[1]黄庆先,胡文超,何兰杰.血清asprosin与糖尿病视网膜病变的 相关性研究[J].国际内分泌代谢杂志,2020,40(06):372-375.[doi:10.3760/cma.j.cn121383-20200311-03027]
　Huang Qingxian,Hu Wenchao,He Lanjie.Association of serum asprosin concentrations with diabetic retinopathy[J].International Journal of Endocrinology and Metabolism,2020,40(06):372-375.[doi:10.3760/cma.j.cn121383-20200311-03027]
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血清asprosin与糖尿病视网膜病变的 相关性研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
40
期数:
2020年06期
页码:
372-375
栏目:
论著
出版日期:
2020-11-20

文章信息/Info

Title:
Association of serum asprosin concentrations with diabetic retinopathy
作者:
黄庆先; 胡文超; 何兰杰
山东大学齐鲁医院青岛院区内分泌科 266035
Author(s):
Huang Qingxian;  Hu Wenchao;  He Lanjie
Department of Endocrinology, Qilu Hospital(Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266035, China
关键词:
Asprosin;  糖尿病视网膜病变;  糖尿病
Keywords:
Asprosin;  Diabetic retinopathy;  Diabetes mellitus
DOI:
10.3760/cma.j.cn121383-20200311-03027
文献标志码:
A
摘要:
目的 探讨糖尿病视网膜病变患者血清asprosin水平与糖尿病视网膜病变的相关性。方法 纳入 2018年10月—2019年4月在山东大学齐鲁医院内分泌科就诊的120例2型糖尿病患者(2型糖尿病组)和34名健康对照者(对照组)。糖尿病患者根据眼底检查结果分为无视网膜病变的糖尿病组(52例)、非增殖性糖尿病视网膜病变(NPDR)组(42例)和增殖性糖尿病视网膜病变(PDR)组(26例),测量身高、体重、血压。空腹8 h后抽取静脉血,检测血脂、糖化血红蛋白,酶联免疫吸附法检测血清asprosin水平。结果 2型糖尿病组血清asprosin高于健康对照组,PDR组血清asprosin高于其他两组糖尿病患者,而NPDR组血清asprosin也明显高于无视网膜病变的糖尿病组(F=35.526,P=0.000)。Logistic回归分析显示,血清asprosin是糖尿病视网膜病变发病的独立危险因素(OR=1.268,95% CI:1.121～1.435,P=0.000)。结论 糖尿病视网膜病变患者的血清asprosin升高,且asprosin升高是糖尿病视网膜病变的危险因素。
Abstract:
Objective To determine the association between serum asprosin levels with diabetic retinopathy.Methods A total of 120 type 2 diabetes(T2DM)patients(T2DM group)who were enrolled from the inpatients of the Department of Endocrinology, Qilu Hospital of Shandong University from October, 2018 to April, 2019 and 34 control subjects(control group)were enrolled. Diabetic patients were then divided into T2DM patients without diabetic retinopathy group(n=52), non-proliferative diabetic retinopathy(NPDR)group(n=42), and proliferative diabetic retinopathy(PDR)group(n=26). Height, weight, and blood pressure were measured. Venous blood were abstracted from all subjects after fasting for 8 hours. Then serum lipid and glycosylated hemoglobin were assessed. Serum asprosin levels were assessed using enzyme linked immunosorbent assay.Results Serum asprosin level was significantly higher in the diabetic groups than that in control group. Serum asprosin level was significantly increased in PDR group compared with the other two T2DM groups. In addition, compared with diabetic patients without diabetic retinopathy group, serum asprosin level was significantly increased in NPDR group(F=35.526, P=0.000). Logistic regression analysis demonstrated that serum asprosin was an independent risk factor of diabetic retinopathy(OR=1.268, 95% CI:1.121-1.435, P=0.000).Conclusion Serum asprosin level is elevated in diabetic retinopathy patients. Serum asprosin is correlated with diabetic retinopathy.

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备注/Memo

备注/Memo:
通信作者:胡文超,Email:tjmuhwc@126.com
更新日期/Last Update: 2020-11-20