[1]陈恺情,卜瑞芳.Irisin——可否让代谢性疾病治疗进入新时代[J].国际内分泌代谢杂志,2016,36(01):38-41,51.[doi:10.3760/cma.j.issn.1673-4157.2016.01.009]
 Chen Kaiqing,Bu Ruifang..Could irisin lead the treatment of metabolic diseases into a new era?[J].International Journal of Endocrinology and Metabolism,2016,36(01):38-41,51.[doi:10.3760/cma.j.issn.1673-4157.2016.01.009]
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Irisin——可否让代谢性疾病治疗进入新时代()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年01期
页码:
38-41,51
栏目:
综述
出版日期:
2016-01-20

文章信息/Info

Title:
Could irisin lead the treatment of metabolic diseases into a new era?
作者:
陈恺情卜瑞芳
214023 无锡,南京医科大学附属无锡人民医院内分泌科
Author(s):
Chen Kaiqing Bu Ruifang.
Department of Endocrinology, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi 214023, China
关键词:
Irisin 代谢性疾病 白色脂肪组织棕色化
Keywords:
Irisin Metabolic disease Browning of white adipose tissue
DOI:
10.3760/cma.j.issn.1673-4157.2016.01.009
摘要:
由Boström等于2012年初发现的肌肉因子irisin主要由运动诱导生成,能够促进白色脂肪组织棕色化,改善糖脂代谢,增加能量消耗、降低体脂量,改善胰岛素敏感性。鉴于肥胖、2型糖尿病患者irisin水平明显降低,增加irisin水平可能会预防代谢性疾病的发生。通过运动增加内源性irisin或外源性irisin替代来诱导皮下脂肪棕色化,可能起到防治肥胖、抗胰岛素抵抗等作用。但目前研究止步于动物的体内实验,在irisin成为代谢性疾病治疗的新靶点之前,仍需要大量深入细致的基础研究。
Abstract:
The myokine irisin identified by Boström at the beginning of 2012, induced by exercise mainly, can drive the browning of white adipose tissue, improve glucose and lipid metabolism,promote total body energy expenditure, reduce body fat and relieve insulin resistance. Considering the significantly reduced level of irisin in patients with obesity and type 2 diabetes mellitus, an increase in expression of irisin may be able to prevent metabolic diseases. The browning of subcutaneous fat induced by elevated endogenous irisin from exercise or recombinant exogenous substitution would contribute to the treatment and/or prevention of obesity and the effect of anti-insulin-resistance. However, the latest relative researches haven't broken the limitation to animal experiments in vivo yet. Before irisin becomes a new therapeutic target for metabolic disorders, more large-sample detailed researches are required.

参考文献/References:

[1] Boström P, Wu J, Jedrychowski MP,et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat andthermogenesis[J].Nature, 2012,481(7382):463-468. DOI: 10.1038/nature10777.
[2] Moreno-Navarrete JM, Ortega F, Serrano M,et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity andinsulin resistance[J]. J Clin Endocrinol Metab,2013,98(4):E769-E778. DOI: 10.1210/jc.2012-2749.
[3] Huh JY, Panagiotou G, Mougios V,et al.FNDC5 and irisin in humans:Ⅰ. Predictors of circulating concentrations in serum and plasma and Ⅱ. mRNA expression and circulating concentrations in response to weight loss and exercise[J].Metabolism, 2012,61(12):1725-1738. DOI: 10.1016/j.metabol.2012.09.002.
[4] Xu J, Lloyd DJ, Hale C, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure,and improvesinsulin sensitivity in diet-induced obese mice[J].Diabetes, 2009,58(1):250-259. DOI: 10.2337/db08-0392.
[5] Li D, Zhang Y, Xu L, et al. Regulation of gene expression by FSP27 in white and brown adipose tissue[J]. BMC Genomics,2010,11:446.DOI: 10.1186/1471-2164-11-446.
[6] Shan T, Liang X, Bi P,et al.Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5pathway in muscle[J].FASEB J, 2013,27(5):1981-1989.DOI: 10.1096/fj.12-225755. Epub 2013 Jan 29.
[7] He C, Bassik MC, Moresi V,et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis[J]. Nature,2012,481(7382):511-515.DOI:10.1038/nature10758.
[8] Fisher FM, Kleiner S, Douris N,et al.FGF21 regulates PGC-1α and browning of white adipose tissuesin adaptive thermogenesis[J]. Genes Dev, 2012,26(3):271-281.DOI:10.1101/gad.177857.111.
[9] Zhang HJ, Zhang XF, Ma ZM,et al.Irisin is inversely associated with intrahepatic triglyceride contents in obese adults[J]. J Hepatol,2013,59(3):557-562. DOI: 10.1016/j.jhep.2013.04.030.
[10] Wang C, Guan Y, Yang J.Cytokines in the progression of pancreatic β-cell dysfunction[J]. Int J Endocrinol, 2010,2010:515136. DOI: 10.1155/2010/515136.
[11] Wenz T, Rossi SG, Rotundo RL,et al. Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging[J]. Proc Natl Acad Sci U S A, 2009,106(48):20405-20410. DOI: 10.1073/pnas.0911570106.
[12] Sharp LZ, Shinoda K, Ohno H,et al. Human BAT possesses molecular signatures that resemble beige/brite cells[J]. PLoS One, 2012,7(11):e49452. DOI: 10.1371/journal.pone.0049452.
[13] Feldmann HM, Golozoubova V, Cannon B,et al.UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermalstress by living at thermoneutrality[J]. Cell Metab, 2009,9(2):203-209. DOI: 10.1016/j.cmet.2008.12.014.
[14] Stengel A, Hofmann T, Goebel-Stengel M,et al. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlationwith body mass index[J]. Peptides, 2013,39:125-130. DOI: 10.1016/j.peptides.2012.11.014.
[15] Choi YK, Kim MK, Bae KH, et al. Serum irisin levels in new-onset type 2 diabetes[J].Diabetes Res Clin Pract, 2013,100(1):96-101. DOI: 10.1016/j.diabres.2013.01.007.
[16] 潘玲玲,张惠杰,陈政,等.血清irisin水平与腹型肥胖成人体脂率相关[J].中华糖尿病杂志,2013,5(8):472-476.DOI: 10.3760/cma.j.issn.1674-5809.2013.08.005.
[17] Sharma N, Castorena CM, Cartee GD.Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines[J]. Nutr Metab(Lond), 2012,9(1):90. DOI: 10.1186/1743-7075-9-90.
[18] Hernández-Alvarez MI, Thabit H, Burns N,et al.Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity[J]. Diabetes Care, 2010,33(3):645-651. DOI: 10.2337/dc09-1305.
[19] Timmons JA, Baar K, Davidsen PK,et al.Is irisin a human exercise gene?[J].Nature, 2012,488(7413):E9-E10; discussion E10-1. DOI: 10.1038/nature11364.
[20] Raschke S, Elsen M, Gassenhuber H,et al. Evidence against a beneficial effect of irisin in humans[J]. PLoS One, 2013,8(9):e73680. DOI: 10.1371/journal.pone.0073680.

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更新日期/Last Update: 2016-01-20