[1]张丽 李强.微小核糖核酸调控胆固醇稳态的研究进展[J].国际内分泌代谢杂志,2018,38(05):329-332.[doi:10.3760/cma.j.issn.1673-4157.2018.05.011]
　Zhang Li,Li Qiang.Recent progress of microRNAs regulating cholesterol homeostasis[J].International Journal of Endocrinology and Metabolism,2018,38(05):329-332.[doi:10.3760/cma.j.issn.1673-4157.2018.05.011]
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微小核糖核酸调控胆固醇稳态的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年05期
页码:
329-332
栏目:
基础研究
出版日期:
2018-09-20

文章信息/Info

Title:
Recent progress of microRNAs regulating cholesterol homeostasis
作者:
张丽 李强
作者单位:150081 哈尔滨医科大学附属第二医院内分泌代谢病科
Author(s):
Zhang Li;  Li Qiang
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China
关键词:
胆固醇;  microRNA;  固醇调节元件结合蛋白;  ATP结合盒转运体A1
Keywords:
Cholesterol;  microRNA;  Sterol regulatory element-binding protein;  ATP-binding cassette A1
DOI:
10.3760/cma.j.issn.1673-4157.2018.05.011
摘要:
胆固醇稳态受多种因素的密切调节,而胆固醇代谢紊乱与2型糖尿病、动脉粥样硬化、非酒精性脂肪性肝病等多种疾病的发生、发展密切相关。微小RNA(microRNA,miRNA)是脂代谢的转录后调控因子,miRNA-185-5p、miRNA-758-5p、miRNA-33a、miRNA-21、miRNA-122和miRNA-370与胆固醇的合成有关,miRNA-33、miRNA-144、miRNA-26、miRNA-758-3p、miRNA-106b、miRNA-10b、miRNA-302、miRNA-145、miRNA-27a/b和miRNA-613与胆固醇的转运有关,多种microRNA共同参与调控胆固醇代谢中关键蛋白的表达,调控胆固醇的稳态平衡。
Abstract:
Cholesterol homeostasis is tightly regulated by a series of factors, and perturbations in cholesterol metabolism are associated with diseases such as type 2 diabetes, atherosclerosis and non-alcoholic fatty liver disease. microRNAs(miRNAs)are identified to be potent post-transcriptional regulators of lipid metabolism. miRNA-185-5p,miRNA-758-5p,miRNA-33a,miRNA-21,miRNA-122 and miRNA-370 have been shown to play important roles in regulating cholesterol synthesis, and miRNA-33, miRNA-144, miRNA-26, miRNA-758-3p, miRNA-106b, miRNA-10b, miRNA-302, miRNA-145, miRNA-27a/b and miRNA-613 have close relationships with cholesterol transport. microRNAs cooperate to regulate cholesterol homeostasis by regulating the expression of critical proteins in cholesterol metabolism.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81170744,813709027)
Fund program:National Natural Science Foundation of China(81170744, 813709027)
Fund program:Jiangsu Students' Innovation and Entrepreneurship Training Program(201613981012X); Science and Technology Project of Jian
更新日期/Last Update: 2018-09-30