[1]陈莹 倪文婧 陈国芳 徐书杭.基于复发危险因素探讨Graves病治疗的新策略[J].国际内分泌代谢杂志,2022,42(04):260-263.[doi:10.3760/cma.j.cn121383-20210412-04031]
 Chen Ying,Ni Wenjing,Chen Guofang,et al.New strategies for the treatment of Graves' disease based on risk factors of relapse[J].International Journal of Endocrinology and Metabolism,2022,42(04):260-263.[doi:10.3760/cma.j.cn121383-20210412-04031]
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基于复发危险因素探讨Graves病治疗的新策略()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年04期
页码:
260-263
栏目:
综述
出版日期:
2022-07-20

文章信息/Info

Title:
New strategies for the treatment of Graves' disease based on risk factors of relapse
作者:
陈莹 倪文婧 陈国芳 徐书杭
南京中医药大学附属中西医结合医院,江苏省中医药研究院,内分泌科 210028
Author(s):
Chen Ying Ni Wenjing Chen Guofang Xu Shuhang.
Department of Endocrinology, the Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China
关键词:
Graves病 复发 免疫调节 热消融
Keywords:
Graves' disease Relapse Immunomodulation Thermal ablation
DOI:
10.3760/cma.j.cn121383-20210412-04031
摘要:
Graves病是针对甲状腺滤泡细胞膜上促甲状腺激素受体(TSHR)产生的促甲状腺激素受体抗体(TRAb)所引起的一种自身免疫性疾病。目前,抗甲状腺药物(ATD)仍然是Graves病治疗的一线方案,但停药后的高复发率一直是治疗的棘手难题。近年来随着临床上对Graves病低复发率的需求增加及对复发危险因素的不断探索,一些针对B淋巴细胞、TSHR介导的免疫反应的靶向药物,以及改善甲状腺肿大的新药物及新技术不断涌现,未来Graves病的治疗将出现更多新的选择。
Abstract:
Graves' disease is an autoimmune disease and caused by thyroid stimulating hormone receptor antibody(TRAb)targeting TSH receptor(TSHR)on the membrane of thyroid follicular cells. At present, antithyroid drugs(ATD)are still the first-line therapy for Graves' disease, but the high recurrence rate after drug withdrawal has always been a thorny problem. In recent years, with the clinical demand for low recurrence rate of Graves' disease and the continuous exploration of recurrence risk factors, some targeted drugs for B lymphocytes and TSHR mediated immune response, as well as new drugs and new technologies to improve goiter are emerging. Therefore new therapeutic strategies may be available to improve the management of Graves' disease.

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备注/Memo

备注/Memo:
基金项目:江苏省重点研发计划(BE2020726); 江苏省卫生健康委医学科研项目(M2020102)
通信作者:徐书杭,Email:shuhangxu@163.com
更新日期/Last Update: 2022-06-20