[1]张红 章向成 朱大龙.炎性反应与糖尿病肾病[J].国际内分泌代谢杂志,2015,(01):49-52.[doi:10.3760/cma.j.issn.1673-4157.2015.01.012]
 Zhang Hong*,Zhang Xiangcheng,Zhu Dalong..Role of inflammation in diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(01):49-52.[doi:10.3760/cma.j.issn.1673-4157.2015.01.012]
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炎性反应与糖尿病肾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年01
页码:
49-52
栏目:
综述
出版日期:
2015-01-20

文章信息/Info

Title:
Role of inflammation in diabetic nephropathy
作者:
张红 章向成 朱大龙
223300 南京医科大学附属淮安第一医院内分泌科(张红,章向成);210008南京大学医学院附属鼓楼医院内分泌科(朱大龙)
Author(s):
Zhang Hong*Zhang Xiangcheng Zhu Dalong.
*Department of Endocrinology, Huaian First Peoples Hospital, Nanjing Medical University, Huaian 223300, China
关键词:
糖尿病肾病炎症治疗
Keywords:
Diabetic nephropathyInflammationTreatment
DOI:
10.3760/cma.j.issn.1673-4157.2015.01.012
摘要:
传统观点认为,代谢异常及血流动力学障碍是糖尿病肾病的主要原因。近来研究认为,天然免疫介导的慢性、低水平炎性反应在糖尿病肾病的发生及发展中起核心作用。细胞黏附分子、生长因子、趋化因子和促炎细胞因子在糖尿病患者肾组织的表达增多,且血清和尿中的细胞因子和黏附分子的水平与白蛋白尿相关。研究发现一些抗炎药物在糖尿病动物模型中有肾保护作用。因此深入了解糖尿病肾病的发病机制,并转化到临床开发相应的治疗策略,将可延缓甚至阻止糖尿病肾病的发生和发展。
Abstract:
Traditional opinions suggest that metabolic disorder and hemodynamic alterations are the critical causes of diabetic nephropathy.However, recent studies indicate that a chronic low-grade inflammation and an activation of the immune system are involved in development and progression of diabetic nephropathy. Expression of cell adhesion molecules, growth factors, chemokines and pro-inflammatory cytokines are increased in renal tissues of diabetic patients, and serum,urinary cytokines and cell adhesion molecules correlate with albuminuria.Several kinds of drugs that have anti-inflammatory actions show renal protective effects in diabetic animals.Therefore, investigating the role of inflammation in the development of diabetic nephropathy and translating it into new therapeutic strategies may be helpful in the prevention and treatment of diabetic nephropathy.

参考文献/References:

[1]Reutens AT, Atkins RC. Epidemiology of diabetic nephropathy[J]. Contrib Nephrol,2011, 170: 1-7.
[2]García-García PM, Getino-Melián MA, Domínguez-Pimentel V,et al.Inflammation in diabetic kidney disease[J].World J Diabetes,2014, 5(4): 431-443.
[3]Navarro-González JF, Mora-Fernández C, Muros de Fuentes M, et al. Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy[J].Nat Rev Nephrol, 2011,7(6):327-340.
[4]King GL.The role of inflammatory cytokines in diabetes and its complications[J].J Periodontol,2008,79(8 Suppl): 1527-1534.?
[5]Navarro-González JF, Mora-Fernández C. The role of inflammatory cytokines in diabetic nephropathy[J].J Am Soc Nephrol, 2008,19(3): 433-442.?
[6]Lim AK, Tesch GH. Inflammation in diabetic nephropathy[J]. Mediators Inflamm,2012,2012: 146-154.?
[7]Wu CC, Sytwu HK, Lin YF. Cytokines in diabetic nephropathy[J]. Adv Clin Chem,2012,56: 55-74
[8]Schmid H, Boucherot A, Yasuda Y, et al. Modular activation of nuclear factor-κB transcriptional programs in human diabetic nephropathy[J].Diabetes,2006,55(11): 2993-3003.
[9]Nguyen D, Ping F, Mu W, et al. Macrophage accumulation in human progressive diabetic nephropathy[J].Nephrology(Carlton),2006, 11(3): 226-231.?
[10]Tesch GH. Macrophages and diabetic nephropathy[J].Semin Nephrol, 2010, 30(3): 290-301.
[11]Lee FT, Cao Z, Long DM, et al. Interactions between angiotensin Ⅱ and NF- κB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy[J]. J Am Soc Nephrol,2004, 15(8): 2139-2151.
[12]Han SY, Kim CH, Kim HS, et al. Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats[J]. J Am Soc Nephrol,2006,17(5): 1362-1372.
[13]Davis TM, Ting R, Best JD, et al. Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study[J]. Diabetologia, 2011, 54(2): 280-290.?
[14]Kouroumichakis I, Papanas N, Zarogoulidis P, et al. Fibrates: therapeutic potential for diabetic nephropathy [J].Eur J Intern Med, 2012, 23(4): 309-316.?
[15]Matsushita Y, Ogawa D, Wada J, et al. Activation of peroxisome proliferator activated receptor delta inhibits streptozotocin induced diabetic nephropathy through anti-inflammatory mechanisms in mice[J].Diabetes,2011,60(3): 960-968.
[16]Gu L, Ni Z, Qian J, et al. Pravastatin inhibits carboxymethyllysine-induced monocyte chemoattractant protein 1 expression in podocytes via prevention of signalling events[J]. Nephron Exp Nephrol,2007,106(1): e1-e10.?
[17]Nakamura T, Sato E, Amaha M, et al. Ezetimibe reduces urinary albumin excretion in hypercholesterolaemic type 2 diabetes patients with microalbuminuria[J].J Int Med Res,2012,40(2): 798-803.
[18]Wu YG, Lin H, Qi XM, et al. Prevention of early renal injury by mycophenolate mofetil and its mechanism in experimental diabetes[J].Int Immunopharmacol,2006, 6(3): 445-453.
[19]Kodera R, Shikata K, Kataoka HU,et al. Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes[J]. Diabetologia, 2011, 54(4): 965-978.
[20]Navarro-González JF, Mora-Fernández C, Muros de Fuentes M, et al. Effect of pentoxifylline on renal function and urinary albumin excretion in patients with eiabetic kidney disease: the PREDIAN Trial[J]. J Am Soc Nephrol,2015,26(1):220-229.?
[21]Li JJ, Lee SH, Kim DK, et al. Colchicine attenuates inflammatory cell infiltration and extracellular matrix accumulation in diabetic nephropathy[J].Am J Physiol Renal Physiol, 2009,297(1): F200-F209.?
[22]Pan Y, Wang Y, Cai L, et al. Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats[J]. Br J Pharmacol,2012,166(3): 1169-1182.
[23]Lim AK, Ma FY, Nikolic-Paterson DJ, et al. Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice[J].Diabetologia,2009, 52(8): 1669-1679.
[24]Navarro-González JF, Jarque A, Muros M, et al. Tumor necrosis factor-alpha as a therapeutic target for diabetic nephropathy[J]. Cytokine Growth Factor Rev, 2009,20(2): 165-173.

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备注/Memo

备注/Memo:
(收稿日期:2014-09-29)
更新日期/Last Update: 2015-03-24