参考文献/References:
[1] Chooi YC,Ding C,Magkos F.The epidemiology of obesity[J].Metabolism,2019,92:6-10.DOI:10.1016/j.metabol.2018.09.005.
[2] Cheng L,Wang J,Dai H,et al.Brown and beige adipose tissue:a novel therapeutic strategy for obesity and type 2 diabetes mellitus[J].Adipocyte,2021,10(1):48-65.DOI:10.1080/21623945.2020.1870060.
[3] Ajoolabady A,Liu S,Klionsky DJ,et al.ER stress in obesity pathogenesis and management[J].Trends Pharmacol Sci,2022,43(2):97–109.DOI:10.1016/j.tips.2021.11.011.
[4] Zha BS,Zhou H.ER stress and lipid metabolism in adipocytes[J].Biochem Res Int,2012,2012:312943.DOI:10.1155/2012/312943.
[5] Wang R,Li B,Lam SM,et al.Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression[J].J Genet Genomics,2020,47(2):69-83.DOI:10.1016/j.jgg.2019.11.009.
[6] Qiang G,Whang Kong H,Gil V,et al.Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction[J].Sci Rep,2017,7:40215.DOI:10.1038/srep40215.
[7] He P,Hou B,Li Y,et al.Lipid profiling reveals browning heterogeneity of white adipose tissue by Β3-Adrenergic stimulation[J].Biomolecules,2019,9(9):444.DOI:10.3390/biom9090444.
[8] Rhee EP,Cheng S,Larson MG,et al.Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans[J].J Clin Invest,2011,121(4):1402-1411.DOI:10.1172/JCI44442.
[9] Szendroedi J,Yoshimura T,Phielix E,et al.Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans[J].Proc Natl Acad Sci U S A,2014,111(26):9597-9602.DOI:10.1073/pnas.1409229111.
[10] Liu L,Trent CM,Fang X,et al.Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1(DGAT1)reproduces the abnormalities in lipids found in severe heart failure[J].J Biol Chem,2014,289(43):29881-29891.DOI:10.1074/jbc.M114.601864.
[11] Akoumi A,Haffar T,Mousterji M,et al.Palmitate mediated diacylglycerol accumulation causes endoplasmic reticulum stress,Plin2 degradation,and cell death in H9C2 cardiomyoblasts[J].Exp Cell Res,2017,354(2):85-94.DOI:10.1016/j.yexcr.2017.03.032.
[12] Jayasinghe SU,Tankeu AT,Amati F.Reassessing the role of diacylglycerols in insulin resistance[J].Trends Endocrinol Metab,2019,30(9):618-635.DOI:10.1016/j.tem.2019.06.005.
[13] Ni Y,Zhao L,Yu H,et al.Circulating unsaturated fatty acids delineate the metabolic status of obese individuals[J].EbioMedicine,2015,2(10):1513-1522.DOI:10.1016/j.ebiom.2015.09.004.
[14] Zhao X,Feng X,Zhao X,et al.How to screen and prevent metabolic syndrome in Patients of PCOS early:implications from metabolomics[J].Front Endocrinol(Lausanne),2021,12:659268.DOI:10.3389/fendo.2021.659268.
[15] Liu ZC,Wu WH,Huang S,et al.Plasma lipids signify the progression of precancerous gastric lesions to gastric cancer:a prospective targeted lipidomics study[J].Theranostics,2022,12(10):4671-4683.DOI:10.7150/thno.74770.
[16] Zhou X,Mei H,Agee J,et al.Racial differences in distribution of fatty acids in prostate cancer and benign prostatic tissues[J].Lipids Health Dis,2019,18(1):189.DOI:10.1186/s12944-019-1130-4.
[17] Lu J,Lam SM,Wan Q,et al.High-Coverage targeted lipidomics reveals novel serum lipid predictors and lipid pathway dysregulation antecedent to type 2 diabetes onset in normoglycemic Chinese adults[J].Diabetes Care,2019,42(11):2117-2126.DOI:10.2337/dc19-0100.
[18] Zhou X,Mao J,Peng W,et al.The association of prostatic lipids with progression,racial disparity and discovery of biomarkers in prostate cancer[J].Transl Oncol,2021,14(12):101218.DOI:10.1016/j.tranon.2021.101218.
[19] Showalter MR,Berg AL,Nagourney A,et al.The emerging and diverse roles of bis(monoacylglycero)phosphate lipids in cellular physiology and disease[J].Int J Mol Sci,2020,21(21):8067.DOI:10.3390/ijms21218067.
[20] Grabner GF,Fawzy N,Pribasnig MA,et al.Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans[J].J Lipid Res,2019,60(5):1020-1031.DOI:10.1194/jlr.M093351.
[21] Rampanelli E,Ochodnicky P,Vissers JP,et al.Excessive dietary lipid intake provokes an acquired form of lysosomal lipid storage disease in the kidney[J].J Pathol,2018,246(4):470-484.DOI:10.1002/path.5150.
[22] d'Avignon DA,Puchalska P,Ercal B,et al.Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome[J].JCI Insight,2018,3(12):e99762.DOI:10.1172/jci.insight.99762.
[23] Eisinger K,Liebisch G,Schmitz G,et al.Lipidomic analysis of serum from high fat diet induced obese mice[J].Int J Mol Sci,2014,15(2):2991-3002.DOI:10.3390/ijms15022991.
[24] Aerts JM,Ottenhoff R,Powlson AS,et al.Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity[J].Diabetes,2007,56(5):1341-1349.DOI:10.2337/db06-1619.
[25] Zhao H,Przybylska M,Wu IH,et al.Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes[J].Diabetes,2007,56(5):1210-1218.DOI:10.2337/db06-0719.
[26] Boslem E,MacIntosh G,Preston AM,et al.A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum(ER)stress and impaired protein trafficking[J].Biochem J,2011,435(1):267-276.DOI:10.1042/BJ20101867.
[27] Yang L,Li M,Shan Y,el al.Recent advances in lipidomics for disease research[J].J Sep Sci,2016,39(1):38-50.DOI:10.1002/jssc.201500899.
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