[1]蒋真斌,王明.微小RNA126与糖尿病及其并发症[J].国际内分泌代谢杂志,2014,(04):274-276.[doi:10.3760/cma.j.issn.1673-4157.2014.04.017]
 Jiang Zhenbin*,Wang Ming..Relationship between microRNA 126 with diabetes mellitus and its complications[J].International Journal of Endocrinology and Metabolism,2014,(04):274-276.[doi:10.3760/cma.j.issn.1673-4157.2014.04.017]
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微小RNA126与糖尿病及其并发症()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年04期
页码:
274-276
栏目:
综述
出版日期:
2014-08-31

文章信息/Info

Title:
Relationship between microRNA 126 with diabetes mellitus and its complications
作者:
蒋真斌王明
作者单位:510282 广州,南方医科大学第二临床医学院(蒋真斌);510282 广州,南方医科大学珠江医院中医科(王明)   
Author(s):
Jiang Zhenbin* Wang Ming.
*The Second Medical School of Southern Medical University,Guangzhou 510282,China Corresponding author:Wang Ming,Email:wming@163.com
关键词:
微小RNA126糖尿病糖尿病并发症
Keywords:
MiR-126Diabetes mellitusDiabetic complications
DOI:
10.3760/cma.j.issn.1673-4157.2014.04.017
摘要:
微小RNA126(miR-126)是一种多功能微小RNA,参与糖尿病及其并发症的发生、发展。糖尿病患者血浆中的miR-126浓度明显下降;miR-126通过减少趋化因子配体2(CCL2)分泌抑制脂肪组织胰岛素抵抗;可抑制胰岛素受体底物-1(IRS-1)的表达引起肝细胞胰岛素抵抗;可降低血管内皮生长因子(VEGF)水平,维持内皮祖细胞的增殖、迁移能力并抑制其凋亡,加强CD34+ 外周血单个核细胞的血管生成功能。因此,与miR-126相关的治疗可作为糖尿病及其并发症治疗的新思路。
Abstract:
MicroRNA 126(miR-126) is a kind of multifunctional microRNA,which takes part in the occurrence and development of diabetes mellitus. The concentration of plasma miR-126 in diabetes is decreased. MiR-126 can improve insulin resistance of adipose tissue through reducing the secretion of chemokine ligand 2,and can induce insulin resistance of hepatocytes through inhibiting the expression of insulin receptor substrate-1. MiR-126 reduces the level of vascular endothelial growth factor (VEGF),maintains the proliferation and migration of endothelial progenitor cells,and inhibits their apoptosis, enhances the angiogenic ability of CD34+ peripheral blood mononuclear cell. So miR-126 may provide new therapies for the treatment of diabetes mellitus and its complications.

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备注/Memo

备注/Memo:
基金项目:广东省大学生创新实验计划项目(1212112014);广东省自然科学基金博士启动项目(S2012040007106);广东省卫生厅医学科研基金(B252)南方医科大学科研启动项目 通信作者:王明,Email:wming1999@163.com
更新日期/Last Update: 2014-07-20