[1]刘彤,杨亚娟.高尿酸血症与心房颤动的关系[J].国际内分泌代谢杂志,2016,36(04):220-222.[doi:10.3760/cma.j.issn.1673-4157.2016.04.02]
 Liu Tong,Yang Yajuan.Relationship between hyperuricemia and atrial fibrillation[J].International Journal of Endocrinology and Metabolism,2016,36(04):220-222.[doi:10.3760/cma.j.issn.1673-4157.2016.04.02]
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高尿酸血症与心房颤动的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年04期
页码:
220-222
栏目:
高尿酸血症/痛风相关代谢性疾病专栏
出版日期:
2016-07-20

文章信息/Info

Title:
Relationship between hyperuricemia and atrial fibrillation
作者:
刘彤杨亚娟
300211 天津市心血管病离子与分子机能重点实验室,天津医科大学第二医院心脏科,天津心脏病学研究所
Author(s):
Liu Tong Yang Yajuan
Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China
关键词:
高尿酸血症 尿酸 黄嘌呤氧化酶 心房颤动
Keywords:
Hyperuricemia Uric acid Xanthine oxidase Atrial fibrillation
DOI:
10.3760/cma.j.issn.1673-4157.2016.04.02
摘要:
心房颤动是临床上最常见的持续性心律失常,可能导致心力衰竭、血栓栓塞等并发症。心房颤动的发生、发展可能与心房重构、炎性反应及氧化应激有关。人体内血尿酸不仅与心房氧化应激程度密切相关,还与炎性标志物水平相关,因此血尿酸水平与多种心血管疾病密切相关。近年来,越来越多的研究表明,血尿酸水平升高和心房颤动的发生风险密切相关,其可能机制一方面是高尿酸血症可以使高血压、肾功能衰竭等疾病发生风险增加,而后者是心房颤动发生的重要危险因素; 另一方面氧化应激和炎性反应参与了心房颤动的发生,这可能是高尿酸血症和心房颤动联系的中间环节。
Abstract:
As the most common sustained arrhythmia, atrial fibrillation(AF)can lead to complications such as heart failure, thromboembolism. Atrial electrical and structural remodeling, inflammatory reaction and oxidative stress may play important roles in the occurrence and progress of AF. Uric acid is closely related to not only the degree of oxidative stress, but also the level of inflammatory markers, which contributes to the relationship between uric acid and cardiovascular diseases. In recent years, more and more studies confirmed that hyperuricemia can increase the risk of AF. On the one hand, elevated level of serum uric acid increases the risk of hypertension and renal failure, which are the risk factors of AF. On the other hand, oxidative stress and inflammatory reaction process are involved in the occurrence of AF, which may be a hub for the relationship between hyperuricemia and AF.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81270245, 81570298) 通信作者:刘彤,Email:liutongdoc@126.com
更新日期/Last Update: 2016-09-20