[1]龙丽 张秀英 纪立农.甲状腺相关眼病治疗新希望——IGF-Ⅰ受体拮抗剂[J].国际内分泌代谢杂志,2022,42(04):256-259.[doi:10.3760/cma.j.cn121383-20210420-04055]
 Long Li,Zhang Xiuying,Ji Linong..New hope for the treatment of thyroid associated orbitopathy-IGF-Ⅰ receptor antagonist[J].International Journal of Endocrinology and Metabolism,2022,42(04):256-259.[doi:10.3760/cma.j.cn121383-20210420-04055]
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甲状腺相关眼病治疗新希望——IGF-Ⅰ受体拮抗剂()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年04期
页码:
256-259
栏目:
综述
出版日期:
2022-07-20

文章信息/Info

Title:
New hope for the treatment of thyroid associated orbitopathy-IGF-Ⅰ receptor antagonist
作者:
龙丽12 张秀英1 纪立农1
1北京大学人民医院内分泌科 100044; 2贵阳市第二人民医院内分泌科 550001
Author(s):
Long Li12 Zhang Xiuying1 Ji Linong1.
1Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing 100044, China; 2Department of Endocrinology and Metabolism, the Second People's Hospital, Guiyang 550001, China
关键词:
甲状腺功能亢进症 Graves病 甲状腺相关性眼病 胰岛素样生长因子Ⅰ受体 Teprotumumab
Keywords:
Hyperthyroidism Graves' disease Thyroid associated orbitopathy Insulin-like growth factor-Ⅰ receptor Teprotumumab
DOI:
10.3760/cma.j.cn121383-20210420-04055
摘要:
甲状腺相关性眼病(thyroid associated orbitopathy,TAO)也称为Graves眼病,多见于女性,是一种进行性、具有潜在致盲风险的自身免疫性疾病。既往用于中重度活动性TAO的治疗药物虽然有多种,但疗效均不够确切,不能满足临床需求。随着对TAO发病机制的研究不断深入,胰岛素样生长因子Ⅰ(insulin-like growth factor-Ⅰ, IGF-Ⅰ)受体介导通路在TAO发生、发展过程中的作用得到肯定。新型靶向药物IGF-Ⅰ受体拮抗剂(如Teprotumumab)用于TAO治疗的多项临床试验取得了良好疗效,为有效治疗TAO带来希望。
Abstract:
Thyroid associated orbitopathy(TAO), also known as Graves' orbitopathy, is a progressive autoimmune disease with potential blindness risk that occurs more common in women. A variety of drugs have been used in the treatment of moderate and severe active TAO in the past decades,but the benefits are not satisfactory. With the in-depth research on the pathogenesis of TAO, the role of insulin-like growth factor-Ⅰ(IGF-Ⅰ)receptor-mediated pathway in the development of TAO has attracted more and more attention. A number of clinical trials using new targeted drugs IGF-Ⅰ receptor antagonists(e.g.Teprotumumab)on the treatment of TAO have achieved good outcomes, which brings new hope for effective treatment of TAO.

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备注/Memo

备注/Memo:
通信作者:张秀英,Email:zhangxiuying717@163.com
更新日期/Last Update: 2022-06-20