参考文献/References:
[1] Reaven GM.Relationships among insulin resistance，type 2 diabetes，essential hypertension，and cardiovascular disease：similarities and differences[J].J Clin Hypertens （Greenwich），2011，13（4）：238-243.
[2] Weiss MA.Proinsulin and the genetics of diabetes mellitus[J]. J Boil Chem，2009，284（29）：19159-19163.
[3] Gidalevitz T，Prahlad V，Morimoto RI.The stress of protein misfolding：from single cells to multicellular organisms[J].Cold Spring Harb Perspect Biol，2011，3（6）：a009704.
[4] Wang J，Chen Y，Yuan X，et al.Control of precursor maturation and disposal is an early regulative mechanism in the normal insulin production of pancreatic β-cells[J].PLoS One，2011，6（4）：e19446.
[5] Mahler HC，Friess W，Grauschopf U，et al.Protein aggregation：pathways，induction factors and analysis[J].J Pharm Sci，2009，
98（9）：2909-2934.
[6] Liu M，Li YL，Cavener D，et al.Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum[J].J BiolChem，2005，280（14）：13209-13212.
[7] Zhang XP，Yuan QX，Tang W，et al.Substrate-favored lysosomal and proteasomal pathways participate in the normal balance control of insulin precursor maturation and disposal in beta-cells[J].PLoS One，2011，6（11）：e27647.
[8] Eizirik DL，Miani M，Cardozo AK.Signalling danger：endoplasmic reticulum stress and the unfolded proteinresponse in pancreatic islet inflammation[J].Diabetologia，2013，56（2）：234-241.
[9] Zhang BY，Liu M，Arvan P.Behavior in the eukaryotic secretory pathway of insulin-containing fusion proteins and single-chain insulins bearing various B-chain mutations[J].J Boil Chem，2003，
278（6）： 3687-3693.
[10] Liu M，Li Y，Cavener D，et al.Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum[J].J Biol Chem，2005，280（14）：13209-13212.
[11] Liu M，Ramos-Castaneda J，Arvan P.Role of the connecting peptide in insulin biosynthesis[J].J Boil Chem，2003，278（17）：14798-14805.
[12] Basu R，Oudit GY，Wang XH，et al.Type 1 diabetic cardiomy-opathy in the Akita （Ins2（WT/C96Y）） mouse model is charac-terized by lipotoxicity and diastolic dysfunction with preserved systolic function[J].Am J Physiol Heart Circ Physiol，2009，297（6）：H2096-H2108.
[13] Yuan QX，Tang W，Zhang XP，et al.Proinsulin atypical maturation and disposal induces extensive defects in mouse Ins2（+/akita） beta-cells[J].PLoS One，2012，7（4）：e35098.
[14] Rajan S，Eames SC，Park SY，et al.In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes[J].Am J Physiol Endocrinol Metab，2010，298（3）：E403-E410.
[15] Oyadomari S，Koizumi A，Takeda K，et al.Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes[J].J Clin Invest，2002，109（4）：525-532.
[16] Sou SN，Ilieva KM，Polizzi KM.Binding of human BiP to the ER stress transducers IRE1 and PERK requires ATP[J].Biochem Biophys Res Commun，2012，420（2）：473-478.
[17] Laybutt R，Preston A，Akerfeldt M，et al.Endoplasmic reticulum stress contributes to beta-cell apoptosis in type 2 diabetes[J].Diabetologia，2006，55（1）：A58．
[18] Liu M，Hodish I，Rhodes CJ，et al.Proinsulin maturation，misfolding，and proteo-toxicity[J].Proc Nat Acad Sci U S A，2007，104（40）：15841-15846.
[19] Babaya N，Nakayama M，Moriyama H，et al.A new model of insulin-deficient diabetes：male NOD mice with a single copy of Ins1 and no Ins2[J].Diabetologia，2006，49（6）：1222-1228.
[20] Leroux L.Compensatory responses in mice carrying a null mutation for Ins1 or Ins2[J].Diabetes，2001，50（90001）：S150-S153.
[21] Araki E，Oyadomari S，Mori M.Impact of endoplasmic reticulum stress pathway on pancreatic beta-cells and diabetes mellitus[J].Exp Biol Med （May-wood），2003，228（10）：1213-1217.
[22] Mori K.Tripartite management of unfolded protein in the endoplasmic reticulum[J].Cell，2000，101（5）：451-454.
[23] Harding HP，Zhang YH，Bertolotti A，et al.Perk is essential for translational regulation and cell survival during the unfolded protein response[J].Mol Cell，2000，5（5）：897-904.
[24] Bertolotti A，Zhang YH，Hendershot LM，et al.Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response[J].Nat Cell Biol，2000，2（6）：326-332.
[25] Biden TJ，Boslem E，Chu KY，et al.Lipotoxic endoplasmic reticulum stress，beta cell failure，and type 2 diabetes mellitus[J].Trends Endocrinol Metab，2014，25（8）：389-398.
[26] Teodoro-Morrison T，Schuiki I，Zhang L，et al.GRP78 overpro-duction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice[J].Diabetologia，2013，56（5）：1057-1067.
[27] Yamagishi N，Ueda T，Mori A，et al.Decreased expression of endoplasmic reticulum chaperone GRP78 in liver of diabetic mice[J].Biochem Biophys Res Commun，2012，417（1）：364-370.
[28] Ladiges WC，Knoblaugh SE，Morton JF，et al.Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58（IPK）[J].Diabetes，2005，54（4）：1074-1081.
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