[1]林娇娇,蔡星璇,周竟雄.铁缺乏对妊娠期甲状腺功能影响的研究进展[J].国际内分泌代谢杂志,2021,41(01):24-27.[doi:10.3760/cma.j.cn121383-20200519-05054]
　Lin Jiaojiao,Cai Xingxuan,Zhou Jingxiong..Research progress of the effect of iron deficiency on thyroid function during pregnancy[J].International Journal of Endocrinology and Metabolism,2021,41(01):24-27.[doi:10.3760/cma.j.cn121383-20200519-05054]
点击复制

铁缺乏对妊娠期甲状腺功能影响的研究进展()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年01期
页码:
24-27
栏目:
甲状腺疾病专题
出版日期:
2021-01-20

文章信息/Info

Title:
Research progress of the effect of iron deficiency on thyroid function during pregnancy
作者:
林娇娇; 蔡星璇; 周竟雄
福建医科大学附属第二医院内分泌科,泉州 362000
Author(s):
Lin Jiaojiao;  Cai Xingxuan;  Zhou Jingxiong.
Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China
关键词:
铁缺乏症;  甲状腺功能减退症;  妊娠;  补铁治疗
Keywords:
Iron deficiency;  Hypothyroidism;  Pregnancy;  Iron supplementation
DOI:
10.3760/cma.j.cn121383-20200519-05054
摘要:
铁缺乏症(iron deficiency,ID)会增加妊娠期甲状腺功能减退症(甲减)的发生风险。目前认为其发生与甲状腺轴及核受体介导的信号转导通路、甲状腺过氧化物酶及脱碘酶活性、甲状腺自身免疫损伤以及补碘效果等有关。近来研究显示,补铁治疗能够改善甲状腺功能并缓解甲减患者的症状,提示铁剂可能在妊娠期甲减的治疗中扮演重要角色。但目前尚缺乏妊娠期特异的ID诊断标准,并且铁剂的应用剂量和疗程不一,今后仍需开展更多关于铁剂补充对改善妊娠期ID患者甲状腺功能及妊娠结局的研究。
Abstract:
Iron deficiency(ID)increases the risk of hypothyroidism during pregnancy. At present, it is believed that its occurrence is related to thyroid axis and nuclear receptor pathway, thyroid peroxidase and deiodinase activity, thyroid autoimmune damage and the effect of iodine supplement. Recent studies have shown that iron supplementation can improve thyroid function and relieve symptoms in patients with hypothyroidism, suggesting that iron may play an important roles in the treatment of hypothyroidism during pregnancy. However, at present, there is a lack of pregnancy-specific diagnostic criteria for ID, and the dosage and course of treatment of iron are different. In the future, more studies on the effects of iron supplementation on improving thyroid function and pregnancy outcomes in patients with pregnancy-related ID need to be carried out.

参考文献/References:

[1] 中华医学会内分泌学分会,中华医学会围产医学分会编撰委员会. 妊娠和产后甲状腺疾病诊治指南(第2版)[J]. 中华内分泌代谢杂志,2019,35(8):636-665.DOI:10.3760/cma.j.issn.1000-6699.2019.08.003.
[2] 刘正云,张克勤. 妊娠合并甲状腺过氧化物酶抗体阳性状态对妊娠结局及后代的影响[J]. 国际内分泌代谢杂志,2014,34(4):253-256.DOI:10.3760/cma.j.issn.1673-4157.2014.04.011.
[3] 何国琳,孙鑫,谭婧,等. 中国部分城市妊娠期铁缺乏和缺铁性贫血患病率的调查[J]. 中华妇产科杂志,2018,53(11):761-767.DOI:10.3760/cma.j.issn.0529-567x.2018.11.006.
[4] Gupt PM,Hamner HC,Suchdev PS,et al. Iron status of toddlers,nonpregnant females,and pregnant females in the United States[J].Am J Clin Nutr,2017,106(Suppl 6):1640S-1646S.DOI:10.3945/ajcn.117.155978.
[5] Teng X,Shan Z,Li C,et al. Iron deficiency may predict greater risk for hypothyroxinemia:a retrospective cohort study of pregnant women in china[J].Thyroid,2018,28(8):968-975.DOI:10.1089/thy.2017.0491.
[6] Veltri F,Decaillet S,Kleynen P,et al. Prevalence of thyroid autoimmunity and dysfunction in women with iron deficiency during early pregnancy:Is it altered?[J].Eur J Endocrinol,2016,175(3):191-199.DOI:10.1530/EJE-16-0288.
[7] Hanif S,Ilyas A,Shah MH. Statistical evaluation of trace metals,TSH and T4 in blood serum of thyroid disease patients in comparison with controls[J].Biol Trace Elem Res,2018,183(1):58-70.DOI:10.1007/s12011-017-1137-5.
[8] He L,Shen C,Zhang Y,et al. Evaluation of serum ferritin and thyroid function in the second trimester of pregnancy[J].Endocr J,2018,65(1):75-82.DOI:10.1507/endocrj.EJ17-0253.
[9] Li S,Gao X,Wei Y,et al. The relationship between iron deficiency and thyroid function in chinese women during early pregnancy[J].J Nutr Sci Vitaminol,2016,62(6):397-401.DOI:10.3177/jnsv.62.397.
[10] Bastian TW,Prohaska JR,Georgieff MK,et al. Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations[J].Endocrinology,2010,151(8):4055-4065.DOI:10.1210/en.2010-0252.
[11] Beard J,Tobin B,Green W. Evidence for thyroid hormone deficiency in iron-deficient anemic rats[J].J Nutr Sci Vitaminol,1989,119(5):772-778.DOI:10.1093/jn/119.5.772.
[12] Shan Z,Teng W. Thyroid hormone therapy of hypothyroidism in pregnancy[J].Endocrine,2019,66(1):35-42.DOI:10.1007/s12020-019-02044-2.
[13] Rayman MP. Multiple nutritional factors and thyroid disease,with particular reference to autoimmune thyroid disease[J].Proc Nutr Soc,2019,78(1):34-44.DOI:10.1017/S0029665118001192.
[14] Hess SY,Zimmermann MB,Arnold M,et al. Iron deficiency anemia reduces thyroid peroxidase activity in rats[J].J Nutr,2002,132(7):1951-1955.DOI:10.1093/jn/132.7.1951.
[15] Brigham DE,Beard JL. Effect of thyroid hormone replacement in iron-deficient rats[J].Am J Physiol,1995,269(5 Pt 2):R1140-R1147.DOI:10.1152/ajpregu.1995.269.5.R1140.
[16] 林康杰,杨小敏. 妊娠生理因素对甲状腺结节发病影响的研究进展[J].医学信息,2019,32(9):41-44.DOI:CNKI:SUN:YXXX.0.2019-09-014.
[17] Maldonado-Araque C,Valdés S,Lago-Sampedro A,et al. Iron deficiency is associated with Hypothyroxinemia and Hypotriiodothyroninemia in the Spanish general adult population:Di@bet.es study[J].Sci Rep,2018,8(1):6571.DOI:10.1038/s41598-018-24352-9.
[18] Hess SY,Zimmermann MB,Adou P,et al. Treatment of iron defificiency in goitrous children improves the effificacy of iodized salt in cote d'ivoire[J].Am J Clin Nutr,2002,75(4):743-748.DOI:10.1093/ajcn/75.4.743.
[19] Shakir KM,Turton D,Aprill BS,et al. Anemia:a cause of intolerance to thyroxine sodium[J].Mayo Clin Proc,2000,75(2):189-192.DOI:10.4065/75.2.189.
[20] Soppi E. Iron defificiency is the main cause of symptom persistence in patients treated for hypothyroidism[A].15th International Thyroid Congress,Thyroid 25,2015,A-74.
[21] Ravanbod M,Asadipooya K,Kalantarhormozi M,et al. Treatment of iron-deficiency anemia in patients with subclinical hypothyroidism[J].Am J Med,2013,126(5):420-424.DOI:10.1016/j.amjmed.2012.12.009.
[22] 中华医学会围产医学分会编撰委员会. 妊娠期铁缺乏和缺铁性贫血诊治指南[J].中华围产医学杂志,2014,17(7):451-454.DOI:10.3760/cma.j.issn.1007-9408.2014.07.006.

相似文献/References:

[1]朱丹,陈国芳,刘超,等.糖尿病患者合并甲状腺功能异常的机制 及其影响[J].国际内分泌代谢杂志,2016,36(03):206.[doi:10.3760/cma.j.issn.1673-4157.2016.03.16]
　Zhu Dan*,Chen Guofang,Liu Chao,et al.Mechanisms of diabetes combined with thyroid dysfunction and its influence[J].International Journal of Endocrinology and Metabolism,2016,36(01):206.[doi:10.3760/cma.j.issn.1673-4157.2016.03.16]
[2]戴雨桑 时立新.吸烟与甲状腺功能减退症[J].国际内分泌代谢杂志,2018,38(06):390.[doi:10.3760/cma.j.issn.1673-4157.2018.06.007]
　Dai Yusang*,Shi Lixin.Smoking and hypothyroidism[J].International Journal of Endocrinology and Metabolism,2018,38(01):390.[doi:10.3760/cma.j.issn.1673-4157.2018.06.007]
[3]张超,王先令,陈予龙,等.136例POEMS综合征患者内分泌代谢异常的临床特点回顾性分析[J].国际内分泌代谢杂志,2021,41(01):38.[doi:10.3760/cma.j.cn121383-20200413-04035]
　Zhang Chao,Wang Xianling,Chen Yulong,et al.Retrospective analysis of the clinical characteristics of endocrine-metabolic abnormalities in 136 patients with POEMS syndrome[J].International Journal of Endocrinology and Metabolism,2021,41(01):38.[doi:10.3760/cma.j.cn121383-20200413-04035]

备注/Memo

备注/Memo:
通信作者:周竟雄,Email:zhoujx88@sina.com
更新日期/Last Update: 2021-01-20