[1]林天烨,方文军.肠道菌群与代谢性疾病的关系[J].国际内分泌代谢杂志,2014,(04):277-280.[doi:10.3760/cma.j.issn.1673-4157.2014.04.018]
　Lin Tianye*,Fang Wenjun..Relationship between microbiota and metabolic diseases[J].International Journal of Endocrinology and Metabolism,2014,(04):277-280.[doi:10.3760/cma.j.issn.1673-4157.2014.04.018]
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肠道菌群与代谢性疾病的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年04期
页码:
277-280
栏目:
综述
出版日期:
2014-08-31

文章信息/Info

Title:
Relationship between microbiota and metabolic diseases
作者:
林天烨; 方文军
作者单位：200092　上海交通大学新华临床医学院（林天烨）；上海交通大学医学院附属新华医院内分泌科（方文军） 　　
Author(s):
Lin Tianye*; Fang Wenjun.
*Shanghai Jiaotong University School of Xinhua Clinical Medicine，Shanghai 200092，China Corresponding author：Fang Wenjun，Email：fangwenjun99@sina.com
关键词:
代谢性疾病; 肠道菌群; 内毒素
Keywords:
Metabolic disorders; Gut microbiota; Endotoxin
DOI:
10.3760/cma.j.issn.1673-4157.2014.04.018
摘要:
近来，肠道菌群在代谢性疾病中的作用逐渐受到重视。肠道菌群可影响机体能量摄取,代谢综合征患者肠道菌群种类与正常个体存在差异，由此引发的内毒素血症和胰岛素靶器官的慢性炎性反应影响机体代谢。一些调理肠道菌群的治疗措施，如抗生素、益生菌和益生元等可以调节胃肠激素的分泌，抑制食欲，减弱慢性炎性反应，增加靶器官的胰岛素敏感性。干预肠道菌群有望成为未来代谢性疾病的辅助治疗方法之一。
Abstract:
Recently，the gut microbiota is increasingly thought to play an important role in the development of metabolic disorders. Gut microbiota may manipulate energy harvest，the gut microbiota in patients with metabolic diseases is different from that in healthy individuals. The abnormal gut microbiota induced endotoxemia and chronic inflammation of target organs initiate the metabolic disorders. Several strategies（antibiotics， probiotics and prebiotics）focusing on modulation of the gut microbiota can be used to modulate the secretion of gastrointestinal hormones and therefore regulate appetite，improve the chronic inflammation，and promote insulin sensitivity in insulin target organs. Modulation of gut microbiota may become an adjuvant therapy for metabolic disease in future.

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备注/Memo

备注/Memo:
通信作者：方文军，Email:fangwenjun99@sina.com
更新日期/Last Update: 2014-07-20