[1]曹书义,袁莉.胰腺上皮细胞可能成为胰岛β细胞再生的新来源[J].国际内分泌代谢杂志,2015,(02):114-116.[doi:10.3760/cma.j.issn.1673-4157.2015.02.011]
　Cao Shuyi,Yuan Li..Pancreatic epithelium may be a new source of islet β cells regeneration[J].International Journal of Endocrinology and Metabolism,2015,(02):114-116.[doi:10.3760/cma.j.issn.1673-4157.2015.02.011]
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胰腺上皮细胞可能成为胰岛β细胞再生的新来源()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年02
页码:
114-116
栏目:
综述
出版日期:
2015-03-20

文章信息/Info

Title:
Pancreatic epithelium may be a new source of islet β cells regeneration
作者:
曹书义; 袁莉
430022　武汉，华中科技大学同济医学院附属协和医院内分泌科
Author(s):
Cao Shuyi; Yuan Li.
Department of Endocrinology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China Corresponding author：Yuan Li，Email：yuanli18cn@yahoo.com.cn
关键词:
糖尿病; 胰腺上皮细胞; 胰岛β细胞; 再生
Keywords:
Diabetes mellitus; Pancreatic epithelial cells; Islet β cells; Regeneration
DOI:
10.3760/cma.j.issn.1673-4157.2015.02.011
摘要:
促进β细胞再生，维持功能性β细胞的数量，是治疗糖尿病的根本。胰腺上皮细胞包括β细胞、导管细胞、腺泡细胞及α细胞。研究表明，与多能干细胞相比，这些成体细胞具有更明显的优势，可能通过不同途径重新生成β细胞从而实现β细胞的再生。已分化的β细胞可以被诱导增殖或者退回至祖细胞状态重新分化为β细胞。而在胰腺受损、代谢应激、基因操作等条件下，其他胰腺上皮细胞可能直接转分化为β细胞或者成为内分泌兼性祖细胞再分化为β细胞。
Abstract:
Promoting β cells regeneration and increasing the number of functional β cells is crucial to treat diabetes. Pancreatic epithelial cells include β cell，duct cell acinar cell，and α cell. Compared with pluripotent stem cells，the adult cells have a clear advantage to realize the regeneration of β cells through different pathways. The differentiated β cells can be induced to proliferation or lost to dedifferentiation.Then the dedifferentiated cells may redifferentiate to β cells. Under specific conditions such as damaged pancreas，metabolic stress，genetic operation，other cells in pancreatic epithelium also exhibit the plasticity to go directly to β cells or become endocrine facultative progenitor cells to reprogramme into β cells.

参考文献/References:

[1]　Avrahami D，Kaestner KH.Epigenetic regulation of pancreas development and function[J].Semin Cell Dev Biol，2012，23（6）：693-700. 　
[2]　Gregg BE，Moore PC，Demozay D，et al.Formation of a human beta-cell population within pancreatic islets is set early in life[J].J Clin Endocrinol Metab，2012，97（9）：3197-3206. 　
[3]　Caballero F，Siniakowicz K，Hollister-Lock J，et al.Birth and death of human beta-cells in pancreases from cadaver donors，autopsies，surgical specimens，and islets transplanted into mice[J].Cell Transplant，2014，23（2）：139-151. 　
[4]　Gargani S，Thevenet J，Yuan JE，et al.Adaptive changes of human islets to an obesogenic environment in the mouse[J].Diabetologia， 2013，56（2）：350-358. 　
[5]　Levitt HE，Cyphert TJ，Pascoe JL，et al.Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency（SCID）mice[J]. Diabetologia，2011，54（3）：572-582. 　
[6]　Porat S，Weinberg-Corem N，Tornovsky-Babaey S，et al.Control of pancreatic beta cell regeneration by glucose metabolism[J].Cell Metab，2011，13（4）：440-449. 　
[7]　Stolovich-Rain M，Hija A，Grimsby J，et al.Pancreatic beta cells in very old mice retain capacity for compensatory proliferation[J]. J Biol Chem，2012，287（33）：27407-27414. 　
[8]　Criscimanna A，Speicher JA，Houshmand G，et al.Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice[J].Gastroenterology，2011，141（4）：1451-1462，1462.e1-6. 　
[9]　Yoneda S，Uno S，Iwahashi H，et al.Predominance of beta-cell neogenesis rather than replication in humans with an impaired glucose tolerance and newly diagnosed diabetes[J]. J Clin Endocrinol Metab， 2013，98（5）：2053-2061.
[10]　Rankin MM，Wilbur CJ，Rak K，et al.beta-Cells are not generated in pancreatic duct ligation-induced injury in adult mice[J].Diabetes， 2013，62（5）：1634-1645.
[11]　Pan FC，Bankaitis ED，Boyer D，et al.Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration[J].Development， 2013，140（4）：751-764.
[12]　Yu L，Luo JX，Wei JL，et al.Insulin-producing acinar cells in adult human pancreas[J].Pancreas，2014，43（4）：592-596.
[13]　Baeyens L，Lemper M，Leuckx G，et al.Transient cytokine treat-ment induces acinar cell reprogramming and regenerates func-tional beta cell mass in diabetic mice[J].Nat Biotechnol， 2014，32（1）：76-83.
[14]　Bramswig NC，Everett LJ，Schug J，et al.Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming[J]. J Clin Invest，2013，123（3）：1275-1284.
[15]　Yang YP，Thorel F，Boyer DF，et al.Context-specific alpha- to-beta-cell reprogramming by forced Pdx1 expression[J].Genes Dev，2011，25（16）：1680-1685.
[16]　Al-Hasani K，Pfeifer A，Courtney M，et al.Adult duct-lining cells can reprogram into beta-like cells able to counter repeated cycles of toxin-induced diabetes[J].Dev Cell， 2013，26（1）：86-100.
[17]　Thorel F，Nepote V，Avril I，et al.Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss[J].Nature， 2010，464（7292）：1149-1154.
[18]　Saisho Y，Manesso E，Butler AE，et al.Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes[J].Diabetes，2011，60（3）：848-856.
[19]　Talchai C，Xuan S，Lin HV，et al.Pancreatic beta cell dediffer-entiation as a mechanism of diabetic beta cell failure[J].Cell， 2012，150（6）：1223-1234.
[20]　White MG，Marshall HL，Rigby R，et al.Expression of mes-enchymal and ?琢-cell phenotypic markers in islet β-cells in recently diagnosed diabetes[J]. Diabetes Care，2013，36（11）：3818-3820.
[21]　Fiori JL，Shin YK，Kim W，et al.Resveratrol prevents beta-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet[J]. Diabetes，2013，62（10）：3500-3513.
[22]　Weir GC，Aguayo-Mazzucato C，Bonner-Weir S.beta-cell dedif-ferentiation in diabetes is important， but what is it?[J].Islets，2013，5（5）：233-237.
[23]　Wang Z，York NW，Nichols CG，et al.Pancreatic beta cell dedif-ferentiation in diabetes and redifferentiation following insulin therapy[J].Cell Metab，2014，19（5）：872-882.

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备注/Memo

备注/Memo:
通信作者：袁莉，Email: yuanli18cn@yahoo.com.cn
更新日期/Last Update: 2015-03-20