[1]李耀辉,侯沃霖,刘芳.肥胖与脂肪组织慢性炎性反应[J].国际内分泌代谢杂志,2016,36(05):342-345.[doi:10.3760/cma.j.issn.1673-4157.2016.05.15]
 Li Yaohui,Hou Wolin,Liu Fang.Obesity and chronic inflammation in adipose tissue[J].International Journal of Endocrinology and Metabolism,2016,36(05):342-345.[doi:10.3760/cma.j.issn.1673-4157.2016.05.15]
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肥胖与脂肪组织慢性炎性反应()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年05期
页码:
342-345
栏目:
综述
出版日期:
2016-09-20

文章信息/Info

Title:
Obesity and chronic inflammation in adipose tissue
作者:
李耀辉侯沃霖刘芳
200233 上海交通大学附属第六人民医院内分泌代谢科,上海市糖尿病临床医学中心,上海市糖尿病研 究所,上海市糖尿病重点实验室
Author(s):
Li Yaohui Hou Wolin Liu Fang
Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Clinical Center of Diabetes, Shanghai Institute for Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai 200233,China
关键词:
脂肪组织 慢性炎症 肥胖
Keywords:
Adipose tissue Chronic inflammation Obesity
DOI:
10.3760/cma.j.issn.1673-4157.2016.05.15
摘要:
肥胖已成为世界范围内流行性疾病,可导致糖尿病、非酒精性脂肪性肝病及冠心病等相关疾病发生 率大大提高。肥胖状态下,脂肪细胞肥大、缺氧状态、内质网应激及脂毒性等会导致脂肪细胞因子功能失调,血 管通透性增加,促进免疫细胞浸润到脂肪组织中,释放更多的炎性因子,形成炎性反应的恶性循环,导致慢性炎性 状态的持续存在。
Abstract:
Obesity is becoming a prevalent disease in the world, leading to a dramatic increasion of its related disorders including diabetes mellitus, non-alcoholic fatty liver disease as well as cardiovascular disease.The adipocyte hypertrophy, hypoxia, endoplasmic reticulum stress and lipotoxicity are involved in the dysregulation of adipocytokines and increase of vessel permeability. These factors further facilitate immune cells infiltration to adipose tissues and inflammatory cytokines release.All pathophysiological changes above establish a vicious circle of chronic inflammation in fat tissue, leading to persistent chronic inflammatory state.

参考文献/References:

[1] World Health Organization. Obesity and overweight: fact sheet N°311[EB/OL]. http://www.who.int/mediacentre/factsheets/fs311/en/2015.3.7.
[2] Ng M, Fleming T, Robinson M,et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013[J].Lancet,2014,384(9945):766-781.DOI: 10.1016/S0140-6736(14)60460-8.
[3] Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor- alpha: direct role in obesity-linked insulin resistance[J].Science,1993,259(5091):87-91.
[4] Wang Y, Huang F. N-3 polyunsaturated fatty acids and inflammation in obesity: local effect and systemic benefit[J]. Biomed Res Int,2015,2015:581469. DOI: 10.1155/2015/581469.
[5] Cao H. Adipocytokines in obesity and metabolic disease[J].J Endocrinol,2014,220(2):T47-T59. DOI: 10.1530/JOE-13-0339.
[6] Baker RG, Hayden MS, Ghosh S. NF-κB, inflammation, and metabolic disease[J].Cell Metab,2011,13(1):11-22. DOI: 10.1016/j.cmet.2010.12.008.
[7] Wang XA, Zhang R, She ZG,et al. Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance[J].Hepatology,2014,59(3):870- 885. DOI: 10.1002/hep.26751.
[8] Maury E, Noël L, Detry R,et al. In vitro hyperresponsiveness to tumor necrosis factor-alpha contributes to adipokine dysregulation in omental adipocytes of obese subjects[J].J Clin Endocrinol Metab,2009,94(4):1393-1400.DOI:10.1210/jc.2008-2196.
[9] Pendyala S, Neff LM, Suárez-Fariñas M,et al. Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis[J].Am J Clin Nutr,2011,93 (2):234-242. DOI: 10.3945/ajcn.110.002683.
[10] Trussardi Fayh AP, Lopes AL, Fernandes PR, et al. Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomised clinical trial[J].Br J Nutr,2013,110(3):486-492. DOI: 10.1017/S0007114512005442.
[11] Gower BA, Goss AM. A lower-carbohydrate, higher-fat diet reduces abdominal and intermuscular fat and increases insulin sensitivity in adults at risk of type 2 diabetes[J].J Nutr, 2015, 145(1):177S-183S. DOI: 10.3945/jn.114.195065.
[12] Johnson GL, Nakamura K. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease[J].Biochim Biophys Acta,2007,1773(8):1341-1348.
[13] Han MS, Jung DY, Morel C,et al. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation[J].Science,2013,339(6116):218-222. DOI:10.1126/science.1227568.
[14] Khan S, Wang CH. ER stress in adipocytes and insulin resistance: mechanisms and significance(Review)[J].Mol Med Rep,2014,10(5):2234-2240.DOI:10.3892/mmr.2014.2532.
[15] Dong H, Huang H, Yun X,et al. Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation [J].Endocrinology,2014,155(3):818-828.DOI: 10.1210/en.2013-1667.
[16] Nishimura S, Manabe I, Nagasaki M,et al. In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue[J].J Clin Invest,2008,118(2):710-721. DOI: 10.1172/JCI33328.
[17] Piya MK, Harte AL, McTernan PG. Metabolic endotoxaemia: is it more than just a gut feeling [J].Curr Opin Lipidol,2013,24(1):78-85. DOI: 10.1097/MOL.0b013e32835b4431.
[18] Leuwer M, Welters I, Marx G,et al. Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of mice[J].Pflugers Arch,2009,457(4):731- 741.DOI: 10.1007/s00424-008-0564-8.
[19] Ridaura VK, Faith JJ, Rey FE,et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice[J].Science,2013,341(6150):1241214.DOI: 10.1126/science.1241214.
[20] Nguyen MT, Favelyukis S, Nguyen AK,et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways[J].J Biol Chem,2007,282(48):35279-35292.
[21] Akash MS, Shen Q, Rehman K,et al. Interleukin-1 receptor antagonist: a new therapy for type 2 diabetes mellitus[J]. J Pharm Sci,2012,101(5):1647-1658. DOI: 10.1002/jps.23057.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81270397); 上海市科委医学和农业领域科技支撑项目(西医重 点,15411953100)
更新日期/Last Update: 2016-11-20