[1]蔡芸莹,苏恒.青春期发育延迟的鉴别诊断进展[J].国际内分泌代谢杂志,2023,43(06):477-480.[doi:10.3760/cma.j.cn121383-20220825-08039]
 Cai Yunying,Su Heng..Update of differential diagnosis for delayed puberty[J].International Journal of Endocrinology and Metabolism,2023,43(06):477-480.[doi:10.3760/cma.j.cn121383-20220825-08039]
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青春期发育延迟的鉴别诊断进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年06期
页码:
477-480
栏目:
综述
出版日期:
2023-11-20

文章信息/Info

Title:
Update of differential diagnosis for delayed puberty
作者:
蔡芸莹苏恒
云南省第一人民医院内分泌科,昆明理工大学附属医院,昆明 650032
Author(s):
Cai Yunying Su Heng.
Department of Endocrinology, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China
关键词:
先天性低促性腺激素性性腺功能减退 体质性青春期发育延迟 抑制素B 动态试验
Keywords:
Congenital hypogonadotropic hypogonadism Constitutional delay of growth and puberty Inhibin B Dynamic test
DOI:
10.3760/cma.j.cn121383-20220825-08039
摘要:
体质性青春期发育延迟(constitutional delay of growth and puberty, CDGP)与先天性低促性腺激素性性腺功能减退(congenital hypogonadotropic hypogonadism, CHH)是两类导致青春期发育延迟的常见病因。两者在临床表现上具有较高的相似性,均表现为缺乏正常青春期启动、血液循环中促性腺激素及性激素水平低下。尽管CDGP为一过性、自限性的青春期发育延迟,而CHH是持久性的性腺功能减退,但两者在成年期前较难准确鉴别。近年来的研究显示,微小青春期对于早期诊断CHH是一个非常重要的时间窗口。此外,抑制素B水平以及Kisspeptin兴奋试验可能在两者的鉴别诊断上具有较大的应用价值。
Abstract:
Constitutional delay of growth and puberty(CDGP)and congenital hypogonadotropic Hypogonadism(CHH)are two common causes of delayed puberty. There is a high similarity between them in clinical manifestations: lack of normal puberty initiation, low levels of gonadotropin, and sex hormone. Although CDGP is a transient, self-limited form of delayed puberty while CHH is permanent, it isn't easy to accurately distinguish the two before adulthood. Recent studies have shown that mini-puberty is a critical time window for the early diagnosis of CHH. In addition, the inhibin B level and Kisspeptin stimulation test may have great application value in the differential diagnosis of the two.

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备注/Memo

备注/Memo:
基金项目:云南省卫生和计划生育委员会医学人才培养项目(L-201624); 云南省万人计划“名医”专项(YNWR-MY-2019-020)
通信作者:苏恒,Email: su_hen@ hotmail.com
更新日期/Last Update: 2023-12-30