[1]李青阳,任毅,王建红,等.急性间歇性卟啉病与糖代谢[J].国际内分泌代谢杂志,2021,41(05):426-429.[doi:10.3760/cma.j.cn121383-20200515-05039]
　Li Qingyang,Ren Yi,Wang Jianhong,et al.Acute intermittent porphyria and glucose metabolism[J].International Journal of Endocrinology and Metabolism,2021,41(05):426-429.[doi:10.3760/cma.j.cn121383-20200515-05039]
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急性间歇性卟啉病与糖代谢()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
41
期数:
2021年05期
页码:
426-429
栏目:
“特殊类型糖尿病”专题
出版日期:
2021-09-30

文章信息/Info

Title:
Acute intermittent porphyria and glucose metabolism
作者:
李青阳1; 任毅2; 王建红3; 杨静2
1山西医科大学第一临床医学院,太原 030001; 2山西医科大学第一医院内分泌科,太原 030001; 3山西医科大学附属心血管病医院神经内科,太原 030024
Author(s):
Li Qingyang1;  Ren Yi2;  Wang Jianhong3;  Yang Jing2.
1The First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China; 2Department of Endocrinology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China; 3Department of Neurology, Cardiovascular Hospital Affiliated to Shanxi Medical University, Taiyuan 030024, China
关键词:
急性间歇性卟啉病;  卟啉病;  糖尿病;  特殊类型糖尿病
Keywords:
Acute intermittent porphyria;  Porphyria;  Diabetes mellitus;  Specific type of diabetes
DOI:
10.3760/cma.j.cn121383-20200515-05039
摘要:
急性间歇性卟啉病(AIP)临床表现复杂多样,可累及全身多个系统。部分卟啉病患者可伴发有糖尿病,故卟啉病一直被列为特殊类型糖尿病之中。AIP可能通过血红素缺乏、过氧化物酶体增殖物激活受体-γ共激活物-1α(PGC-1α)的表达增强、炎性作用、抵抗素的升高、线粒体损伤等多方面机制影响血糖水平。糖代谢也可对卟啉代谢产生影响。禁食可导致AIP的急性发作,而2型糖尿病的发病和高糖饮食对卟啉病有一定的“保护作用”。葡萄糖在急性肝卟啉病发作时的有益作用可能得益于胰岛素水平的升高。机体是一个有机的整体,卟啉代谢与糖代谢之间存在着联系,但仍需要进一步关注和明确。
Abstract:
Acute intermittent porphyria(AIP)has complex and diverse clinical manifestations, of ten involves multiple systems. Some patients with porphyria may be accompanied by diabetes, so porphyria has always been listed as a special type of diabetes. AIP may affect the level of blood glucose through heme deficiency, enhanced expression of peroxisome proliferator-activated receptor γ coactivator-1α(PGC-1α), inflammation, increased resistin, mitochondrial dysfunction and other mechanisms. Glucose metabolism also affects porphyrin metabolism. Fasting can lead to acute attacks of AIP; the onset of type 2 diabetes and a high carbohydrate diet have a "protective effect" on porphyria. The beneficial effect of glucose on AIP may be due to increased insulin levels. The body is an organic whole, and there is a association between porphyrin metabolism and glucose metabolism, but it still needs further attention and clarification.

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备注/Memo

备注/Memo:
基金项目:山西省重点研发计划项目(201903D321127); 山西省卫生计划生育委员会课题(2017043)
通信作者:杨静,Email: yangjlm@126.com
更新日期/Last Update: 2021-10-10