[1]何志伟,黄文彬,杨雪,等.下丘脑-垂体-甲状腺轴对胰岛β细胞的调控作用[J].国际内分泌代谢杂志,2023,43(06):517-520.[doi:10.3760/cma.j.cn121383-20220928-09053]
 He Zhiwei,Huang Wenbin,Yang Xue,et al.Regulation of the hypothalamic-pituitary-thyroid axis on islet β cells[J].International Journal of Endocrinology and Metabolism,2023,43(06):517-520.[doi:10.3760/cma.j.cn121383-20220928-09053]
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下丘脑-垂体-甲状腺轴对胰岛β细胞的调控作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
43
期数:
2023年06期
页码:
517-520
栏目:
综述
出版日期:
2023-11-20

文章信息/Info

Title:
Regulation of the hypothalamic-pituitary-thyroid axis on islet β cells
作者:
何志伟黄文彬杨雪陈煜刘超
南京中医药大学附属中西医结合医院内分泌科,南京 210028
Author(s):
He Zhiwei Huang Wenbin Yang Xue Chen Yu Liu Chao.
Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine; Nanjing 210028, China
关键词:
下丘脑-垂体-甲状腺轴 甲状腺激素 促甲状腺激素 促甲状腺激素释放激素 胰岛β细胞
Keywords:
Hypothalamic-pituitary-thyroid axis Thyroid hormone Thyroid stimulating hormone Thyrotropin releasing hormone Pancreatic β cell
DOI:
10.3760/cma.j.cn121383-20220928-09053
摘要:
下丘脑-垂体-甲状腺轴(HPTA)是调节甲状腺激素合成与分泌的负反馈运转机制。胰岛β细胞是胰岛细胞中的一种,其功能受损是导致糖尿病发病的关键机制。研究表明,HPTA在维持胰岛β细胞功能的过程中扮演重要角色。甲状腺激素能促进胰岛β细胞发育、成熟和衰老,不同浓度的三碘甲状腺原氨酸能调控β细胞的增殖、凋亡,并影响其分泌功能。促甲状腺激素可通过上调葡萄糖转运蛋白2的表达直接影响β细胞对葡萄糖的摄取,并可与β细胞上的促甲状腺素受体结合影响胰岛素分泌。促甲状腺激素释放激素具有刺激胰岛素分泌基因表达的作用,能促进β细胞增殖和减少凋亡。探究HPTA对胰岛β细胞的调控作用,有望为糖尿病的防治提供新思路。
Abstract:
The hypothalamic-pituitary-thyroid axis(HPTA)is a negative feedback mechanism that regulates the synthesis and secretion of thyroxine. Impaired function of pancreatic β cells, is a key mechanism contributing to the development of diabetes mellitus. Studies have shown that HPTA plays an important role in maintaining the function of pancreatic β cells. Thyroid hormone can promote the development, maturation and senescence of β cells, and different concentrations of triiodothyronine can regulate the proliferation and apoptosis of β cells, and affect the secretory function of β cells. Thyrotropin can directly affect the uptake of glucose by β cells by up-regulating the expression of glucose transporter 2 and affect the function of insulin secretion through binding to thyrotropin receptors on β cells. Thyrotropin-releasing hormone has the effect of stimulating insulin secretion gene expression, promoting β cell proliferation and reducing apoptosis. Exploring the regulatory effects of HPTA on pancreatic β cells is expected to provide new ideas for the prevention and treatment of diabetes.

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备注/Memo

备注/Memo:
基金项目:2022年江苏省研究生科研创新计划(KYCX22-2060)
通信作者:刘超,Email: liuchao@nfmcn.com
更新日期/Last Update: 2023-12-30