetes[J]. Diabetes Care,2012,35（11）：2311-2316.
[28]　蔡文慧.血清胱抑素C浓度在2型糖尿病肾病早期诊断中的临床价值[J].临床和实验医学杂志,2011,10（4）：255-256.
[29]　吴伟琼,向薇,夏晓英. NT-ProBNP、血清胱抑素C与糖尿病肾病关系的研究[J].中国医药导刊,2011,13（7）：1109-1110.

相似文献/References:

[1].2007年糖尿病新进展学习班将举办[J].国际内分泌代谢杂志,2007,(04):226.
[2]李英,段惠军.Raf/MEK/ERK信号转导通路在糖尿病肾病发生发展中的作用[J].国际内分泌代谢杂志,2007,(04):264.
[3]张红 章向成 朱大龙.炎性反应与糖尿病肾病[J].国际内分泌代谢杂志,2015,(01):49.[doi:10.3760/cma.j.issn.1673-4157.2015.01.012]
　Zhang Hong*,Zhang Xiangcheng,Zhu Dalong..Role of inflammation in diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(03):49.[doi:10.3760/cma.j.issn.1673-4157.2015.01.012]
[4]邵滢,王秋月.Mir-217/Sirt1通路与糖尿病肾病[J].国际内分泌代谢杂志,2015,(02):124.[doi:10.3760/cma.j.issn.1673-4157.2015.02.014]
　Shao Ying,Wang Qiuyue..Mir-217 / Sirt1 pathway and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(03):124.[doi:10.3760/cma.j.issn.1673-4157.2015.02.014]
[5]王洁,何媛,于珮.糖尿病肾病的相关危险因素分析[J].国际内分泌代谢杂志,2015,(03):153.[doi:10.3760/cma.j.issn.1673-4157.2015.03.003]
　Wang Jie*,He Yuan,Yu Pei..Risk factors of diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(03):153.[doi:10.3760/cma.j.issn.1673-4157.2015.03.003]
[6]任慧雯,王秋月.Epac-Rap1与糖尿病肾病[J].国际内分泌代谢杂志,2015,(03):170.[doi:10.3760/cma.j.issn.1673-4157.2015.03.007]
　Ren Huiwen,Wang Qiuyue..Epac-Rap1 and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(03):170.[doi:10.3760/cma.j.issn.1673-4157.2015.03.007]
[7]邵滢,王秋月.MiRNA-150与糖尿病肾病[J].国际内分泌代谢杂志,2015,(03):173.[doi:10.3760/cma.j.issn.1673-4157.2015.03.008]
　Shao Ying,Wang Qiuyue..MiRNA-150 and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(03):173.[doi:10.3760/cma.j.issn.1673-4157.2015.03.008]
[8]陈堃,刘超,陈国芳,等.糖尿病肾病诊断标志物研究进展[J].国际内分泌代谢杂志,2015,(03):176.[doi:10.3760/cma.j.issn.1673-4157.2015.03.009]
　Chen Kun,Liu Chao,Chen Guofang,et al.Urinary biomarkers for diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(03):176.[doi:10.3760/cma.j.issn.1673-4157.2015.03.009]
[9]任慧雯,王秋月.Vasohibin-1与糖尿病肾病[J].国际内分泌代谢杂志,2015,(04):246.[doi:10.3760/cma.j.issn.1673-4157.2015.04.008]
　Ren Huiwen,Wang Qiuyue..Vasohibin-1 and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(03):246.[doi:10.3760/cma.j.issn.1673-4157.2015.04.008]
[10]安丽,王秋月.Visfatin与胰岛素抵抗及糖尿病肾病的发病机制[J].国际内分泌代谢杂志,2015,(04):248.[doi:10.3760/cma.j.issn.1673-4157.2015.04.009]
　An Li,Wang Qiuyue..Visfatin in the pathogenesis of insulin resistance and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(03):248.[doi:10.3760/cma.j.issn.1673-4157.2015.04.009]

更新日期/Last Update: 2014-05-20