[1]张贺 杨立英 黄雯莉 王文昭 陈素凤 任路平.长链非编码RNA与非酒精性脂肪性肝病[J].国际内分泌代谢杂志,2020,40(04):241-243248.[doi:10.3760/cma.j.issn.1673-4157.2020.04.006]
　Zhang He,Yang Liying,Huang Wenli,et al.Long non-coding RNA and non-alcoholic fatty liver disease[J].International Journal of Endocrinology and Metabolism,2020,40(04):241-243248.[doi:10.3760/cma.j.issn.1673-4157.2020.04.006]
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长链非编码RNA与非酒精性脂肪性肝病
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
40
期数:
2020年04期
页码:
241-243248
栏目:
综述
出版日期:
2020-07-20

文章信息/Info

Title:
Long non-coding RNA and non-alcoholic fatty liver disease
作者:
张贺1; 2 杨立英1; 2 黄雯莉1; 2 王文昭1; 2 陈素凤1; 2 任路平1; 2
1河北医科大学,石家庄 050017; 2河北省人民医院内分泌代谢病一区,石家庄 050051
Author(s):
Zhang He1; 2;  Yang Liying1; 2;  Huang Wenli1; 2;  Wang Wenzhao1; 2;  Chen Sufeng1; 2;  Ren Luping1; 2
1Hebei Medical University, Shijiazhuang 050017, China; 2Endocrine and Metabolic Disease Area 1, Hebei General Hospital, Shijiazhuang 050051, China
关键词:
非酒精性脂肪性肝病;  长链非编码RNA;  甘油三酯脂肪酶;  类固醇受体RNA激活剂
Keywords:
Non-alcoholic fatty liver;  Long non-coding RNA;  Fatty triglyceride lipase;  Steroid receptor RNA activator
DOI:
10.3760/cma.j.issn.1673-4157.2020.04.006
摘要:
LncRNA是由200多个核苷酸组成的转录产物,缺乏蛋白质编码能力。近年来lncRNAs已成为多种生物过程的重要调控因子,广泛参与了许多生物学过程,包括细胞分化、肿瘤发生、免疫反应、肝脏脂代谢和其他生物学过程。LncRNA可以调控多种基因表达,影响肝细胞内脂代谢,进而参与非酒精性脂肪性肝病的发生、发展,包括通过影响肝脏脂质合成、脂肪酸β氧化、通过microRNA调节某些靶点以及对肝脏基因的表观遗传调控来发挥作用。
Abstract:
LncRNA is a transcription product consisting of more than 200 nucleotides, which lacks the ability to encode proteins. In recent years, lncRNAs have become important regulators of various biological processes, and have been widely involved in many biological processes, including stem cell pluripotency, embryogenesis, cell differentiation, liver lipid metabolism and other biological processes. LncRNA can regulate the expression of a variety of genes and affect lipid metabolism in liver cells, and then participate in the development of non-alcoholic fatty liver disease. These include effects on liver lipid synthesis, fatty acid beta oxidation, regulation of certain targets by microRNA, and epigenetic regulation of liver genes.

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备注/Memo

备注/Memo:
通信作者:任路平,Email:renluping1122@163.com
Corresponding author: Ren Luping, Email:renluping1122@163.com
更新日期/Last Update: 2020-07-20