[1]姚红,郗光霞,郭敏,等.胰高血糖素样肽-1及其受体在中枢神经系统的分布和功能[J].国际内分泌代谢杂志,2014,(01):36-39.[doi:10.3760/cma.j.issn.1673-4157.2014.01.010]
 Yao Hong*,Xi Guangxia,Guo Min,et al.The distributions and functions of glucagon like peptide-1 and its receptors in the central nervous system[J].International Journal of Endocrinology and Metabolism,2014,(01):36-39.[doi:10.3760/cma.j.issn.1673-4157.2014.01.010]
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胰高血糖素样肽-1及其受体在中枢神经系统的分布和功能()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年01期
页码:
36-39
栏目:
综述
出版日期:
2014-02-28

文章信息/Info

Title:
The distributions and functions of glucagon like peptide-1 and its receptors in the central nervous system
作者:
姚红郗光霞郭敏杨娜
030001 太原,山西医科大学(姚红,郭敏,杨娜);030032 太原,山西医学科学院,山西大医院内分泌科(郗光霞)   
Author(s):
Yao Hong*Xi GuangxiaGuo MinYang Na.
*Shanxi Medical University,Taiyuan 030001,China Corresponding author:Xi Guangxia,Email:bettyxgx2006@hotmail.com
关键词:
胰高血糖素样肽-1中枢神经系统下丘脑食欲葡萄糖稳态
Keywords:
Glucagon like peptide-1Central nervous systemHypothalamusAppetiteGlucose homeostasis
DOI:
10.3760/cma.j.issn.1673-4157.2014.01.010
摘要:
胰高糖素样肽-1(GLP-1)由中枢神经系统第四脑室边缘的孤束核尾部神经细胞分泌,后运输至下丘脑室旁核和背侧核。 而其受体在中枢神经系统的分布主要集中在下丘脑,尤其是弓状核和室旁核、背内侧核、视上核。GLP-1通过与下丘脑相应核团上GLP-1受体结合,调节机体的多种生理功能,包括负向调节机体的摄食以及饮水行为、胃排空的速度,促进骨骼肌葡萄糖的摄取和糖原合成,降低血浆葡萄糖浓度,上调机体心率及降低血压等,从而起到调节机体的代谢水平及多重心血管保护的作用。
Abstract:
Glucagon like peptide-1(GLP-1) is secreted by nerve cells of the fourth ventricle solitary nucleus in central nervous system, which is transported to hypothalamus paraventricular nucleus and dorsal nucleus.Its receptors are mainly concentrated in hypothalamus,especially the arcuate nucleus and paraventricular nucleus,dorsal medial nucleus,supraoptic nucleus.GLP-1 could regulate a variety of physiological functions of the body through combining with GLP-1 receptors on the hypothalamic nuclei, including the negative regulation of feeding and drinking behavior of the body,the rate of gastric emptying, promoting skeletal muscle glucose uptake and glycogen synthesis,reducing plasma glucose concentration,increasing heart rate while lowering blood pressure,and so on.Thus it plays an important role in the protection of cardiovascular and regulation the metabolism of the body.

参考文献/References:

[1] Dhanesha N,Joharapurkar A,Shah G,et al.Exendin-4 reduces glycemia by increasing liver glucokinase activity:an insulin independent effect[J].Pharmacol Rep,2012,64(1):140-149.
[2] Llewellyn-Smith IJ,Reimann F,Gribble FM,et al.Preproglucagon neurons project widely to autonomic control areas in the mouse brain[J].Neuroscience,2011,180:111-121.
[3] Tauchi M,Zhang R,D'Alessio DA.Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei[J].J Chem Neuroanat,2008,36(3-4):144-149.
[4] 梁少双,魏良洲,雪田,等.下丘脑室旁核注射GLP-1对糖尿病大鼠中枢GLP-1受体表达与胃排空的影响[J].现代生物医学进展,2012,12(8):1452-1456.
[5] Alhadeff AL,Rupprecht LE,Hayes MR.GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake[J].Endocrinology,2012,153(2):647-658.
[6] Sandoval DA,Bagnol D,Woods SC,et al.Arcuate glucagon-like peptide-1 receptors regulate glucose homeostasis but not food intake[J]. Diabetes,2008,57(8):2046-2054.
[7] Scott MM,Williams KW,Rossi J,et al.Leptin receptor expres-sion in hindbrain GLP-1 neurons regulates food intake and energy balance in mice[J].J Clin Invest,2011,121(6):2413-2421.
[8] Seo S,Ju S,Chung H,et al.Acute effects of glucagon-like peptide-1 on hypothalamic neuropeptide and AMP activated kinase expression in fasted rats[J].Endocr J,2008,55(5):867-874.
[9] Rüttimann EB,Arnold M,Hillebrand JJ,et al.Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms[J].Endocrinology,2009,150(3):1174-1181.
[10] Williams DL,Baskin DG,Schwartz MW.Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety[J].Endocrinology,2009,150(4):1680-1687.
[11] Dickson SL,Shirazi RH,Hansson C,et al.The glucagon-like peptide-1(GLP-1)analogue,exendin-4,decreases the rewarding value of food:a new role for mesolimbic GLP-1 receptors[J].J Neurosci,2012, 32(14):4812-4820.
[12] Folli F,Guardado Mendoza R.Potential use of exenatide for the treatment of obesity[J].Expert Opin Investig Drugs,2011,20(12):1717-1722.
[13] Washington MC,Raboin SJ,Thompson W,et al.Exenatide reduces food intake and activates the enteric nervous system of the gastrointestinal tract and the dorsal vagal complex of the hindbrain in the rat by a GLP-1 receptor[J].Brain Res,2010,1344:124-133.
[14] Radziszewska E,Bojanowska E.Effects of glucagon-like peptide-1 receptor stimulation and blockade on food consumption and body weight in rats treated with a cannabinoid CB1 receptor agonist WIN 55,212-2[J].Med Sci Monit Basic Res,2013,19:6-11.
[15] Knauf C,Cani PD,Ait-Belgnaoui A,et al.Brain glucagon-like peptide-1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure[J].Endocrinology,2008,149(10):4768-4777.
[16] Cabou C,Campistron G,Marsollier N,et al.Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate,and insulin sensitivity[J].Diabetes,2008,57(10):2577-2587.
[17] Nishizawa M,Nakabayashi H,Uehara K,et al.Intraportal GLP-1 stimulates insulin secretion predominantly through the hepatoportal-pancreatic vagal reflex pathways[J].Am J Physiol Endocrinol Metab, 2013,305(3):E376-E387.
[18] Baumgartner I,Pacheco-López G,Rüttimann EB,et al.Hepatic-portal vein infusions of glucagon-like peptide-1 reduce meal size and increase c-Fos expression in the nucleus tractus solitarii,area postrema and central nucleus of the amygdala in rats[J].J Neuroendocrinol,2010, 22(6):557-563.
[19] Robinson LE,Holt TA,Rees K,et al.Effects of exenatide and liraglutide on heart rate, blood pressure and body weight: systematic review and meta-analysis[J].BMJ Open,2013,3(1):e001986.
[20] Plamboeck A,Veedfald S,Deacon CF,et al.The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty[J].Am J Physiol Gastrointest Liver Physiol,2013,304(12):G1117-G1127.
[21] Gu G,Roland B,Tomaselli K,et al.Glucagon-like peptide-1 in the rat brain:distribution of expression and functional implication[J].J Comp Neurol,2013,521(10):2235-2261.
[22] Gill A,Hoogwerf BJ,Burger J,et al.Effect of exenatide on heart rate and blood pressure in subjects with type 2 diabetes mellitus:a double-blind,placebo-controlled,randomized pilot study[J].Cardiovasc Diabetol,2010,9:6.
[23] Okerson T,Yan P,Stonehouse A,et al.Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes[J].Am J Hypertens,2010,23(3):334-339.
[24] Halbirk M,Nφrrelund H,Mφller N,et al.Cardiovascular and metabolic effects of 48-h glucagon-like peptide-1 infusion in compensated chronic patients with heart failure[J].Am J Physiol Heart Circ Physiol,2010,298(3):H1096-H1102.
[25] Verge D,López X.Impact of GLP-1 and GLP-1 receptor agonists on cardiovascular risk factors in type 2 diabetes[J].Curr Diabetes Rev,2010,6(4):191-200.

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备注/Memo

备注/Memo:
基金项目:山西省基础研究项目(2013011048-3);山西省回国留学人员基金(2011-108) 通信作者:郗光霞,Email:bettyxgx2006@hotmail.com
更新日期/Last Update: 2014-01-20