[1]孔晶,王鸥,邢小平.狄诺塞麦治疗代谢性骨病的研究进展[J].国际内分泌代谢杂志,2016,36(05):334-338,341.[doi:10.3760/cma.j.issn.1673-4157.2016.05.13]
 Kong Jing,Wang Ou,Xing Xiaoping.Update on denosumab treatment in metabolic bone diseases[J].International Journal of Endocrinology and Metabolism,2016,36(05):334-338,341.[doi:10.3760/cma.j.issn.1673-4157.2016.05.13]
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狄诺塞麦治疗代谢性骨病的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年05期
页码:
334-338,341
栏目:
综述
出版日期:
2016-09-20

文章信息/Info

Title:
Update on denosumab treatment in metabolic bone diseases
作者:
孔晶王鸥邢小平
100730 北京,中国医学科学院,北京协和医学院,北京协和医院内分泌科,卫生及计划生育委员会内分 泌重点实验室
Author(s):
Kong Jing Wang Ou Xing Xiaoping
Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China
关键词:
核因子-κB受体活化因子配体 狄诺塞麦 骨质疏松 代谢性骨病
Keywords:
Receptor activator of nuclear factor-kappa B ligand Denosumab Osteoporosis Metabolic bone diseases
DOI:
10.3760/cma.j.issn.1673-4157.2016.05.13
摘要:
狄诺塞麦(Denosumab)是人抗核因子-κB受体活化因子配体(RANKL)的IgG2型单克隆抗体。它是治疗 骨质疏松的第一种单克隆抗体药物,多个临床试验已证实,其可以抑制骨转换、提高骨密度以及降低骨折风险。 目前也有少量研究发现,其对畸形性骨炎、骨纤维异常增殖症、成骨不全等其他代谢性骨病有较良好的疗效。
Abstract:
Denosumab is a human IgG2 monoclonal antibody to the receptor activator of nuclear factor-κB ligand(RANKL). It is the first monoclonal antibody agent to treat osteoporosis. Kinds of clinical trials showed that denosumab could suppress bone turnover, increase bone mineral density(BMD)and reduce the risk of fracture. Recently, denosumab has been found to be effective in other metabolic bone diseases, such as Paget's disease of bone, fibrous dysplasia and osteogenesis imperfecta.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81270873); 国家临床重点专科课题(WBYZ 2011-873) 通信作者:邢小平,Email: xingxp2006@126.com
更新日期/Last Update: 2016-11-20