[1]王倩,刘亚平.卵泡刺激素对骨代谢作用的研究进展[J].国际内分泌代谢杂志,2023,43(04):305-308,316.[doi:10.3760/cma.j.cn121383-20220307-03016]
 Wang Qian,Liu Yaping.Research progress of follicle stimulating hormone on bone metabolism[J].International Journal of Endocrinology and Metabolism,2023,43(04):305-308,316.[doi:10.3760/cma.j.cn121383-20220307-03016]
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卵泡刺激素对骨代谢作用的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年04期
页码:
305-308,316
栏目:
综述
出版日期:
2023-07-20

文章信息/Info

Title:
Research progress of follicle stimulating hormone on bone metabolism
作者:
王倩1刘亚平2
1济宁医学院临床医学院,济宁 272000; 2济宁市第一人民医院内分泌科,济宁 272000
Author(s):
Wang Qian1 Liu Yaping2
1Clinical Medical College,Jining Medical University, Jining 272000, China; 2Depatment of Endocrinology and Metabolism, Jining NO.1 People's Hospital, Jining 272000, China
关键词:
卵泡刺激素 骨质疏松 骨重建 破骨细胞 成骨细胞
Keywords:
Follicle stimulating hormone Osteoporosis Bone remodeling Osteoclast Osteoblast
DOI:
10.3760/cma.j.cn121383-20220307-03016
摘要:
卵泡刺激素(follicle stimulating hormone,FSH)是由垂体嗜碱性粒细胞合成的一种促性腺激素,与FSH受体(receptor of FSH,FSHR)结合,在人类和哺乳动物生殖功能中起着不可或缺的作用。以往将绝经后骨质疏松(postmenopausal osteoporosis,PMOP)完全归因于雌激素水平的显著下降,但在围绝经期两种成熟的性激素特点是雌二醇骤然下降,FSH显著升高。增高的FSH与骨密度的降低有关,该过程独立于雌激素之外。研究发现FSHR在生殖系统以外的不同器官和组织中也有表达,如骨组织。FSH-FSHR可能成为骨代谢性疾病治疗的靶点,本文就FSH影响骨代谢的作用及相关机制进行综述。
Abstract:
Follicle stimulating hormone(FSH)is a gonadotropin synthesized by pituitary basophils. It binds to FSH receptor(FSHR)and plays an indispensable role in the reproductive function of human and mammals. In the past, we attributed postmenopausal osteoporosis(PMOP)to a significant decrease in estrogen levels, but the two mature sex hormones during peri-menopause were characterized by a sudden decrease in estradiol and a significant increase in FSH. Increased FSH is associated with decreased bone mineral density, a process independent of estrogen.It has been found that FSHR is also expressed in different organs and tissues outside the reproductive system, such as bone tissue. FSH-FSHR may be a therapeutic target for bone metabolic diseases. This article reviews the effect of FSH on bone metabolism and its related mechanism.

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备注/Memo:
通信作者:刘亚平,Email:409972352@163.com
更新日期/Last Update: 2023-08-15