[1]罗凯明 蒋晓红 华飞.糖尿病对肿瘤发生的影响及机制[J].国际内分泌代谢杂志,2020,40(02):125-128,133.[doi:10.3760/cma.j.issn.1673-4157.2020.02.013]
　Luo Kaiming,Jiang Xiaohong,Hua Fei.Effects and mechanisms of diabetes on tumorigenesis[J].International Journal of Endocrinology and Metabolism,2020,40(02):125-128,133.[doi:10.3760/cma.j.issn.1673-4157.2020.02.013]
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糖尿病对肿瘤发生的影响及机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
40
期数:
2020年02期
页码:
125-128,133
栏目:
基础研究
出版日期:
2020-03-20

文章信息/Info

Title:
Effects and mechanisms of diabetes on tumorigenesis
作者:
罗凯明 蒋晓红 华飞
苏州大学附属第三医院(常州市第一人民医院)内分泌科 213000
Author(s):
Luo Kaiming;  Jiang Xiaohong;  Hua Fei
Department of Endocrinology, The Third Affiliated Hospital of Suchow University, Changzhou 213000, China
关键词:
糖尿病;  肿瘤;  发病机制
Keywords:
Diabetes Mellitus;  Neoplasms;  Pathogenesis
DOI:
10.3760/cma.j.issn.1673-4157.2020.02.013
摘要:
糖尿病与恶性肿瘤均为常见病,发病率与死亡率逐年增加。研究显示,糖尿病与肿瘤两者之间存在独立相关性。近年来研究发现,糖尿病可显著升高胰腺癌、肝癌、结肠癌、乳腺癌和前列腺癌的患病风险。机制研究显示,葡萄糖通过c-Jun氨基末端激酶、表皮生长因子/表皮生长因子受体、磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白等信号通路,调节肿瘤细胞周期,促进肿瘤细胞增殖、迁移和侵袭能力,进而促进肿瘤的发生和发展。
Abstract:
Diabetes and malignant tumors are common diseases, the morbidity and mortality increase year by year. Studies of diabetes and cancer have shown an independent correlation between them. In recent years, studies have shown that diabetes significantly increased the risk of pancreatic, liver, colon, breast and prostate cancers. Studies on molecular mechanisms have shown that glucose regulates tumor cell cycle and promotes tumor cell proliferation, migration and invasion through c-Jun N-terminal kinase, epidermal growth factor receptor/epidermal growth factor receptor, phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin and other signaling pathways, then promotes the development and progression of tumor.

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备注/Memo

备注/Memo:
通信作者:华飞,Email:huafei1970@suda.edu.cn
基金项目:常州市卫健委重大科技项目(ZD201512,ZD201903); 江苏省妇幼健康科研项目(F201803)
Corresponding author: Hua Fei, Email: huafei1970@suda.edu.cn
Fund program:Major Science and Technology Projects of Changzhou Health Commision(ZD201512, ZD201903); Maternal and Child Health Research Project of Jiangsu Province(F201803)
更新日期/Last Update: 2020-03-20