[1]黄丽君.环状RNA的功能及其在甲状腺乳头状癌中的作用[J].国际内分泌代谢杂志,2022,42(01):58-62.[doi:10.3760/cma.j.cn121383-20200927-09052]
 Huang Lijun..Function of circRNAs and its role in thyroid papillary carcinoma[J].International Journal of Endocrinology and Metabolism,2022,42(01):58-62.[doi:10.3760/cma.j.cn121383-20200927-09052]
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环状RNA的功能及其在甲状腺乳头状癌中的作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年01期
页码:
58-62
栏目:
综述
出版日期:
2022-01-20

文章信息/Info

Title:
Function of circRNAs and its role in thyroid papillary carcinoma
作者:
黄丽君
广东医科大学附属医院国际医疗与特需医疗部,湛江 524001
Author(s):
Huang Lijun.
Department of International Medicine and Special Needs, the Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
关键词:
环状RNA 甲状腺乳头状癌 生物标志物
Keywords:
CircularRNA Papillary thyroid carcinoma Biomarker
DOI:
10.3760/cma.j.cn121383-20200927-09052
摘要:
环状RNA(circRNA)是一种新型的长链非编码RNA(ncRNA),具有共价闭环的特征,不受RNA外切酶影响,相较线性RNA更加稳定。研究表明,circRNA在调节细胞的生理病理过程中具有小分子RNA(miRNA)的海绵效应、调控基因剪接和转录、充当自噬调节剂与RNA结合蛋白的相互作用、翻译蛋白质等重要作用。甲状腺乳头状癌(PTC)是最常见的甲状腺恶性肿瘤类型,约占所有甲状腺恶性肿瘤病例的90%,PTC多数预后良好,但部分患者复发率高,预后差。近年来越来越多的研究发现circRNA在PTC的发生和发展中具有重要作用,表明circRNA作为生物标志物的功能及其在该疾病中的治疗意义。
Abstract:
CircularRNA(circRNA)is a new type of long non-coding RNA(ncRNA)with covalent closed-loop characteristics, which is not Affected by RNA exonuclease and is more stable than linear RNA.Studies have shown that circRNA plays an important role in regulating the physiological and pathological processes of cells, such as the sponge effect of miRNA, regulating gene splicing and transcription, acting as an autophagy regulator and the interaction between RNA binding proteins, and translating proteins.Papillary thyroid carcinoma(PTC)is the most common thyroid malignant tumor type, accounting for more than 90% of all thyroid malignant tumor cases. Most PTC patients have a good prognosis, but some patients have a high recurrence rate and a poor prognosis.In recent years, more and more studies have found that circRNA plays an important role in the occurrence and development of PTC, indicating the function of circRNA as a biomarker and its therapeutic significance in this disease.

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备注/Memo

备注/Memo:
通信作者:黄丽君,Email:lijunhuang_2018@163.com
更新日期/Last Update: 2022-01-20