[1]顾朋颖,叶山东.骨钙素与动脉粥样硬化关系的研究进展[J].国际内分泌代谢杂志,2014,(03):197-199.[doi:10.3760/cma.j.issn.1673-4157.2014.03.015]
 Gu Pengying*,Ye Shandong..Relationship between osteocalcin and atherosclerosis[J].International Journal of Endocrinology and Metabolism,2014,(03):197-199.[doi:10.3760/cma.j.issn.1673-4157.2014.03.015]
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骨钙素与动脉粥样硬化关系的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年03期
页码:
197-199
栏目:
综述(基础研究)
出版日期:
2014-06-30

文章信息/Info

Title:
Relationship between osteocalcin and atherosclerosis
作者:
顾朋颖叶山东
230001 安徽医科大学附属省立医院干部病房(顾朋颖);安徽医科大学附属省立医院内分泌科(叶山东)   
Author(s):
Gu Pengying*Ye Shandong.
*Department of Old Geriatrics,Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001,China Corresponding author: Ye Shandong,Email:ysd1964@163.com
关键词:
骨钙素动脉粥样硬化能量代谢
Keywords:
OsteocalcinAtherosclerosisEnergy metabolism
DOI:
10.3760/cma.j.issn.1673-4157.2014.03.015
摘要:
骨钙素是一种由成骨细胞合成和分泌的非胶原蛋白,其分泌受到多种激素、维生素和细胞因子的调节。近年来研究发现骨钙素与机体能量代谢密切相关,具有调节脂肪含量、促进胰岛β细胞增殖、增强胰岛素敏感性等作用。而且与动脉粥样硬化严重程度相关,可能是一个血管保护因子,在动脉粥样硬化的发生中发挥一定作用。深入研究骨钙素的生物学作用可能为动脉粥样硬化的防治提供新的靶点。
Abstract:
Osteocalcin,which is a non-collagenous protein,is specifically synthetized and secreted by the osteoblast,and regulated by many kinds of hormones,vitamins and cytokines.Recently,studies have found that osteocalcin is related to energy metabolism,and plays important roles in regulating the content of fat,promoting the proliferation of islet β cells,enhancing insulin sensitivity and so on. Moreover,it is related to the severity of atherosclerosis,therefore it may be a vascular protection factor and plays a key role in the occurrence of atherosclerosis. Further study of the biological significance of osteocalcin may provide new targets for prevention and treatment of atherosclerosis.

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备注/Memo

备注/Memo:
基金项目:安徽省卫生厅资助项目(13zc010) 通信作者,叶山东,Email: ysd196406@163.com
更新日期/Last Update: 2014-05-20