[1]杨曦,刘玉洁,马慧娟.C1q/肿瘤坏死因子相关蛋白12与糖代谢[J].国际内分泌代谢杂志,2016,36(03):195-197,201.[doi:10.3760/cma.j.issn.1673-4157.2016.03.13]
 Yang Xi*,Liu Yujie,Ma Huijuan..C1q/tumor necrosis factor-related protein 12 and glucose metabolism[J].International Journal of Endocrinology and Metabolism,2016,36(03):195-197,201.[doi:10.3760/cma.j.issn.1673-4157.2016.03.13]
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C1q/肿瘤坏死因子相关蛋白12与糖代谢()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年03期
页码:
195-197,201
栏目:
综述
出版日期:
2016-05-20

文章信息/Info

Title:
C1q/tumor necrosis factor-related protein 12 and glucose metabolism
作者:
杨曦刘玉洁马慧娟
050017 石家庄,河北医科大学研究生学院(杨曦,刘玉洁); 内科学教研室(马慧娟); 050051 石家庄,河北省人民医院内分泌科,河北省老年医学重点实验室(马慧娟)
Author(s):
Yang Xi* Liu Yujie Ma Huijuan.
*Graduate Institute of Hebei Medical University, Shijiazhuang 050017, China
关键词:
CTRP12 肥胖 脂肪组织
Keywords:
CTRP12 Obesity Fat tissue
DOI:
10.3760/cma.j.issn.1673-4157.2016.03.13
摘要:
C1q/肿瘤坏死因子相关蛋白(CTRP)12是一种新型脂肪因子,属于CTRP超家族成员。其主要在脂肪组织表达及分泌,通过增强脂肪组织和肝脏中胰岛素信号,改善胰岛素抵抗,增加胰岛素敏感性。同时CTRP12还能降低脂肪组织炎性反应。CTRP12通过胰岛素依赖和非依赖的方式发挥作用,有望成为治疗胰岛素抵抗和2型糖尿病的新靶点。
Abstract:
As a novel adipokine, C1q/tumor necrosis factor-related protein(CTRP)12 belongs to the CTRP family, which is abundantly expressed in fat tissues. CTRP12 ameliorates insulin resistance and improves insulin sensitivity by enhancing insulin signaling in the liver and adipose tissue. CTRP12 also can attenuate inflammation in fat tissue. CTRP12 acts in insulin-dependent and independent manners, and represents a new target for the treatment of insulin resistance and type 2 diabetes.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81200638)
更新日期/Last Update: 2016-05-20