[1]杨佳苗 沈山梅.水通道蛋白7与脂肪组织代谢的关系[J].国际内分泌代谢杂志,2019,39(04):253-256.[doi:10.3760/cma.j.issn.1673-4157.2019.04.009]
　Yang Jiamiao,Shen Shanmei.Association between aquaporin 7 and adipose metabolism[J].International Journal of Endocrinology and Metabolism,2019,39(04):253-256.[doi:10.3760/cma.j.issn.1673-4157.2019.04.009]
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水通道蛋白7与脂肪组织代谢的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年04期
页码:
253-256
栏目:
综述
出版日期:
2019-07-20

文章信息/Info

Title:
Association between aquaporin 7 and adipose metabolism
作者:
杨佳苗 沈山梅
南京大学医学院附属鼓楼医院内分泌科 210008
Author(s):
Yang Jiamiao;  Shen Shanmei
Department of Endocrinology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China
关键词:
水通道蛋白;  肥胖;  脂肪组织
Keywords:
Aquaporin;  Obesity;  Adipose tissue
DOI:
10.3760/cma.j.issn.1673-4157.2019.04.009
摘要:
水通道蛋白7(AQP7)是一种参与甘油跨膜运输的孔状膜转运蛋白。研究证明,在脂肪组织中存在AQP7的广泛分布。AQP7介导脂肪细胞释放甘油的过程,并且组织AQP7基因的表达以及细胞膜表面AQP7蛋白的表达水平,均受到多种代谢相关激素如胰岛素、瘦素等的调控。除此以外,现已证实多种代谢疾病如糖尿病等伴随脂肪组织AQP7表达水平的变化。
Abstract:
Aquaporin 7(AQP7)is a kind of pore-forming transmembrane protein that facilitates the transport of glycerol across membranes. It has been proved that AQP7 expressed in adipose tissue and took part in the efflux of glycerol from adipocytes. The expression of AQP7 in adipose tissue is regulated by hormones associated with metabolism, such as insulin and leptin. Furthermore, changes in the expression of AQP7 has been observed in several metabolic diseases like diabetes and so on.

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备注/Memo

备注/Memo:
通信作者:沈山梅,Email:shanmeishen@126.com
Corresponding author: Shen Shanmei, Email: shanmeishen@126.com
基金项目:江苏省医学重点学科资助项目(XK201105); 江苏省中医药局科技项目(YB2015072)
Fund program:Key Disciplines Funding of Medicine of Jiangsu Province of China(XK201105); Science and Technology Project of Traditional Chinese of Jiangsu Province(YB2015072)
更新日期/Last Update: 2019-11-29