[1]玄先法,李清芹,王玉新,等.肾炎康复片联合缬沙坦治疗Ⅳ期糖尿病肾病蛋白尿的临床研究[J].国际内分泌代谢杂志,2014,(05):353-355.[doi:10.3760/cma.j.issn.1673-4157.2014.05.019]
　Xuan Xianfa,Li Qingqin,Wang Yuxin,et al.Clinical study of Shenyankangfu tablet combined with valsartan capsule on proteinuria in patients with stage Ⅳ diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2014,(05):353-355.[doi:10.3760/cma.j.issn.1673-4157.2014.05.019]
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肾炎康复片联合缬沙坦治疗Ⅳ期糖尿病肾病蛋白尿的临床研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年05期
页码:
353-355
栏目:
短篇论著
出版日期:
2014-10-31

文章信息/Info

Title:
Clinical study of Shenyankangfu tablet combined with valsartan capsule on proteinuria in patients with stage Ⅳ diabetic nephropathy
作者:
玄先法; 李清芹; 王玉新; 张以勤; 朱璇; 叶婧; 吕天羽; 颜建华; 郑亚丽; 武挺
361021 厦门市第二医院肾内科,中心实验室(李清芹)
Author(s):
Xuan Xianfa; Li Qingqin; Wang Yuxin; Zhang Yiqin; Zhu Xuan; Ye Jing; Lyu Tianyu; Yan Jianhua; Zheng Yali; Wu Ting.
Department of Nephrology,The Second Hospital of Xiamen,Xiamen361021,China Corresponding author: Wang Yuxin, Email: wyx1000@126.com
关键词:
肾炎康复片;  缬沙坦;  糖尿病肾病
Keywords:
ShenyanKangfu tablet;  Valsartan capsule;  Diabetic nephropathy
DOI:
10.3760/cma.j.issn.1673-4157.2014.05.019
摘要:
目的 探讨肾炎康复片联合缬沙坦治疗肾功能正常Ⅳ期糖尿病肾病患者蛋白尿的临床疗效。方法 将厦门市第二医院2009年—2012年就诊的120例肾功能正常Ⅳ期糖尿病肾病患者,随机数字表法分为单纯缬沙坦组、肾炎康复片联合缬沙坦组,两组患者各60例,均常规予以限制饮食,控制血糖、血压,调节血脂等基础治疗; 此外,单纯缬沙坦组予以缬沙坦160 mg/次、每天1次,肾炎康复片联合缬沙坦组予以肾炎康复片5片/次、每天3次,联合缬沙坦160 mg/次、每天1次,治疗16周后,检测两组患者的24 h尿白蛋白定量、血肌酐、血糖、血脂等水平。结果 治疗16周后肾炎康复片联合缬沙坦组临床疗效总有效率66.7%,高于单纯缬沙坦组(46.7%),差异有统计学意义(P<0.05)。治疗后两组患者24 h尿白蛋白定量均较治疗前明显下降,肾炎康复片联合缬沙坦组尿白蛋白定量明显低于单纯缬沙坦组,差异有统计学意义[(1.77±0.79)g vs.(2.29±1.36)g,t=2.617,P<0.05]。两组患者血肌酐、血糖等指标与治疗前相比差异无统计学意义(P均>0. 05)。结论 肾炎康复片联合缬沙坦治疗比单用缬沙坦更能有效降低肾功能正常Ⅳ期糖尿病肾病患者的蛋白尿。
Abstract:
Objective To investigate the therapeutic effects of Shenyankangfu tablet combined with valsartan capsule on proteinuria in patients with stage Ⅳ diabetic nephropathy and normal renal function. Methods 120 patients with stage Ⅳ diabetic nephropathy and normal renal function were randomly divided into two groups:valsartan group(n=60,valsartan 160 mg qd)and valsartan combined with Shenyankangfu tablets group(n=60, Shenyankangfu tablet 5 tablets tid combined with Valsartan 160 mg qd), and were treated for 16 weeks. Both groups were treated with the same basic diet control and routine treatment. After 16-week course of treatment, 24 hours urinary protein, serum creatinine, blood glucose and blood lipids were determined and compared. Results After 16-week treatment, the total efficiency of the experiment group and the control group was 66.7% and 46.7% respectively, there was a significant difference between the two groups(P<0.05). The 24 hours urinary protein of both groups after treatment were significantly decreased,but in valsartan combined with Shenyankangfu tablets group, the 24 hours urinary protein decreased greatly [(1.77±0.79)g vs.(2.29±1.36)g,t=2.617,P<0.05]. The levels of serum creatinine and blood glucose of both groups had no significant differences before and after treatment(P>0.05).Conclusion Shenyankangfu tablet combined with Valsartan capsule can decrease the urinary protein in patients with stage Ⅳ diabetic nephropathy,the therapeutic effect is better than valsartan alone.

参考文献/References:

[1] 赵毓芳,史国辉,孙原,等. 肾炎康复片治疗老年糖尿病肾病的临床观察[J]. 中国老年学杂志, 2012,32(16):3435-3436.
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[4] Kuriyama S,Tomonari H,Tokudome G,et al.Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria,retinopathy and strokes[J].Kidney Int,2002,61:1086-1097.
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备注/Memo

备注/Memo:
通信作者:王玉新,Email:wyx1000@126.com
更新日期/Last Update: 2014-09-20