[1]陈伟达,林小凤,温俊平.Kisspeptin调控生殖及性相关情感[J].国际内分泌代谢杂志,2023,43(06):473-476.[doi:10.3760/cma.j.cn121383-20230911-09024]
　Chen Weida,Lin Xiaofeng,Wen Junping..Kisspeptin regulates reproduction and sexual emotions[J].International Journal of Endocrinology and Metabolism,2023,43(06):473-476.[doi:10.3760/cma.j.cn121383-20230911-09024]
点击复制

Kisspeptin调控生殖及性相关情感()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年06期
页码:
473-476
栏目:
综述
出版日期:
2023-11-20

文章信息/Info

Title:
Kisspeptin regulates reproduction and sexual emotions
作者:
陈伟达; 林小凤; 温俊平
福建医科大学省立临床医学院,福建省立医院内分泌科,福建省立医院内分泌研究室,福州 350001
Author(s):
Chen Weida;  Lin Xiaofeng;  Wen Junping.
Shengli Clinical Medical College of Fujian Medical University, Department of Endocrinology, Laboratory of Endocrinology, Fujian Provincial Hospital, Fuzhou 350001, China
关键词:
Kisspeptin;  生殖;  情感
Keywords:
Kisspeptin;  Reproduction;  Emotion
DOI:
10.3760/cma.j.cn121383-20230911-09024
摘要:
Kiss1基因编码的Kisspeptin及其受体在哺乳动物体内分布广泛,目前Kisspeptin已被确认为哺乳动物生殖轴的重要调控因子,通过调控下丘脑促性腺激素释放激素的分泌,进而控制垂体黄体生成素和卵泡刺激素的分泌及性行为的调节。此外,Kisspeptin还参与情感方面的调节,包括恐惧、焦虑和认知等。生殖和情感关系密切,在临床中,生殖功能异常与情感障碍伴随的疾病十分常见,然而关于协调生殖与情感方面的研究还较少。目前的研究表明,Kisspeptin可能是介导生殖及情感协调的控制中心。本文将对Kisspeptin在生殖与情感功能两方面的调控作用进行综述,以期为防治因情感障碍导致的生殖疾病提供新的靶点和思路。
Abstract:
Kisspeptin and its receptor, encoded by the Kiss1 gene, are widely distributed in mammals. The role of Kisspeptin as a crucial regulator in the mammalian reproductive axis has been established. It exerts control over the secretion of luteinizing hormone(LH)and follicle-stimulating hormone(FSH)in the pituitary gland by modulating gonadotropin-releasing hormone(GnRH)secretion in the hypothalamus, while also playing a significant role in regulating sexual behavior. Moreover, Kisspeptin also plays a role in modulating emotional processes such as fear, anxiety, and cognition. Reproduction and emotion possess a complex and intricately relationship. In clinical practice, both reproductive dysfunction and emotional disorders are prevalent; however, there is limited research on the coordination between reproduction and emotional disorders. Current evidence suggests that Kisspeptins may serve as central regulators mediating reproductive-emotional coordination. This article reviews the regulatory effects of Kisspeptin on reproduction and emotional function, in order to provide new targets and ideas for the prevention and treatment of reproductive diseases caused by emotional disorders.

参考文献/References:

[1] McEvoy K,Payne JL,Osborne LM.Neuroactive steroids and perinatal depression:a review of recent literature [J].Curr Psychiatry Rep,2018,20(9):78.DOI:10.1007/s11920-018-0937-4.
[2] Stiernman L,Dubol M,Comasco E,et al.Emotion-induced brain activation across the menstrual cycle in individuals with premenstrual dysphoric disorder and associations to serum levels of progesterone-derived neurosteroids [J].Transl Psychiatry,2023,13(1):124.DOI:10.1038/s41398-023-02424-3.
[3] Fischer S,Ehlert U,Amiel Castro R.Hormones of the hypothalamic-pituitary-gonadal(HPG)axis in male depressive disorders:a systematic review and meta-analysis [J].Front Neuroendocrinol,2019,55:100792.DOI:10.1016/j.yfrne.2019.100792.
[4] Yeo SH,Kyle V,Morris PG,et al.Visualisation of Kiss1 neurone distribution using a Kiss1-CRE transgenic mouse [J].J Neuroendocrinol,2016,28(11):10.1111/jne.DOI:10.1111/jne.12435.
[5] Hrabovszky E,Molnár CS,Sipos MT,et al.Sexual dimorphism of Kisspeptin and neurokinin B immunoreactive neurons in the infundibular nucleus of aged men and women [J].Front Endocrinol(Lausanne),2011,2:80.DOI:10.3389/fendo.2011.00080.
[6] Topaloglu AK,Tello JA,Kotan LD,et al.Inactivating KISS1 mutation and hypogonadotropic hypogonadism [J].N Engl J Med,2012,366(7):629-635.DOI:10.1056/NEJMoa1111184.
[7] Teles MG,Bianco SD,Brito VN,et al.A GPR54-activating mutation in a patient with central precocious puberty [J].N Engl J Med,2008,358(7):709-715.DOI:10.1056/NEJMoa073443.
[8] De Bond JA,Li Q,Millar RP,et al.Kisspeptin signaling is required for the luteinizing hormone response in anestrous ewes following the introduction of males [J].PLoS One,2013,8(2):e57972.DOI:10.1371/journal.pone.0057972.
[9] Adekunbi DA,Li XF,Lass G,et al.Kisspeptin neurones in the posterodorsal medial amygdala modulate sexual partner preference and anxiety in male mice [J].J Neuroendocrinol,2018,30(3):e12572.DOI:10.1111/jne.12572.
[10] Pineda R,Plaisier F,Millar RP,et al.Amygdala Kisspeptin neurons:putative mediators of olfactory control of the gonadotropic axis [J].Neuroendocrinology,2017,104(3):223-238.DOI:10.1159/000445895.
[11] Bakker J,Pierman S,González-Martínez D.Effects of aromatase mutation(ArKO)on the sexual differentiation of Kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones [J].Horm Behav,2010,57(4-5):390-395.DOI:10.1016/j.yhbeh.2009.11.005.
[12] Asaba A,Osakada T,Touhara K,et al.Male mice ultrasonic vocalizations enhance female sexual approach and hypothalamic Kisspeptin neuron activity [J].Horm Behav,2017,94:53-60.DOI:10.1016/j.yhbeh.2017.06.006.
[13] Capela D,Dombret C,Poissenot K,et al.Adult male mice exposure to nonylphenol alters courtship vocalizations and mating [J].Sci Rep,2018,8(1):2988.DOI:10.1038/s41598-018-21245-9.
[14] Hellier V,Brock O,Candlish M,et al.Female sexual behavior in mice is controlled by Kisspeptin neurons [J].Nat Commun,2018,9(1):400.DOI:10.1038/s41467-017-02797-2.
[15] Hellier V,Brock O,Bakker J.The role of Kisspeptin in sexual behavior [J].Semin Reprod Med,2019,37(2):84-92.DOI:10.1055/s-0039-3400992.
[16] Gresham R,Li S,Adekunbi DA,et al.Kisspeptin in the medial amygdala and sexual behavior in male rats [J].Neurosci Lett,2016,627:13-17.DOI:10.1016/j.neulet.2016.05.042.
[17] Szeliga A,Czyzyk A,Podfigurna A,et al.The role of Kisspeptin/neurokinin B/dynorphin neurons in pathomechanism of vasomotor symptoms in postmenopausal women:from physiology to potential therapeutic applications [J].Gynecol Endocrinol,2018,34(11):913-919.DOI:10.1080/09513590.2018.1480711.
[18] Padilla SL,Johnson CW,Barker FD,et al.A neural circuit underlying the generation of hot flushes [J].Cell Rep,2018,24(2):271-277.DOI:10.1016/j.celrep.2018.06.037.
[19] Lederman S,Ottery FD,Cano A,et al.Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause(SKYLIGHT 1):a phase 3 randomised controlled study [J].Lancet,2023,401(10382):1091-1102.DOI:10.1016/s0140-6736(23)00085-5.
[20] Comninos AN,Demetriou L,Wall MB,et al.Modulations of human resting brain connectivity by Kisspeptin enhance sexual and emotional functions [J].JCI Insight,2018,3(20):e121958.DOI:10.1172/jci.insight.121958.
[21] Delmas S,Porteous R,Bergin DH,et al.Altered aspects of anxiety-related behavior in Kisspeptin receptor-deleted male mice [J].Sci Rep,2018,8(1):2794.DOI:10.1038/s41598-018-21042-4.

相似文献/References:

[1]张齐,郑楷,钟秀宏,等.瘦素与男性不育症的关系[J].国际内分泌代谢杂志,2016,36(04):281.[doi:10.3760/cma.j.issn.1673-4157.2016.04.17]
　Zhang Qi,Zheng Kai,Zhong Xiuhong,et al.Relationship between leptin and male infertility[J].International Journal of Endocrinology and Metabolism,2016,36(06):281.[doi:10.3760/cma.j.issn.1673-4157.2016.04.17]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(82070878,82370786)
通信作者:温俊平,Email:junpingwen@163.com
更新日期/Last Update: 2023-12-30