[1]李潍 陈晓铭 武革.长链非编码RNA在甲状腺乳头状癌中的作用[J].国际内分泌代谢杂志,2015,(06):413-416.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.014]
 Li Wei,Chen Xiaoming,Wu Ge.Roles of long non-coding RNA in papillary thyroid carcinoma[J].International Journal of Endocrinology and Metabolism,2015,(06):413-416.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.014]
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长链非编码RNA在甲状腺乳头状癌中的作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年06期
页码:
413-416
栏目:
基础研究
出版日期:
2015-11-20

文章信息/Info

Title:
Roles of long non-coding RNA in papillary thyroid carcinoma
作者:
李潍 陈晓铭 武革
524001 湛江,广东医学院附属医院内分泌科
Author(s):
Li WeiChen XiaomingWu Ge
Department of Endocrinology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China
关键词:
长链非编码RNA 基因表达 甲状腺乳头状癌
Keywords:
Long non-coding RNA Gene expression Papillary thyroid carcinoma
DOI:
DOI:10.3760/cma.j.issn.1673-4157.2015.06.014
摘要:
长链非编码RNA(lncRNA)是一类转录本长度大于200 nt的RNA,自身缺乏编码蛋白质的能力,能在表观遗传学、转录水平和转录后水平调控基因表达。近年来结合微阵列芯片和基因多态性研究发现了一些lncRNA如BANCR及PTCSC3等在甲状腺乳头状癌中异常表达,调控肿瘤细胞增殖、凋亡、侵蚀及迁移等。深入研究lncRNA的作用机制将会为甲状腺肿瘤的诊治提供新的思路。
Abstract:
Long non-coding RNAs(lncRNAs)are RNAs exceeding 200 nt in lengths of transcripts,which lack the capacity for protein coding. LncRNAs regulate the expression of genes at epigenetic,transcriptional and post-transcriptional levels. In recent years, studies combining microarrays and gene polymorphism have found that a variety of lncRNAs such as BANCR,PTCSC3,etc are expressed abnormally in papillary thyroid carcinoma, and regulate the proliferation, apoptosis,migration and invasion of cancer cells. Studying the mechanism of lncRNAs will provide new ideas for the diagnosis and treatment of thyroid cancer.

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备注/Memo

备注/Memo:
基金项目:湛江市财政资金科技专项竞争性分配项目(2013A304) 作者单位:524001 湛江,广东医学院附属医院内分泌科 通信作者:武革,Email:wuge427@aliyun.com
更新日期/Last Update: 2015-11-20