[1]王兴纯 曲伸.GLP-1分泌的影响因素及调节机制[J].国际内分泌代谢杂志,2015,(01):45-48.[doi:10.3760/cma.j.issn.1673-4157.2015.01.011]
　Wang XingchunQu Shen..Factors affecting GLP-1 secretion and its regulatory mechanism[J].International Journal of Endocrinology and Metabolism,2015,(01):45-48.[doi:10.3760/cma.j.issn.1673-4157.2015.01.011]
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GLP-1分泌的影响因素及调节机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年01
页码:
45-48
栏目:
综述
出版日期:
2015-01-20

文章信息/Info

Title:
Factors affecting GLP-1 secretion and its regulatory mechanism
作者:
王兴纯 曲伸
200072同济大学附属上海市第十人民医院内分泌科；211100 南京医科大学通信作者：曲伸，Email:qushencn@hotmail.com
Author(s):
Wang XingchunQu Shen.
Department of EndocrinologyShanghai 10th Peoples Hospital, Tongji UniversityShanghai 200072ChinaNanjing Medical University, Nanjing 211100, ChinaCorresponding authorQu ShenEmailqushencn@hotmail.com
关键词:
GLP-1; 营养素; 糖尿病
Keywords:
GLP-1; Nutrient; Diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2015.01.011
摘要:
胰高血糖素样肽（GLP）-1能够调节胰岛素的敏感性以及胰岛素的分泌。糖尿病、高脂血症以及胰岛素抵抗相关疾病均与GLP-1的分泌受损有关。GLP-1在多种营养素以及神经内分泌的作用下分泌。不同种类营养素（碳水化合物、脂质、蛋白质、纤维素）的摄入、某些代谢紊乱疾病（如肥胖、糖尿病、非酒精性脂肪性肝病）、药物的干扰、G蛋白耦联受体的水平以及饮食方式等都会对GLP-1的分泌造成一定影响。
Abstract:
Glucagonlike peptide-1(GLP-1) regulates the sensitivity and secretion of insulin. Diabetes, hyperlipidemia and insulin resistance related diseases are associated with the impaired secretion of GLP-1. The secretion of GLP-1 is mediated by a variety of nutrients and neuroendocrine factors. Its secretion is influenced by many factors, such as different nutrient intake (carbohydrate, lipid, protein, fiber)，some metabolic disorders (such as diabetes, obesity, non-alcoholic fatty liver disease), drugs, G protein coupled receptor and eating habits.

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更新日期/Last Update: 2015-03-24