[1]吴开泽 林文锋 方淑斌 张振.阿仑膦酸钠与特立帕肽不同联合方案治疗骨质疏松[J].国际内分泌代谢杂志,2015,(05):340-343.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.013]
 Wu Kaize*,Lin Wenfeng,Fang Shubin,et al.Different combination of alendronate and teriparatide in the treatment of osteoporosis[J].International Journal of Endocrinology and Metabolism,2015,(05):340-343.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.013]
点击复制

阿仑膦酸钠与特立帕肽不同联合方案治疗骨质疏松()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年05期
页码:
340-343
栏目:
临床研究
出版日期:
2015-09-20

文章信息/Info

Title:
Different combination of alendronate and teriparatide in the treatment of osteoporosis
作者:
吴开泽 林文锋 方淑斌 张振
510282 广州,南方医科大学第二临床医学院(吴开泽,林文锋,方淑斌); 510280 广州,南方医科大学珠江医院内分泌科(张振)
Author(s):
Wu Kaize*Lin WenfengFang ShubinZhang Zhen.
*The Second Clinical Medical College of Southern Medical University, Guangzhou 510282,China
关键词:
阿仑膦酸钠 特立帕肽 骨质疏松
Keywords:
Alendronate Teriparatide Osteoporosis
DOI:
DOI:10.3760/cma.j.issn.1673-4157.2015.05.013
摘要:
阿仑膦酸钠与特立帕肽同步应用,可增加骨密度,但疗效比特立帕肽单独治疗低。阿仑膦酸钠与特立帕肽序贯治疗,在增加骨密度的同时还能够促进骨组织微损伤修复和提高骨矿物质分布的均一性; 阿仑膦酸钠与特立帕肽间断疗法,如在特立帕肽单药治疗基础上联合阿仑膦酸钠、然后停止特立帕肽并继续应用阿仑膦酸钠,可增加骨密度。不同联合方案对骨质疏松均有一定的疗效而作用不尽相同,为骨质疏松的临床治疗提供了理论依据。
Abstract:
Using alendronate and teriparatide simultaneously can increase bone mass density(BMD), but the effect was lower than that in teriparatide used alone. Using alendronate and terinaration in sequence can increase BMD,as well as bone microstructure and the homogeneous distribution of mineral substance. Using alendronate and teriparatide intermittently, such as using teriparatide for a while, and then combined with alendronate followed by alendronate treatment only, can increase BMD. Therefore, different combinations have positive but different effects on osteoporosis, which are helpful in providing the theoretical basis for osteoporosis treatment.

参考文献/References:

[1] Zarowitz BJ,Cheng LI,Allen C,et al. Osteoporosis prevalence and characteristics of treated and untreated nursing home residents with osteoporosis[J]. J Am Med Dir Assoc, 2015,16(4):341-348. [/br][2] Hassler N, Gamsjaeger S, Hofstetter B, et al. Effects of long-term alendronate treatment on postmenopausal osteoporosis bone material properties[J]. Osteoporos Int, 2015,26(1):339-352. [/br][3] Niimi R, Kono T, Nishihara A, et al. Analysis of daily teriparatide treatment for osteoporosis in men[J]. Osteoporos Int, 2015,26(4):1303-1309. [/br][4] Finkelstein JS, Hayes A, Hunzelman JL, et al. The effects of parathyroid hormone, alendronate, or both in men with osteoporosis[J]. N Engl J Med, 2003,349(13):1216-1226. [/br][5] Finkelstein JS, Wyland JJ, Lee H, et al. Effects of teriparatide, alendronate, or both in women with postmenopausal osteoporosis[J]. J Clin Endocrinol Metab, 2010,95(4):1838-1845. [/br][6] Muschitz C, Kocijan R, Fahrleitner-Pammer A, et al. Antiresorptives overlapping ongoing teriparatide treatment result in additional increases in bone mineral density[J]. J Bone Miner Res, 2013,28(1):196-205. [/br][7] Cosman F, Nieves J, Woelfert L, et al. Alendronate does not block the anabolic effect of PTH in postmenopausal osteoporotic women[J]. J Bone Miner Res, 1998,13(6):1051-1055. [/br][8] Finkelstein JS, Leder BZ, Burnett SM, et al. Effects of teriparatide, alendronate, or both on bone turnover in osteoporotic men[J]. J Clin Endocrinol Metab, 2006,91(8):2882-2887. [/br][9] Minne H, Audran M, Simões ME, et al. Bone density after teriparatide in patients with or without prior antiresorptive treatment: one-year results from the EUROFORS study[J]. Curr Med Res Opin, 2008,24(11):3117-3128. [/br][10] Obermayer-Pietsch BM, Marin F, McCloskey EV, et al. Effects of two years of daily teriparatide treatment on BMD in postmenopausal women with severe osteoporosis with and without prior antiresorptive treatment[J]. J Bone Miner Res, 2008,23(10):1591-1600. [/br][11] Hofstetter B, Gamsjaeger S, Varga F, et al. Bone quality of the newest bone formed after two years of teriparatide therapy in patients who were previously treatment-naive or on long-term alendronate therapy[J]. Osteoporos Int, 2014,25(12):2709-2719. [/br][12] Cosman F, Wermers RA, Recknor C, et al. Effects of teriparatide in postmenopausal women with osteoporosis on prior alendronate or raloxifene: differences between stopping and continuing the antiresorptive agent[J]. J Clin Endocrinol Metab, 2009,94(10):3772-3780. [/br][13] Cosman F, Keaveny TM, Kopperdahl D, et al. Hip and spine strength effects of adding versus switching to teriparatide in postmenopausal women with osteoporosis treated with prior alendronate or raloxifene[J]. J Bone Miner Res, 2013,28(6):1328-1336. [/br][14] Boonen S, Marin F, Obermayer-Pietsch B, et al. Effects of previous antiresorptive therapy on the bone mineral density response to two years of teriparatide treatment in postmenopausal women with osteoporosis[J]. J Clin Endocrinol Metab, 2008,93(3):852-860. [/br][15] Whitmarsh T, Treece GM, Gee AH, et al. Mapping bone changes at the proximal femoral cortex of postmenopausal women in response to alendronate and teriparatide alone, combined or sequentially[J]. J Bone Miner Res, 2015,30(7):1309-1318. [/br][16] Ma YL, Zeng QQ, Chiang AY, et al. Effects of teriparatide on cortical histomorphometric variables in postmenopausal women with or without prior alendronate treatment[J]. Bone, 2014,59:139-147. [/br][17] Keel C, Kraenzlin ME, Kraenzlin CA, et al. Impact of bisphosphonate wash-out prior to teriparatide therapy in clinical practice[J]. J Bone Miner Metab, 2010,28(1):68-76. [/br][18] Stepan JJ, Burr DB, Li J, et al. Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis[J]. Osteoporos Int, 2010,21(12):2027-2036. [/br][19] Krause M, Soltau M, Zimmermann EA, et al. Effects of long-term alendronate treatment on bone mineralisation, resorption parameters and biomechanics of single human vertebral trabeculae[J]. Eur Cell Mater, 2014,28:152-163; discussion 163-165. [/br][20] Dobnig H, Stepan JJ, Burr DB, et al. Teriparatide reduces bone microdamage accumulation in postmenopausal women previously treated with alendronate[J]. J Bone Miner Res, 2009,24(12):1998-2006. [/br][21] Misof BM, Paschalis EP, Blouin S, et al. Effects of 1 year of daily teriparatide treatment on iliacal bone mineralization density distribution(BMDD)in postmenopausal osteoporotic women previously treated with alendronate or risedronate[J]. J Bone Miner Res, 2010,25(11):2297-2303. [/br][22] Gamsjaeger S, Buchinger B, Zoehrer R, et al. Effects of one year daily teriparatide treatment on trabecular bone material properties in postmenopausal osteoporotic women previously treated with alendronate or risedronate[J]. Bone, 2011,49(6):1160-1165. [/br][23] Andrews EB, Gilsenan AW, Midkiff K, et al. The US postmarketing surveillance study of adult osteosarcoma and teriparatide: study design and findings from the first 7 years[J]. J Bone Miner Res, 2012,27(12):2429-2437. [/br][24] Cosman F, Nieves JW, Zion M, et al. Retreatment with teriparatide one year after the first teriparatide course in patients on continued long-term alendronate[J]. J Bone Miner Res, 2009,24(6):1110-1115. [/br][25] Finkelstein JS, Wyland JJ, Leder BZ, et al. Effects of teriparatide retreatment in osteoporotic men and women[J]. J Clin Endocrinol Metab, 2009,94(7):2495-2501. [/br][26] Cosman F, Nieves JW, Zion M, et al. Daily or cyclical teriparatide treatment in women with osteoporosis on no prior therapy and women on alendronate[J]. J Clin Endocrinol Metab, 2015,100(7):2769-2776. [/br][27] Muschitz C, Kocijan R, Fahrleitner-Pammer A, et al. Overlapping and continued alendronate or raloxifene administration in patients on teriparatide: effects on areal and volumetric bone mineral density-the CONFORS Study[J]. J Bone Miner Res, 2014,29(8):1777-1785.

备注/Memo

备注/Memo:
作者单位:510282 广州,南方医科大学第二临床医学院(吴开泽,林文锋,方淑斌); 510280 广州,南方医科大学珠江医院内分泌科(张振) 通信作者:张振,Email:zzhen311@163.com
更新日期/Last Update: 2015-09-20