[1]刘丹,徐书杭,陈国芳,等.甲状腺激素对胰岛β细胞功能的调控[J].国际内分泌代谢杂志,2014,(01):18-21.[doi:10.3760/cma.j.issn.1673-4157.2014.01.005]
 Liu Dan*,Xu Shuhang,Chen Guofang,et al.Regulation of thyroid hormone on islet β cells[J].International Journal of Endocrinology and Metabolism,2014,(01):18-21.[doi:10.3760/cma.j.issn.1673-4157.2014.01.005]
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甲状腺激素对胰岛β细胞功能的调控()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年01期
页码:
18-21
栏目:
综述
出版日期:
2014-02-28

文章信息/Info

Title:
Regulation of thyroid hormone on islet β cells
作者:
刘丹徐书杭陈国芳刘超
210000 南京中医药大学(刘丹);210028 南京中医药大学附属中西医结合医院内分泌代谢病院区(徐书杭,陈国芳,刘超)   
Author(s):
Liu Dan*Xu ShuhangChen GuofangLiu Chao.
*Nanjing University of Traditional Chinese Medicine,Nanjing 210000,China Corresponding author:Liu Chao,Email:liuchao@nfmcn.com
关键词:
甲状腺激素胰岛β细胞核受体促甲状腺激素释放激素
Keywords:
Thyroid hormoneIslet β cellsNuclear receptorsThyrotropin releasing hormone
DOI:
10.3760/cma.j.issn.1673-4157.2014.01.005
摘要:
甲状腺功能异常包括甲状腺功能亢进症和甲状腺功能减退症,常合并糖调节受损。传统观点认为,甲状腺功能亢进症与胰岛素抵抗相关,但近年的研究表明,甲状腺功能减退症亦可导致胰岛素敏感性的降低。不仅如此,甲状腺激素对胰岛β细胞的功能尚具有调控作用,适当浓度的甲状腺激素可抑制胰岛β细胞凋亡,而过量的甲状腺激素则可能造成胰岛β功能损伤,其机制可能涉及核受体信号通路、促甲状腺激素释放激素等。
Abstract:
Thyroid dysfunction,including hyperthyroidism and hypothyroidism, is often associated with impaired glucose regulation.Hyperthyroidism was thought to be mainly related with insulin resistance, though recent reports showed that hypothyroidism could decrease insulin sensitivity.Furthermore,thyroid hormone has also been found to regulate the function of islet β cells.An appropriate level of thyroid hormone is a survival factor for islet β cells undergoing apoptosis,while excessive thyroid hormone may cause the dysfunction of islet β cells.Thyroid hormone can influence β cells by different pathways including binding to nuclear receptors,thyrotropin releasing hormone,etc.

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备注/Memo

备注/Memo:
通信作者:刘超,Email:liuchao@nfmcn.com
更新日期/Last Update: 2014-01-20