[1]许瀚元 朱惠娟 龚凤英.白脂素:一种新型的脂肪细胞因子[J].国际内分泌代谢杂志,2018,38(06):401-404.[doi:10.3760/cma.j.issn.1673-4157.2018.06.010]
　Xu Hanyuan,Zhu Huijuan,Gong Fengying.Asprosin: a newly identified adipokine[J].International Journal of Endocrinology and Metabolism,2018,38(06):401-404.[doi:10.3760/cma.j.issn.1673-4157.2018.06.010]
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白脂素:一种新型的脂肪细胞因子()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年06期
页码:
401-404
栏目:
综述
出版日期:
2018-11-20

文章信息/Info

Title:
Asprosin: a newly identified adipokine
作者:
许瀚元 朱惠娟 龚凤英
作者单位:100730 北京,中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室,协和转化医学中心
Author(s):
Xu Hanyuan;  Zhu Huijuan;  Gong Fengying
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, The Translational Medicine Center of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, C
关键词:
白脂素;  脂肪细胞因子;  糖代谢;  AgRP神经元;  POMC神经元
Keywords:
Asprosin;  Adipokines;  Glucose metabolism;  AgRP neurons;  POMC neurons
DOI:
10.3760/cma.j.issn.1673-4157.2018.06.010
摘要:
白脂素(Asprosin)是2016年由Romere等研究发现的一种新型脂肪细胞因子。其主要由白色脂肪细胞产生并分泌,它一方面能够与肝细胞表面的受体结合,刺激肝细胞葡萄糖输出,直接使血糖升高; 另一方面,能透过血-脑屏障,激活下丘脑中枢摄食相关的刺鼠基因相关蛋白(AgRP)神经元活性,并抑制厌食相关阿片-促黑素细胞皮质素原(POMC)神经元活性,促进摄食,间接发挥升血糖作用。此外,血清白脂素水平在胰岛素抵抗者与小鼠中均显著升高; 而以白脂素特异性抗体中和,使小鼠血清白脂素水平下降,则能够显著改善小鼠糖耐量,增加胰岛素的敏感性。因此,白脂素作为一种新型的细胞因子,在糖代谢调节中发挥着重要作用,有望在未来成为治疗2型糖尿病的新靶点。
Abstract:
Asprosin, which was identified by Romere et al in 2016, is a novel adipokine mainly secreted by white adipose tissue. On one hand, it binds to the surface receptors of hepatocyte to stimulate hepatic glucose release, therefore directly increases plasma glucose levels.On the other hand, it crosses through the blood-brain barrier, activating hypothalamic orexigenic agouti gene-related protein(AgRP), neurons as well as suppressing anorexigenic pro-opiomelanocortin(POMC)neurons, thus indirectly increasing plasma glucose levels. Moreover, it has been reported that serum asprosin level was significantly increased in patients and mouse with insulin resistance. Whereas insulin resistance of mouse was remarkably improved after serum asprosin is neutralized by asprosin-specific antibody. Therefore, asprosin, as a newly identified adipokine and an appetite stimulator, plays an important role in the regulation of glucose metabolism and may bring potential opportunity for the treatment of type 2 diabetes in the future.

参考文献/References:


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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(30540036,30771026,81370898); 北京市自然科学基金(7082079,7182130); 人社部留学人员科技活动项目择优资助经费(启动类); 国家临床重点专科建设项目单位(WBYZ2011-873); 协和中青年基金(2013-020)
Fund program:National Natural Science Foundation of China(30540036, 30771026, 81370898); Natural Science
更新日期/Last Update: 2018-12-30