[1]张玲,洪洁.热量限制对肥胖患者心血管危险因素的影响[J].国际内分泌代谢杂志,2020,40(05):310-314.[doi:10.3760/cma.j.cn121383-20191224-12071]
 Zhang Ling,Hong Jie.Effects of caloric restriction on cardiovascular risk in obese patients[J].International Journal of Endocrinology and Metabolism,2020,40(05):310-314.[doi:10.3760/cma.j.cn121383-20191224-12071]
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热量限制对肥胖患者心血管危险因素的影响()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
40
期数:
2020年05期
页码:
310-314
栏目:
综述
出版日期:
2020-09-20

文章信息/Info

Title:
Effects of caloric restriction on cardiovascular risk in obese patients
作者:
张玲洪洁
上海交通大学医学院附属瑞金医院内分泌代谢病科,上海市内分泌代谢病临床医学中心,上海市内分泌代谢病研究所 200025
Author(s):
Zhang Ling Hong Jie
Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China
关键词:
热量限制 肥胖 心血管危险因素
Keywords:
Caloric restriction Obesity Cardiovascular risk
DOI:
10.3760/cma.j.cn121383-20191224-12071
文献标志码:
A
摘要:
肥胖是发生心血管事件的重要危险因素,而心脑血管疾病占全球全因死亡率首位。近年来热量限制对心血管危险因素如血压、心率、脉搏波传导速度、血脂及炎性反应细胞因子的改善作用已被普遍认可,其主要机制包括改善胰岛素抵抗、调节细胞因子水平、影响AMP活化蛋白激酶及沉默信息调节因子2相关酶类活性、调节肠道菌群和逆转血管重塑等。
Abstract:
Obesity is an important risk factor for cardiovascular events, and cardiovascular and cerebrovascular diseases account for the highest all-cause mortality worldwide. Recently, the benefits of caloric restriction on cardiovascular risk factors such as blood pressure, heart rate, pulse wave velocity, blood lipid and inflammatory cytokines have repeatedly been shown. The main mechanisms include improvement in insulin sensitivity, regulation of cytokine, increased activity of AMP-activated protein kinase and silent mating type information regulation 2 homolog, adjustment of gut microbiota and reversion of vascular remodeling.

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备注/Memo

备注/Memo:
基金项目:国家重点研发计划项目(2018YFC1313800); 国家自然科学基金(81870582); 上海市优秀学术带头人计划(19XD1403200) 通信作者:洪洁,Email:hongjie@medmail.com.cn
更新日期/Last Update: 2020-09-20