[1]刘伟伟 陶枫 高建东.多巴胺与肥胖的关系[J].国际内分泌代谢杂志,2018,38(02):89-92.[doi:10.3760/cma.j.issn.1673-4157.2018.02.004]
 Liu Weiwei*,Tao Feng,Gao Jiandong..Relationship between dopamine and obesity[J].International Journal of Endocrinology and Metabolism,2018,38(02):89-92.[doi:10.3760/cma.j.issn.1673-4157.2018.02.004]
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多巴胺与肥胖的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年02期
页码:
89-92
栏目:
综述
出版日期:
2018-03-20

文章信息/Info

Title:
Relationship between dopamine and obesity
作者:
刘伟伟 陶枫 高建东
201203 上海中医药大学附属曙光医院肾病科,上海中医药大学中医肾病研究所,肝肾疾病病证教育部重点实验室(上海中医药大学),上海市中医临床重点实验室(刘伟伟、高建东),上海中医药大学附属曙光医院内分泌科; 上海市科委中医临床重点实验室(陶枫)
Author(s):
Liu Weiwei* Tao Feng Gao Jiandong.
*Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Traditional Chinese Medicine Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine; Key Laboratory of Liv
关键词:
多巴胺 肥胖 大脑奖赏系统 治疗
Keywords:
Dopamine Obesity Brain reward system Treatment
DOI:
10.3760/cma.j.issn.1673-4157.2018.02.004
摘要:
环境、遗传等因素可导致肥胖,其中多巴胺与肥胖的关系成为研究热点。可口美味的食物通过激活大脑奖赏系统,使多巴胺释放增多,机体获得满足和愉悦感,从而摄食成瘾,导致肥胖; 多巴胺D2受体不足,机体出现奖赏不足综合征; 为补偿机体降低的愉悦感和满足感代偿性过度摄食,从而发生肥胖; 此外,多巴胺功能障碍还可减少机体活动。探究多巴胺与肥胖的关系,有利于进一步阐释肥胖的发病机制,为肥胖的治疗提供新的思路和手段。
Abstract:
Environmental, genetic and other factors can lead to obesity,in which the relationship between dopamine and obesity becomes a hot topic. Palatable food can activate the brain reward system and increase dopamine release that makes the body get satisfaction and pleasure, and feeding addiction leads to obesity; thus the deficiency of dopamine D2 receptor causes reward deficiency syndrome. Excessive feeding to compensate for the reduced sense of pleasure and satisfaction,leads to obesity; in addition, dopamine dysfunction can also reduce body activity.Exploring the relationship between dopamine and obesity, is beneficial to further explain the pathogenesis of obesity and to provide new ideas and methods for the treatment of obesity.

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备注/Memo

备注/Memo:
基金项目:上海中医药大学研究生“创新能力培养”专项科研项目(B201717)
通信作者:高建东,Email:gaojiandong@hotmail.com
更新日期/Last Update: 1900-01-01