[1]张玉洁 孟召伟 章明放 宋丽丽 李宁.甲状腺疾病的代谢组学研究现状[J].国际内分泌代谢杂志,2019,39(03):173-177.[doi:10.3760/cma.j.issn.1673-4157.2019.03.007]
 Zhang Yujie,Meng Zhaowei,Zhang Mingfang,et al.Research status of metabolomics in thyroid diseases[J].International Journal of Endocrinology and Metabolism,2019,39(03):173-177.[doi:10.3760/cma.j.issn.1673-4157.2019.03.007]
点击复制

甲状腺疾病的代谢组学研究现状()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年03期
页码:
173-177
栏目:
综述
出版日期:
2019-05-20

文章信息/Info

Title:
Research status of metabolomics in thyroid diseases
作者:
张玉洁1 孟召伟2 章明放3 宋丽丽4 李宁2
1天津医科大学总医院病理科 300052; 2天津医科大学总医院核医学科 300052; 3天津市第一中心医院病理科 300192; 4天津中医药大学中药学院 300193
Author(s):
Zhang Yujie1 Meng Zhaowei2 Zhang Mingfang3 Song Lili4 Li Ning2
1Department of Pathology, the General Hospital, Tianjin Medical University, Tianjin 300052, China; 2Department of Unclear Medicine, the General Hospital, Tianjin Medical University, Tianjin 300052, China; 3Department of Pathology, Tianjin First Central Hospital, Tianjin 300192, China; 4College of Traditional Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 300193, China
关键词:
代谢组学 甲状腺癌 甲状腺功能异常 桥本甲状腺炎
Keywords:
Metabolomics Thyroid cancer Thyroid dysfunction Hashimoto's thyroiditis
DOI:
10.3760/cma.j.issn.1673-4157.2019.03.007
摘要:
代谢组学作为继基因组学、转录组学、蛋白组学之后的又一新兴学科,是系统生物学的一个重要部分。代谢组学是对生物体在病理生理刺激下产生的代谢产物的动态分析,反映了生物系统整体功能或状态的最终结果。运用代谢组学的方法对甲状腺疾病的不同样本进行代谢物的变化分析,并结合相关基因和蛋白质的研究方法,对揭示甲状腺疾病的发生机制、提供准确诊断依据以及有效判断预后有着至关重要的意义。
Abstract:
Metabolomics is an important component of systems biology as a new subject after genomics, transcriptomics and proteomics. Metabolomics is a dynamic analysis of the metabolites produced by organisms under pathological and physiological stimulation, which reflects the final result of the whole function or state of biological system. Using metabolomics to analyze the metabolites changes in different samples of thyroid diseases and combining the research methods for related genes and proteins, is of vital significance to reveal the mechanism, provide accurate diagnostic basis and effectively judge the prognosis.

参考文献/References:

[1] Melo M,Gaspar da Rocha A,Batista R,et al.TERT, BRAF, and NRAS in primary thyroid cancer and metastatic disease[J].J Clin Endocrinol Metab,2017,102(6):1898-1907.DOI:10.1210/jc.2016-2785.
[2] Luo D,Zhan S,Xia W,et al.Proteomics study of serum exosomes from papillary thyroid cancer patients[J].Endocr Relat Cancer,2018,25(10):879-891.DOI:10.1530/ERC-17-0547.
[3] Nicholson JK, Connelly J, Lindon JC,et al.Metabonomics: a platform for studying drug toxicity and gene function[J].Nat Rev Drug Discov,2002,1(2):153-161.DOI: 10.1038/nrd728.
[4] Deja S,Dawiskiba T,Balcerzak W,et al.Follicular adenomas exhibit a unique metabolic profile. 1H NMR studies of thyroid lesions[J].PLoS One,2013,8(12):e84637. DOI:10.1371/journal.pone.0084637.
[5] Brennan L.NMR-based metabolomics: from sample preparation to applications in nutrition research[J].Prog Nucl Magn Reson Spectrosc,2014,83:42-49.DOI:10.1016/j.pnmrs.2014.09.001.
[6] 赵祯,马宇,沈国华,等.代谢组学在甲状腺疾病中的应用 [J].中华核医学与分子影像杂志,2017,37(1):49-52.DOI:10.3760/cma.j.issn.2095-2848.2017.01.014.
[7] O'Connell TM.Recent advances in metabolomics in oncology[J].Bioanalysis,2012,4(4):431-451.DOI:10.4155/bio.11.326.
[8] Griffin JL,Walker L,Shore RF,et al.High-resolution magic angle spinning 1H-NMR spectroscopy studies on the renal biochemistry in the bank vole(Clethrionomys glareolus)and the effects of arsenic(As3+)toxicity[J].Xenobiotica,2001,31(6):377-385.DOI:10.1080/00498250110055938.
[9] Drexler DM,Reily MD,Shipkova PA.Advances in mass spectrometry applied to pharmaceutical metabolomics[J].Anal Bioanal Chem,2011,399(8):2645-2653.DOI:10.1007/s00216-010-4370-8.
[10] Zhang A,Sun H,Wang P,et al.Modern analytical techniques in metabolomics analysis[J].Analyst,2012,137(2):293-300.DOI:10.1039/c1an15605e.
[11] Fuhrer T,Zamboni N.High-throughput discovery metabolomics[J].Curr Opin Biotechnol,2015,31:73-78.DOI:10.1016/j.copbio.2014.08.006.
[12] Taylor J,King RD,Altmann T,et al.Application of metabolomics to plant genotype discrimination using statistics and machine learning[J].Bioinformatics,2002,18(Suppl 2):S241-S248.
[13] Dunn WB,Bailey NJ,Johnson HE.Measuring the metabolome: current analytical technologies[J].Analyst,2005,130(5):606-625.DOI:10.1039/b418288j.
[14] 中华医学会核医学分会.131I治疗分化型甲状腺癌指南(2014版)[J].中华核医学与分子影像杂志,2014,34(4):264-278.DOI:10.3760/cma.j.issn.2095-2848.2014.04.002.
[15] Yao Z,Yin P,Su D,et al.Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter[J].Mol Biosyst,2011,7(9):2608-2614.DOI:10.1039/c1mb05029j.
[16] 叶艳,赵树君,李永梅,等.碘摄入量对TPC-1甲状腺乳头状癌原位裸鼠模型的影响[J]. 中华内分泌代谢杂志,2014,30(7):558-561.DOI:10.3760/cma.j.issn.1000-6699.2014.07.004.
[17] Miccoli P,Torregrossa L,Shintu L,et al.Metabolomics approach to thyroid nodules: a high-resolution magic-angle spinning nuclear magnetic resonance-based study[J].Surgery,2012,152(6):1118-1124.DOI:10.1016/j.surg.2012.08.037.
[18] Shang X,Zhong X,Tian X.Metabolomics of papillary thyroid carcinoma tissues: potential biomarkers for diagnosis and promising targets for therapy[J].Tumour Biol,2016,37(8):11163-11175.DOI:10.1007/s13277-016-4996-z.
[19] Zhao WX,Wang B,Zhang LY,et al.Analysis on the metabolite composition of serum samples from patients with papillary thyroid carcinoma using nuclear magnetic resonance[J].Int J Clin Exp Med,2015,8(10):18013-18022.
[20] Li Y,Chen M,Liu C,et al.Metabolic changes associated with papillary thyroid carcinoma: a nuclear magnetic resonance-based metabolomics study[J].Int J Mol Med,2018,41(5):3006-3014.DOI:10.3892/ijmm.2018.3494.
[21] Jordan KW,Adkins CB,Cheng LL,et al.Application of magnetic-resonance-spectroscopy- based metabolomics to the fine-needle aspiration diagnosis of papillary thyroid carcinoma[J].Acta Cytol,2011,55(6):584-589.DOI:10.1159/000333271.
[22] Torregrossa L,Shintu L,Nambiath Chandran J,et al.Toward the reliable diagnosis of indeterminate thyroid lesions: a HRMAS NMR-based metabolomics case of study[J].J Proteome Res,2012,11(6):3317-3325.DOI:10.1021/pr300105e.
[23] Ryoo I,Kwon H,Kim SC,et al.Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: potential application for the preoperative diagnosis of thyroid cancer[J].Sci Rep,2016,6:30075.DOI:10.1038/srep30075.
[24] 郑雯洁,徐雅男,周秦毅,等.女性甲状腺乳头状癌代谢组学特征及其与肿瘤大小、淋巴结转移的关系[J].中华耳鼻咽喉头颈外科杂志,2016,51(2):105-111.DOI:10.3760/cma.j.issn.1673-0860.2016.02.007.
[25] Seo JW,Han K,Lee J,et al.Application of metabolomics in prediction of lymph node metastasis in papillary thyroid carcinoma[J].PLoS One,2018,13(3):e0193883. DOI:10.1371/journal.pone.0193883.
[26] Xu Y,Zheng X,Qiu Y,et al.Distinct metabolomic profiles of papillary thyroid carcinoma and benign thyroid adenoma[J].J Proteome Res,2015,14(8):3315-3321.DOI:10.1021/acs.jproteome.5b00351.
[27] 阿布都沙拉木·阿布力.甲状腺乳头状癌和结节性甲状腺肿患者血浆代谢组学研究[D].新疆医科大学, 2014.
[28] 中华医学会核医学分会.131I治疗格雷夫斯甲亢指南(2013版)[J].中华核医学与分子影像杂志,2013, 33(2):83-95. DOI:10.3760/cma.j.issn.2095-2848.
[29] Piras C,Arisci N,Poddighe S,et al.Metabolomic profile in hyperthyroid patients before and after antithyroid drug treatment: correlation with thyroid hormone and TSH concentration[J].Int J Biochem Cell Biol,2017,93:119-128.DOI:10.1016/j.biocel.2017.07.024.
[30] Chng CL,Lim AY,Tan HC,et al.Physiological and metabolic changes during the transition from hyperthyroidism to euthyroidism in Graves' disease[J].Thyroid,2016,26(10):1422-1430.DOI:10.1089/thy.2015.0602.
[31] Al-Majdoub M,Lantz M,Spégel P.Treatment of swedish patients with Graves' hyperthyroidism is associated with changes in acylcarnitine levels[J].Thyroid,2017,27(9):1109-1117.DOI:10.1089/thy.2017.0218.
[32] Wu S,Tan G,Dong X,et al.Metabolic profiling provides a system understanding of hypothyroidism in rats and its application[J].PLoS One,2013,8(2):e55599.DOI:10.1371/journal.pone.0055599.
[33] Yao X,Sa R,Ye C,et al.Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: a targeted metabolomic approach[J].Prostaglandins Other Lipid Mediat,2015,118-119:11-18.DOI:10.1016/j.prostaglandins.2015.03.005.
[34] Chen YK,Lin CL,Cheng FT,et al.Cancer risk in patients with Hashimoto's thyroiditis: a nationwide cohort study[J].Br J Cancer,2013,109(9):2496-2501.DOI:10.1038/bjc.2013.597.
[35] Zhang Y,Dai J,Wu T,et al.The study of the coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma[J].J Cancer Res Clin Oncol,2014,140(6):1021-1026.DOI:10.1007/s00432-014-1629-z.
[36] Liang J,Zeng W,Fang F,et al.Clinical analysis of Hashimoto thyroiditis coexistent with papillary thyroid cancer in 1392 patients[J].Acta Otorhinolaryngol Ital,2017,37(5):393-400.DOI:10.14639/0392-100X-1709.
[37] Marotta V,Sciammarella C,Chiofalo MG,et al.Hashimoto's thyroiditis predicts outcome in intrathyroidal papillary thyroid cancer[J].Endocr Relat Cancer,2017,24(9):485-493.DOI:10.1530/ERC-17-0085.
[38] Pagni F, De Sio G, Garancini M,et al. Proteomics in thyroid cytopathology: relevance of MALDI-imaging in distinguishing malignant from benign lesions[J].Proteomics,2016,16(11-12):1775-1784. DOI:10.1002/pmic.201500448.

相似文献/References:

[1]张蓉,俞立波,李连喜.组蛋白修饰与甲状腺癌[J].国际内分泌代谢杂志,2014,(05):348.[doi:10.3760/cma.j.issn.1673-4157.2014.05.017]
 Zhang Rong,Yu Libo,Li Lianxi..Histone modification and thyroid tumor[J].International Journal of Endocrinology and Metabolism,2014,(03):348.[doi:10.3760/cma.j.issn.1673-4157.2014.05.017]
[2]李兴佳,徐书杭,刘超.雌激素及其受体与甲状腺癌的关系[J].国际内分泌代谢杂志,2016,36(04):273.[doi:10.3760/cma.j.issn.1673-4157.2016.04.15]
 Li Xingjia,Xu Shuhang,Liu Chao.Relationship between estrogen, its receptors and thyroid cancer[J].International Journal of Endocrinology and Metabolism,2016,36(03):273.[doi:10.3760/cma.j.issn.1673-4157.2016.04.15]
[3]郑仁东,刘超.白细胞介素-6与甲状腺疾病[J].国际内分泌代谢杂志,2016,36(05):352.[doi:10.3760/cma.j.issn.1673-4157.2016.05.18]
 Zheng Rendong,Liu Chao.Interleukin-6 and thyroid disease[J].International Journal of Endocrinology and Metabolism,2016,36(03):352.[doi:10.3760/cma.j.issn.1673-4157.2016.05.18]
[4]郑仁东,刘超.STAT3与甲状腺肿瘤[J].国际内分泌代谢杂志,2017,37(05):345.
 Zheng Rendong,Liu Chao..STAT3 and thyroid tumor[J].International Journal of Endocrinology and Metabolism,2017,37(03):345.
[5]孟祥慧 徐书杭 陈国芳 刘超.二甲双胍在甲状腺癌防治中的作用[J].国际内分泌代谢杂志,2018,38(04):237.[doi:10.3760/cma.j.issn.1673-4157.2018.04.005]
 Meng Xianghui*,Xu Shuhang,Chen Guofang,et al.Role of metformin in prevention and treatment of thyroid cancer[J].International Journal of Endocrinology and Metabolism,2018,38(03):237.[doi:10.3760/cma.j.issn.1673-4157.2018.04.005]
[6]曹星月 武晓泓.基因拷贝数异常在甲状腺癌诊断和预后判断中的 应用进展[J].国际内分泌代谢杂志,2019,39(01):29.[doi:10.3760/cma.j.issn.1673-4157.2019.01.007]
 Cao Xingyue,Wu Xiaohong.Progress in the application of gene copy number variations in diagnosis and prognosis of thyroid cancer[J].International Journal of Endocrinology and Metabolism,2019,39(03):29.[doi:10.3760/cma.j.issn.1673-4157.2019.01.007]
[7]张会峰 胡天赤 陈学勤 叶向荣 刘超.丙型肝炎病毒感染与自身免疫性甲状腺疾病 及甲状腺癌风险[J].国际内分泌代谢杂志,2019,39(02):128.[doi:10.3760/cma.j.issn.1673-4157.2019.02.014]
 Zhang Huifeng,Hu Tianchi,Chen Xueqin,et al.Relationship between hepatitis C virus infection and the risk of autoimmune thyroid diseases and thyroid cancer[J].International Journal of Endocrinology and Metabolism,2019,39(03):128.[doi:10.3760/cma.j.issn.1673-4157.2019.02.014]
[8]田勍,洪天配.甲状腺结节诊治过程中的难点与应对[J].国际内分泌代谢杂志,2021,41(06):557.[doi:10.3760/cma.j.cn121383-20210727-07074]
 Tian Qing,Hong Tianpei..Difficulties and countermeasures in the diagnosis and treatment of thyroid nodules[J].International Journal of Endocrinology and Metabolism,2021,41(03):557.[doi:10.3760/cma.j.cn121383-20210727-07074]
[9]张雅,相萍萍,徐书杭,等.经皮无水乙醇注射治疗甲状腺结节:老方法的新认识[J].国际内分泌代谢杂志,2022,42(06):469.[doi:10.3760/cma.j.cn121383-20210926-09075]
 Zhang Ya,Xiang Pingping,Xu Shuhang,et al.Percutaneous ethanol ablation for thyroid nodules: new perspectives on an old paradigm[J].International Journal of Endocrinology and Metabolism,2022,42(03):469.[doi:10.3760/cma.j.cn121383-20210926-09075]

备注/Memo

备注/Memo:
通信作者:张玉洁, Email:zhangyujie316@hotmail.com
Corresponding author: Zhang Yujie, Email:zhangyujie316@hotmail.com
更新日期/Last Update: 2019-05-20